A5019253327- Neurological disorders and treatments
- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Epilepsy research and treatment
- Motor Control and Adaptation
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Muscle activation and electromyography studies
- Vagus Nerve Stimulation Research
- Sleep and Wakefulness Research
- Systemic Lupus Erythematosus Research
- Botulinum Toxin and Related Neurological Disorders
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Ultrasound and Hyperthermia Applications
- Neural and Behavioral Psychology Studies
- Migraine and Headache Studies
University Medical Center of the Johannes Gutenberg University Mainz
2016-2025
Johannes Gutenberg University Mainz
2016-2025
Saarland University
2024-2025
Klinik und Poliklinik für Neurologie
2006-2025
University College London
2020-2024
University Hospital and Clinics
2024
University Medical Center
2024
University of Oxford
2024
Nicolae Testemițanu State University of Medicine and Pharmacy
2018-2022
Heinrich Heine University Düsseldorf
2022
Background: Monitoring neuronal injury remains one key challenge in early relapsing-remitting multiple sclerosis (RRMS) patients. Upon axonal damage, neurofilament – a major component of the neuro-axonal cytoskeleton is released into cerebrospinal fluid (CSF) and subsequently peripheral blood. Objective: To investigate relevance serum light chain (sNfL) for acute chronic damage RRMS. Methods: sNfL levels were determined 74 patients (63 therapy-naive) with recently diagnosed clinically...
Periodic features of neural time-series data, such as local field potentials (LFPs), are often quantified using power spectra. While the aperiodic exponent spectra is typically disregarded, it nevertheless modulated in a physiologically relevant manner and was recently hypothesised to reflect excitation/inhibition (E/I) balance neuronal populations. Here, we used cross-species vivo electrophysiological approach test E/I hypothesis context experimental idiopathic Parkinsonism. We demonstrate...
Background Deep learning (DL)–accelerated MRI can substantially reduce examination times. However, studies prospectively evaluating the diagnostic performance of DL-accelerated reconstructions in acute suspected stroke are lacking. Purpose To investigate interchangeability with conventional patients ischemic at 1.5 T. Materials and Methods In this prospective study, 211 participants underwent clinically indicated T between June 2022 March 2023. For each participant, (including T1-weighted,...
Postural tremor is the leading symptom in essential tremor, but some cases intention and limb ataxia emerge can become highly disabling features. Deep brain stimulation of thalamus or subthalamic white matter improve ataxia; however, underlying network mechanisms are enigmatic. To elucidate deep we pursued a multimodal approach combining kinematic measures reach-to-grasp movements, clinical assessments, physiological neuronal excitability probabilistic tractography from diffusion tensor...
Cerebello-thalamo-cortical loops play a major role in the emergence of pathological tremors and voluntary rhythmic movements. It is unclear whether these differ anatomically or functionally different types tremor. We compared age- sex-matched groups patients with Parkinson's disease essential tremor healthy controls (n = 34 per group). High-density 256-channel EEG multi-channel EMG from extensor flexor muscles both wrists were recorded simultaneously while extending hands against gravity...
Brain connectivity profiles seeding from deep brain stimulation (DBS) electrodes have emerged as informative tools to estimate outcome variability across DBS patients. Given the limitations of acquiring and processing patient-specific diffusion-weighted imaging data, a number studies employed normative atlases human connectome. To date, it remains unclear whether information would strengthen accuracy such analyses. Here, we compared similarities differences between patient-specific,...
Neuroinflammation is a pathophysiological hallmark of multiple sclerosis and has close mechanistic link to neurodegeneration. Although this potentially targetable, robust translatable models reliably quantify track neuroinflammation in both mice humans are lacking. The choroid plexus (ChP) plays pivotal role regulating the trafficking immune cells from brain parenchyma into cerebrospinal fluid (CSF) recently attracted attention as key structure initiation inflammatory responses. In...
Longitudinal analysis of white matter lesion changes on serial MRI has become an important parameter to study diseases with white-matter lesions. Here, we build earlier work cross-sectional segmentation; present a fully automatic pipeline for FLAIR-hyperintense Our algorithm requires three-dimensional gradient echo T1- and FLAIR- weighted images at 3 Tesla as well available segmentations both time points. Preprocessing steps include filling intrasubject registration. For segmentation...
BackgroundWe aim to evaluate serum neurofilament light chain (sNfL), indicating neuroaxonal damage, as a biomarker at diagnosis in large cohort of early multiple sclerosis (MS) patients.MethodsIn multicentre prospective longitudinal observational cohort, patients with newly diagnosed relapsing-remitting MS (RRMS) or clinically isolated syndrome (CIS) were recruited between August 2010 and November 2015 22 centers. Clinical parameters, MRI, sNfL levels (measured by single molecule array)...
To determine the prevalence of antibodies to Epstein-Barr virus (EBV) in a large cohort patients with early multiple sclerosis (MS).Serum samples were collected from 901 clinically isolated syndrome (CIS) or relapsing-remitting (RRMS) participating German National MS cohort, prospective stringent inclusion criteria. nuclear antigen (EBNA)-1 and viral capsid (VCA) measured diluted sera by chemiluminescence immunoassays (CLIAs). Sera EBNA-1 VCA antibody-negative retested undiluted an EBV IgG...
The disruption of pathologically enhanced beta oscillations is considered one the key mechanisms mediating clinical effects deep brain stimulation on motor symptoms in Parkinson's disease. However, a specific modulation other distinct physiological or pathological oscillatory activities could also play an important role symptom control and function recovery during stimulation. Finely tuned gamma have been suggested to be prokinetic nature, facilitating preferential processing neural...
We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data determined expanded in its scope has applied multiple an effort modulate neural circuitry. The was founded 2012 providing a space where clinicians, engineers, researchers from industry academia discuss current emerging technologies logistical ethical issues facing the field. emphasis is on cutting edge...
Background Obesity reportedly increases the risk for developing multiple sclerosis (MS), but little is known about its association with disability accumulation. Methods This nationwide longitudinal cohort study included 1066 individuals newly diagnosed MS from German National cohort. Expanded Disability Status Scale (EDSS) scores, relapse rates, MRI findings and choice of immunotherapy were compared at baseline years 2, 4 6 between obese (body mass index, BMI ≥30 kg/m 2 ) non-obese (BMI...
Importance For the large population of people with drug-refractory epilepsy, alternative treatment approaches are needed. Clinical trial outcomes a novel stimulation device, which is newly available in Europe for patients predominant seizure focus, reported first time. Objective To perform pooled analysis results 2 prospective, multicenter, single-arm trials, A Pilot Study to Assess Feasibility Neurostimulation With EASEE System Treat Medically Refractory Focal Epilepsy (EASEE II) and...
One of the biggest challenges in managing multiple sclerosis is heterogeneity clinical manifestations and progression trajectories. It still remains to be elucidated whether this reflected by discrete immune signatures blood as a surrogate disease pathophysiology. Accordingly, individualized treatment selection based on immunobiological principles not feasible. Using two independent multicentric longitudinal cohorts patients with early ( n = 309 discovery 232 validation), we were able...
Abstract In non‐human primates, invasive tracing and electrostimulation studies have identified strong ipsilateral cortico‐cortical connections between dorsal premotor‐ (PMd) the primary motor cortex (M1 HAND ). Here, we applied dual‐site transcranial magnetic stimulation (dsTMS) to left PMd M1 through specifically designed minicoils selectively probe PMd‐to‐M1 connectivity in humans. A suprathreshold test stimulus (TS) was producing a evoked potential (MEP) of about 0.5 mV relaxed right...
DCC is the receptor for netrin, a protein that guides axon migration of developing neurons across body's midline. Mutations in gene were recently identified 2 families with congenital mirror movements (MM). The objective was to study clinical and genetic characteristics 3 European MM test whether this disorder genetically homogeneous.We studied total 13 affected subjects. Each patient had standardized interview neurologic examination, focusing on phenomenology course MM. severity also...