A5061674092- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Hearing Loss and Rehabilitation
- Multiple Sclerosis Research Studies
- Botulinum Toxin and Related Neurological Disorders
- Migraine and Headache Studies
- Obstructive Sleep Apnea Research
- Sleep and Wakefulness Research
- Neurogenesis and neuroplasticity mechanisms
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Neuroscience of respiration and sleep
- Neuroscience and Neural Engineering
- Trigeminal Neuralgia and Treatments
- Neonatal and fetal brain pathology
- Alzheimer's disease research and treatments
- Heart Rate Variability and Autonomic Control
- Multisensory perception and integration
- Neuroinflammation and Neurodegeneration Mechanisms
- Optical Imaging and Spectroscopy Techniques
Yale University
2022-2025
University of Connecticut
2024-2025
Nathan Kline Institute for Psychiatric Research
2024-2025
Haskins Laboratories
2020-2024
Johannes Gutenberg University Mainz
2015-2023
Sultan Qaboos University
2023
Azienda Socio Sanitaria Territoriale Lariana
2023
University Medical Center of the Johannes Gutenberg University Mainz
2016-2023
ORCID
2021
University of Münster
2020
Cerebello-thalamo-cortical loops play a major role in the emergence of pathological tremors and voluntary rhythmic movements. It is unclear whether these differ anatomically or functionally different types tremor. We compared age- sex-matched groups patients with Parkinson's disease essential tremor healthy controls (n = 34 per group). High-density 256-channel EEG multi-channel EMG from extensor flexor muscles both wrists were recorded simultaneously while extending hands against gravity...
The disruption of pathologically enhanced beta oscillations is considered one the key mechanisms mediating clinical effects deep brain stimulation on motor symptoms in Parkinson's disease. However, a specific modulation other distinct physiological or pathological oscillatory activities could also play an important role symptom control and function recovery during stimulation. Finely tuned gamma have been suggested to be prokinetic nature, facilitating preferential processing neural...
The pathology of multiple sclerosis (MS) consists demyelination and neuronal injury, which occur early in the disease; yet, remission phases indicate repair. Whether how central nervous system (CNS) maintains homeostasis to counteract clinical impairment is not known.We analyse structural connectivity white matter (WM) grey (GM) networks understand absence decline as disease progresses.A total 138 relapsing-remitting MS patients (classified into six groups by duration) 32 healthy controls...
Stroke penumbra injury caused by excess glutamate is an important factor in determining stroke outcome; however, several therapeutic approaches aiming to rescue the have failed, likely due unspecific targeting and persistent excitotoxicity, which continued far beyond primary event. Synaptic lipid signaling can modulate glutamatergic transmission via presynaptic lysophosphatidic acid (LPA) 2 receptors modulated LPA-synthesizing molecule autotaxin (ATX) present astrocytic perisynaptic...
Abstract While deep brain stimulation of the subthalamic nucleus (STN-DBS) has evolved to an evidence-based standard treatment for Parkinson’s disease (PD), targeted cerebral networks are poorly described and no objective predictors postoperative clinical response exist. To elucidate systemic mechanisms DBS, we analysed grey matter properties using cortical thickness measurements addressed dependence structural integrity on outcome. Thirty one patients with idiopathic PD without dementia (23...
Over the first years of life, brain undergoes substantial organization in response to environmental stimulation. In a silent world, it may promote vision by (i) recruiting resources from auditory cortex and (ii) making visual more efficient. It is unclear when such changes occur how adaptive they are, questions that children with cochlear implants can help address. Here, we examined 7-18 old children: 50 had implants, delayed or age-appropriate language abilities, 25 typical hearing...
Early hearing intervention in children with congenital loss is critical for improving auditory development, speech recognition and both expressive receptive language, which translates into better educational outcomes quality of life. In receiving aids or cochlear implants, adaptive potentially maladaptive neural reorganization can mitigate higher-level functions that impact reading. The focus the present study was to dissect underpinnings reading networks implants assess how these mediate...
Abstract Alongside stereotactic magnetic resonance imaging, microelectrode recording (MER) is frequently used during the deep brain stimulation (DBS) surgery for optimal target localization. The aim of this study to optimize subthalamic nucleus (STN) mapping using MER analytical patterns. 16 patients underwent bilateral STN-DBS. was performed simultaneously 5 microelectrodes in a setting Ben’s-gun pattern awake patients. Using spikes and background activity several different parameters their...
Although children with cochlear implants (CI) achieve remarkable success their device, considerable variability remains in individual outcomes. Here, we explored whether auditory evoked potentials recorded during an oddball paradigm could provide useful markers of processing this pediatric population. High-density electroencephalography (EEG) was 75 listening to standard and odd noise stimuli: 25 had normal hearing (NH) 50 wore a CI, divided between high language (HL) low (LL) abilities....
Network science provides powerful access to essential organizational principles of the brain. The aim this study was investigate longitudinal evolution gray matter networks in early relapsing-remitting MS (RRMS) compared with healthy controls (HCs) and contrast network dynamics conventional atrophy measurements.For our study, we investigated structural cortical over 1 year derived from 3T MRI 203 individuals (92 RRMS patients mean disease duration 12.1 ± 14.5 months 101 HCs). Brain were...
Migraine pathophysiology is complex and probably involves cortical subcortical alterations. Structural functional brain imaging studies indicate alterations in the higher order visual cortex patients with migraine. Arterial spin labeling magnetic resonance (ASL-MRI) a non-invasive method for assessing changes cerebral blood flow (CBF) vivo.To examine if interictal CBF differs between episodic migraine (EM) or without aura healthy controls (HC).We assessed using 2D pseudo-continuous ASL-MRI...
Abstract Background Migraine is a primary headache disorder that can be classified into an episodic (EM) and chronic form (CM). Network analysis within the graph-theoretical framework based on connectivity patterns provides approach to observe large-scale structural integrity. We test hypothesis migraineurs are characterized by segregated network. Methods 19 healthy controls (HC), 17 EM patients 12 CM were included. Cortical thickness subcortical volumes computed, topology was analyzed using...
Electroencephalography (EEG) spikes and focal epileptic seizures are generated in circumscribed cerebral networks that have been insufficiently described. For precise time spatial domain network characterization, we applied patients with epilepsy dense array 256-channel EEG recordings causal connectivity estimation by using time-resolved partial directed coherence 3T-magnetic resonance imaging-derived cortical thalamus integrity reconstruction. Before spike generation, significant theta...
Abstract Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease leading to gray matter atrophy brain network reconfiguration as response increasing tissue damage. We evaluated whether white appears subsequently damage, or the degenerates following alterations in networks. MRI data from 83 patients with clinically isolated syndrome early relapsing–remitting MS were acquired at two time points follow‐up after 1 year. White integrity was assessed based on probabilistic...
Parkinson's disease (PD) is a neurodegenerative disease, neuropathologically characterised by progressive loss of neurons in distinct brain areas. We hypothesize that quantifiable network alterations are caused neurodegeneration. The primary motivation this study was to assess the specific PD patients but appear conjunction with physiological aging. 178 subjects (130 females) stratified into patients, young, middle-aged and elderly healthy controls (age- sex-matched patients), were analysed...
We applied longitudinal 3T MRI and advanced computational models in 2 independent cohorts of patients with early MS to investigate how white matter (WM) lesion distribution cortical atrophy topographically interrelate affect functional disability.Clinical disability was measured using the Expanded Disability Status Scale Score at baseline 1-year follow-up a cohort 119 relapsing-remitting replication 81 patients. Covarying patterns were extracted by parallel component analysis. Predictive...
Cochlear implantation (CI) in prelingually deafened children has been shown to be an effective intervention for developing language and reading skill. However, there is a substantial proportion of the receiving CI who struggle with reading. The current study-one first implement electrical source imaging population was designed identify neural underpinnings two groups good poor skill.Data using high density electroencephalography (EEG) under resting state condition obtained from 75 children,...
Abstract Background Deep brain stimulation (DBS) is an effective evidence‐based therapy for dystonia. However, no unequivocal predictors of responses exist. We investigated whether patients optimally responding to DBS present distinct network organization and structural patterns. Methods From a German multicenter cohort 82 dystonia with segmental generalized who received implantation in the globus pallidus internus, we classified based on clinical response 3 years after DBS. Patients were...
Sensory deprivation can offset the balance of audio versus visual information in multimodal processing. Such a phenomenon could persist for children born deaf, even after they receive cochlear implants (CIs), and potentially explain why one modality is given priority over other. Here, we recorded cortical responses to single speaker uttering two syllables, presented audio-only (A), visual-only (V), audio-visual (AV) modes. Electroencephalography (EEG) functional near-infrared spectroscopy...
Abstract Background Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), characterized by inflammatory and neurodegenerative processes. Despite demyelination being a hallmark disease, how it relates to neurodegeneration has still not been completely unraveled, research ongoing into these processes can be tracked non-invasively. Magnetic resonance imaging (MRI) derived brain network characteristics, which closely mirror relate functional impairment, recently...
Studies exploring neuroanatomic correlates of reading have associated white matter tissue properties with disability and related componential skills (e.g., phonological single-word skills). Mean diffusivity (MD) fractional anisotropy (FA) are widely used surrogate measures microstructure high sensitivity; however, they lack specificity for individual microstructural features. Here we investigated neurite features higher in order to explore the underlying architecture. Diffusion weighted...
Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established therapy for Parkinson's disease (PD). However, a more detailed characterization targeted network and its grey matter (GM) terminals that drive clinical outcome needed. In this direction, use MRI after DBS surgery now possible due to recent advances in hardware, opening window clarification association between affected tissue, including white fiber pathways modulated GM regions, DBS-related outcome. Therefore, we...