A5072229617- Transcranial Magnetic Stimulation Studies
- Hearing Loss and Rehabilitation
- Noise Effects and Management
- Neurological disorders and treatments
- Vehicle Noise and Vibration Control
- Motor Control and Adaptation
- Muscle activation and electromyography studies
- Vestibular and auditory disorders
- Acoustic Wave Phenomena Research
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Speech and Audio Processing
- Structural Health Monitoring Techniques
- Neuroscience and Music Perception
- EEG and Brain-Computer Interfaces
- Genetic Neurodegenerative Diseases
- Neuroscience and Neural Engineering
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Multisensory perception and integration
- Neural dynamics and brain function
- Image and Signal Denoising Methods
Sorbonne Université
2013-2024
Centre National de la Recherche Scientifique
2013-2024
Inserm
2013-2024
Institut du Cerveau
2012-2024
Pitié-Salpêtrière Hospital
2002-2024
Laboratoire de Mécanique et d’Acoustique
2014-2024
Centrale Marseille
2012-2024
Assistance Publique – Hôpitaux de Paris
2011-2024
National Institute of Neurological Disorders and Stroke
2005-2024
National Institutes of Health
2005-2024
1. Two independent methods were used, in man, to assess changes presynaptic inhibition of I a terminals at the onset selective voluntary contractions: (1) measurement amount heteronymous monosynaptic facilitation (from quadriceps muscle soleus motoneurones) provide an assessment ongoing exerted on fibres responsible for facilitation; (2) H reflexes 40‐60 ms after short vibration tibialis anterior tendon estimate excitability interneurones mediating from afferents test reflex (soleus or...
1. A method to assess changes in presynaptic inhibition of I a afferent terminals man is proposed. The soleus H reflex was facilitated by heteronymous volley from quadriceps and the amount facilitation used estimate size conditioning excitatory post-synaptic potential (e.p.s.p.). It argued that this e.p.s.p. as measured resulting reflects on corresponding fibres. decrease may then be ascribed an increase fibres mediating volley. 2. That caused purely monosynaptic prerequisite for validity...
Abstract Dystonia has a wide clinical spectrum from early‐onset generalized to late‐onset sporadic, task‐specific forms. The genetic origin of the former been clearly established. A critical role repetitive skilled motor tasks put forward for latter, while underlying vulnerability traits are still being searched for. Using magnetoencephalography, we looked structural abnormalities reflecting preexisting dysfunction. We studied finger representations both hands in primary sensory cortex, as...
Journal Article CHANGES IN PRESYNAPTIC INHIBITION OF Ia FIBRES MAN WHILE STANDING Get access R. KATZ, KATZ Search for other works by this author on: Oxford Academic PubMed Google Scholar S. MEUNIER, MEUNIER E. PIERROT-DESEILLIGNY Correspondence to: Professor Emmanuel Pierrot-Deseilligny, Clinical Neurophysiology, Department of Reedu cation, Hôpital de Salpêtriêre, 47 Bd I'Hôpital, 75651 Paris cedex 13, France Brain, Volume 111, Issue 2, April 1988, Pages 417–437,...
Structural abnormalities were detected in bilateral primary sensorimotor areas writer's cramp. Evidence other dystonia, including blepharospasm and cervical suggest that structural may be observed brain such as the cerebellum cramp.To test hypothesis are present along cerebellar circuits patients with cramp.Using voxel-based morphometry, authors compared structure of 30 right-handed cramp healthy control subjects matched for gender, age, handedness.Gray matter decrease was found hand area...
1. The time course of the changes in presynaptic inhibition Ia fibres to soleus motoneurones has been investigated during a voluntary ramp‐and‐hold plantar flexion. 2. Monosynaptic facilitation H reflex was evoked by stimulation inferior (homonymous) and femoral (heteronymous) nerves. Changes mediating conditioning volleys were inferred from amount such constant stimulations. 3. At beginning contraction, both homonymous heteronymous facilitations markedly increased with respect their rest...
Introduction: Chronic unimanual motor practice increases the output not only in trained but also nonexercised homologous muscle opposite limb. We examined hypothesis that adaptations cortical excitability of nontrained primary cortex (iM1) and interhemispheric inhibition from to M1 mediate this interlimb cross education. Methods: Healthy, young volunteers (n = 12) performed 1000 submaximal voluntary contractions (MVC) right first dorsal interosseus (FDI) at 80% MVC during 20 sessions....
Plasticity of the human primary motor cortex (M1) has a critical role in control and learning. The cerebellum facilitates these functions using sensory feedback. We investigated whether cerebellar processing afferent information influences plasticity (M1). Theta-burst stimulation protocols (TBS), both excitatory inhibitory, were used to modulate excitability posterior condition an ongoing M1 plasticity. was subsequently induced 2 different ways: by paired associative (PAS) involving TBS that...
See Raethjen and Muthuraman (doi:10.1093/brain/awv238) for a scientific commentary on this article. Essential tremor is movement disorder characterized by during voluntary movements, mainly affecting the upper limbs. The cerebellum its connections to cortex are known be involved in essential tremor, but no task-free intrinsic signatures of related structural cerebellar defects have so far been found cortical motor network. Here we used voxel-based morphometry, tractography resting-state...
The possibility was investigated that interneuronal pathways contribute to Ia excitation of quadriceps motoneurones in normal man. Two techniques were used: the indirect spatial facilitation technique for investigating summation excitatory effects interneurones which may be interposed motoneurones; post‐stimulus time histogram method course measurement firing probability voluntarily activated motor units following femoral nerve stimulation. applied while using H reflex assess excitability...
1. Ia projections and recurrent inhibition from quadriceps to tibialis anterior soleus motoneurones were investigated in man. 2. Changes the firing probability of individual voluntarily activated motor units studied following electrical stimulation femoral nerve or tendon tap. 3. Femoral evoked an early increase units. This excitation was also by a tap, had low threshold its central delay estimated be same as that homonymous monosynaptic excitation. These findings strongly suggest...
A large body of evidence points to a role basal ganglia dysfunction in the pathophysiology dystonia, but recent studies indicate that cerebellar may also be involved. The cerebellum influences sensorimotor adaptation by modulating plasticity primary motor cortex. Motor cortex is maladaptive patients with writer's cramp. Here we examined whether putative dystonia linked these patients' plasticity. To end compared performances and healthy control subjects reaching task involving visuomotor...
DCC is the receptor for netrin, a protein that guides axon migration of developing neurons across body's midline. Mutations in gene were recently identified 2 families with congenital mirror movements (MM). The objective was to study clinical and genetic characteristics 3 European MM test whether this disorder genetically homogeneous.We studied total 13 affected subjects. Each patient had standardized interview neurologic examination, focusing on phenomenology course MM. severity also...
Plasticity of primary motor cortex is severely impaired in Parkinson's disease and chronic dopaminergic treatment reported not to rescue it. The effect an acute dose levodopa on cortical plasticity so far variable. In this study, it was hypothesized that would be restored as a long duration response stable responders while those with complications have reduction or loss similar the decay signs. Patients were carefully stratified based their into (n = 17), fluctuating non-dyskinetics 18)...
The plasticity of primary motor cortex (M1) in patients with Parkinson's disease (PD) and levodopa-induced dyskinesias (LIDs) is severely impaired. We recently reported young healthy subjects that inhibitory cerebellar stimulation enhanced the sensorimotor M1 was induced by paired associative (PAS). This study demonstrates deficient 16 LIDs could be reinstated a single session real but not sham stimulation. evident only when sensory component involved induction plasticity, indicating...