A5065235825- Multiple Sclerosis Research Studies
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Polyomavirus and related diseases
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Cannabis and Cannabinoid Research
- Cerebral Palsy and Movement Disorders
- Nerve injury and regeneration
- Epilepsy research and treatment
- Autoimmune and Inflammatory Disorders Research
- Neurological disorders and treatments
- Olfactory and Sensory Function Studies
- Cardiac tumors and thrombi
- Toxin Mechanisms and Immunotoxins
- Immunotherapy and Immune Responses
- Trigeminal Neuralgia and Treatments
- T-cell and Retrovirus Studies
- Psychosomatic Disorders and Their Treatments
- Vestibular and auditory disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Tryptophan and brain disorders
- Nicotinic Acetylcholine Receptors Study
- Parkinson's Disease and Spinal Disorders
Centro Neurolesi Bonino Pulejo
2016-2025
University of Messina
1998-2020
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2020
Weatherford College
2020
Creative Commons
2020
Committee on Publication Ethics
2018-2019
Almirall (Spain)
2017
Southampton General Hospital
1995
Fatebenefratelli Hospital
1994
<h3>Background</h3> The approval of 9-δ-tetrahydocannabinol and cannabidiol (THC:CBD) oromucosal spray (Sativex) for the management treatment-resistant multiple sclerosis (MS) spasticity opened a new opportunity many patients. aim our study was to describe Sativex effectiveness adverse events profile in large population Italian patients with MS daily practice setting. <h3>Methods</h3> We collected data all starting between January 2014 February 2015 from mandatory medicines agency (AIFA)...
Objective . The aim of our study was to better investigate the role Sativex ® in improving pain multiple sclerosis (MS) patients by means either clinical or neurophysiological assessment.
To examine retrospectively the effects of plasmapheresis (PLEX) on survival and clinical outcomes patients with multiple sclerosis (MS) natalizumab (NTZ)-associated progressive multifocal leukoencephalopathy (PML).The medical literature was searched for terms leukoencephalopathy. A total 193 international 34 Italian NTZ-PML cases were included. Clinical outcome determined by comparing patients' status at PML diagnosis after resolution. The PLEX, sex, age, country, pre-PML Expanded Disability...
Background The approval of Sativex for the management multiple sclerosis (MS) spasticity opened a new opportunity to many patients. In Italy, healthcare payer can be fully reimbursed by involved pharma company with cost treatment patients not responding after 4 week (28 days) trial period (Payment Results, PbR), and 50% 6 weeks (42 other discontinuing (Cost Sharing, CS). aim our study was describe discontinuation profile from large population treated Italian MS Methods We collected data 30...
Motor impairment is the most common symptom in multiple sclerosis (MS). Thus, a variety of new rehabilitative strategies, including robotic gait training, have been implemented, showing their effectiveness. The aim our study was to investigate whether an intensive preceding traditional treatment, could be useful improving and potentiating motor performance MS patients. Forty-five patients, who fulfilled inclusion criteria, were enrolled this randomized into either control group (CG) or...
Objective . To investigate the influence of demographic and clinical variables, such as depression, fatigue, quantitative MRI marker on cognitive performances in a sample patients affected by multiple sclerosis (MS). Methods 60 MS (52 relapsing remitting 8 primary progressive) underwent neuropsychological assessments using Rao’s Brief Repeatable Battery Neuropsychological Tests (BRB-N), Beck Depression Inventory-second edition (BDI-II), Fatigue Severity Scale (FSS). We performed magnetic...
Sativex is an emergent treatment option for spasticity in patients affected by multiple sclerosis (MS). This oromucosal spray, acting as a partial agonist at cannabinoid receptors, may modulate the balance between excitatory and inhibitory neurotransmitters, leading to muscle relaxation that turn responsible improvement. Nevertheless, since clinical assessment not be sensitive enough detect changes, other more objective tools should tested better define real drug effect. The aim of our study...
Abstract Background: Multiple sclerosis (MS) is a demyelinating disease, affecting both the sensorimotor and cognitive systems. The typical pattern of impairment includes reduced speed information processing, decreased phonological semantic speech fluency, deficits in verbal visual episodic memory, as well attention executive dysfunctions. We aimed to investigate influence neurologic music therapy (NMT) on mood, motivation, emotion status, functions patients with MS. Methods: Thirty MS were...
Abstract Multiple sclerosis (MS) is a chronic demyelinating autoimmune disorder affecting the central nervous system and targets myelin sheaths around nerves. Local problem: Medical advances have enabled patients to lead better quality of life (QoL) than before. However, because its chronicity unpredictability, it remains very challenging disease for both their families, as involves continued use medication slow down progression. The aim this study assess drug adherence in with MS. In...
Spasticity is a disabling symptom of MS that enhanced during interferon beta-1b (IFNβ-1b) treatment. Nineteen patients with primary progressive were treated IFNβ-1b; an additional 19 did not receive this Thirteen the IFNβ-1b had increased spasticity requiring antispasticity drug administration. This observation suggests further studies are needed before interferons can be so widely used in patients.
The purpose of this study is to assess the efficacy and tolerability a new vision-based non-intrusive eye tracker in population composed normal controls patients affected by nonadvanced Parkinson's disease (PD). PD characteristically have difficulty sustaining repetitive motor actions. Previous studies showed progressive bradykinesia hypokinesia pursuit ocular movements (POM) advanced PD. We found that values POM were lower than (p < 0.001). In patients, correlated closely with Hoehn Yahr...
In the present study, we used TNF-alpha receptor 1 knockout (TNF-alphaR1KO) mice to evaluate a possible role of on pathogenesis ischemia and reperfusion injury multivisceral organs. Ischemia was induced in by clamping superior mesenteric artery celiac for 30 min, followed thereafter reperfusion. Sixty minutes after reperfusion, animals were killed histological examination biochemical studies. Injured wild-type (WT) developed significant increase ileum levels, myeloperoxidase activity, marked...
Multiple sclerosis (MS) is a chronic inflammatory disease and one of the leading causes disability in young adults. Functional markers able to predict MS progression are still lacking. It recognized that olfactory dysfunction may be an early symptom MS. The aim this study was investigate whether alterations event-related potentials could play prognostic role Thirty patients affected by relapsing-remitting underwent potential examination (T0). Three years after baseline (T1), 28 30 were...
Multiple sclerosis is a progressive degenerative disorder that frequently involves the development of physical and emotional changes, including loss limb function or sensitivity, sexual dysfunction, cognitive mood alterations. It likely these alterations lead to changes in body aspects. However, knowledge about image perception multiple lacking. The present study investigated relationship between its correlation with disability, neuropsychiatric symptoms, self-esteem. A total 100 outpatients...