A5071047920- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Dysraphism and Malformations
- Epilepsy research and treatment
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Pharmacological Effects and Toxicity Studies
- Fetal and Pediatric Neurological Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Pituitary Gland Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Gastrointestinal disorders and treatments
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Neuroblastoma Research and Treatments
- Craniofacial Disorders and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Radiomics and Machine Learning in Medical Imaging
- Genetics and Neurodevelopmental Disorders
- Abdominal vascular conditions and treatments
- Cleft Lip and Palate Research
Ludwig-Maximilians-Universität München
2015-2025
LMU Klinikum
2021-2024
Deutschen Konsortium für Translationale Krebsforschung
2018-2023
Exercise and Survivorship Education Cancer Foundation
2023
Klinikum Stuttgart
2011-2019
München Klinik
2014-2019
Klinik und Poliklinik für Psychosomatik und Psychotherapie
2019
German Cancer Research Center
2011-2018
Zero to Three
2016
Azienda Ospedaliera San Giovanni Addolorata
2011
Molecular imaging studies have recently found inter- and intratumoral heterogeneity in World Health Organization (WHO) grade II gliomas. A correlative analysis with tumor histology, however, is still lacking. For elucidation we conducted the current prospective study. Fifty-five adult patients an MRI-based suspicion of a WHO glioma were included. [F-18]Fluoroethyltyrosine (18FET) uptake kinetic combined frame-based stereotactic localization techniques used as guide for stepwise (1-mm steps)...
Importance For the large population of people with drug-refractory epilepsy, alternative treatment approaches are needed. Clinical trial outcomes a novel stimulation device, which is newly available in Europe for patients predominant seizure focus, reported first time. Objective To perform pooled analysis results 2 prospective, multicenter, single-arm trials, A Pilot Study to Assess Feasibility Neurostimulation With EASEE System Treat Medically Refractory Focal Epilepsy (EASEE II) and...
In suspected grade II gliomas, three distinct patterns of time-activity curves (TAC) on O-(2-[(18)F]fluoroethyl)-1-tyrosine ((18)F-FET) positron emission tomography (PET) have been delineated (i) increasing TAC homogeneously throughout the tumor, and decreasing TAC, (ii) either tumor or (iii) only focally within otherwise patterns. Increasing was associated with low-grade histology high-grade histology. This prospective study analyzed whether these correlate biological subtypes differential...
Abstract Objective Epilepsy surgery is a standard treatment for drug‐resistant epilepsy, resulting in seizure freedom significant number of cases. Although frequently performed low‐grade brain tumors, it rarely considered high‐grade despite the impact chronic epilepsy on quality life and cognition. Methods This retrospective multicenter study across 43 European centers evaluated outcomes children with tumors (World Health Organization grades III IV). Two cohorts patients younger than 25...
Abstract Objective Heterozygous mutations within the voltage-gated sodium channel α subunit ( SCN1A ) are responsible for majority of cases Dravet syndrome (DS), a severe developmental and epileptic encephalopathy. Development novel therapeutic approaches is mandatory in order to directly target molecular consequences genetic defect. The aim present study was investigate whether cis-acting long non-coding RNAs (lncRNAs) expressed brain specimens children adolescent with epilepsy as these...
OBJECTIVE Sinus-preserving (SP) embolization techniques augment endovascular treatment options for intracranial lateral dural arteriovenous fistulas (DAVFs). The authors aimed to perform a retrospective comparison of their primary success rates, complication and long-term follow-up with those sinus-occluding (SO) variants in the collective low- intermediate-grade DAVFs (Cognard Types I-IIb). METHODS Clinical symptoms, Cognard grading prior after DAVF using different technical approaches was...
ABSTRACT BACKGROUND AND PURPOSE Brain edema after acute cerebral lesions may lead to raised intracranial pressure (ICP) and worsen outcome. Notwithstanding, no CT‐based scoring system quantify formation exists. This retrospective correlative analysis aimed establish a valid definite CT score quantifying brain common lesions. METHODS A total of 169 investigations in 60 patients were analyzed: traumatic injury (TBI; n = 47), subarachnoid hemorrhage (SAH; 70), intracerebral (ICH; 42), ischemic...
We aimed to elucidate the place of dynamic O-(2-[18F]-fluoroethyl)-L-tyrosine (18F-FET) PET in prognostic models gadolinium (Gd)-negative gliomas.In 98 patients with Gd-negative gliomas undergoing 18F-FET guided biopsy, time activity curves (TACs) each tumor were qualitatively categorized as either increasing or decreasing. Additionally, post-hoc quantitative analyses done using minimal time-to-peak (TTPmin) measurements. Prognostic factors obtained from multivariate hazards models. The fit...
OBJECT Treatment of skull base lesions is complex and usually requires a multidisciplinary approach. In meningioma, which the most common tumor entity in this region, resection considered to be important therapeutic step avoid recurrence. However, with orbital or optic nerve involvement poses challenge due their anatomical structure proximity eloquent areas. Therefore main goal surgery should achieve maximum extent while preserving neurological function. postoperative course, medical...
Objective Treatment strategies for craniopharyngiomas are still under debate particularly the young population. We here present tumor control and functional outcome data after surgical treatment focusing on stereotactic microsurgical procedures cystic in children adolescents. Methods From our prospective institutional database, we identified all consecutive patients less than 18 years of age who were surgically treated newly-diagnosed craniopharyngioma between, 2000 and, 2022. decisions...
Abstract BACKGROUND: Prognosis and treatment of cystic craniopharyngiomas are poorly defined. OBJECTIVE: To analyze progression-free survival (PFS) safety profile undergoing resection or minimally invasive drainage procedures. We compared further outcome measurements for solid tumors to elucidate the impact initial tumor composition on both PFS toxicity profile. METHODS: All patients with consecutively treated between 1999 2014 were included. A decision in favor microsurgery stereotactic was...
Background Chiari I malformation typically presents with cough headache. However, migraine-like or tension-type-like headaches may also occur. There are limited publications on malformation-associated headache semiologies and the effect of foramen magnum decompression different types. Methods A retrospective analysis complemented by structured phone interviews was performed 65 patients malformation, treated at our hospital between 2010 2021. Headache semiology (according to ICHD-3),...
Abstract Pathogenic variants in COL4A1, encoding the α chain of type IV collagen, have been associated with cerebrovascular pathology as well malformations cortical development, thereby causing structural epilepsy. This case illustrates successful resective epilepsy surgery a 12-month-old girl left occipital focal dysplasia (FCD) heterozygous splice-donor variant COL4A1. She presented drug-resistant daily seizures from age 2 months, refractory to several combinations antiseizure medications,...
Abstract Objective The best treatment strategies for cerebral arachnoid cysts (CAC) are still up debate. In this study, we present CAC management, outcome data, and risk factors recurrence after surgical treatment, focusing on microscopic/endoscopic approaches as compared to minimally invasive stereotactic procedures in children adults. Methods our single-institution retrospective database, identified all patients treated surgically newly diagnosed between 2000 2022. Microscopic/endoscopic...
Endoscopic third ventriculostomy is the treatment of choice in patients with obstructive hydrocephalus caused by aqueductal stenosis. The authors examined clinical course and results surgical for pre- postoperative refined constructive interference steady-state (CISS) MR imaging.Forty underwent 3D-CISS imaging evaluation. Radiological findings were correlated intraoperative observations thickness transparency floor ventricle patient's course.Three-dimensional CISS provides precise...
Bradykinin (BK) was shown to stimulate the production of physiologically active metabolites, blood-brain barrier disruption, and brain edema. The aim this prospective study measure BK concentrations in blood cerebrospinal fluid (CSF) patients with traumatic injury (TBI), subarachnoid hemorrhage (SAH), intracerebral (ICH), ischemic stroke correlate levels extent cerebral edema intracranial pressure (ICP). Blood CSF samples 29 suffering from acute lesions (TBI, 7; SAH,: 10; ICH, 8; stroke, 4)...
Background. Treatment of Chiari malformation can include suboccipital decompression with resection one cerebellar tonsil. Its effects on ocular motor and function have not yet been systematically examined. Objective. To investigate whether decompression, including tonsil, leads to motor, vestibular or deficits. Patients Methods. Ten patients type 1 were examined before after (one week three months) unilateral tonsillectomy. The work-up included a neurological neuro-ophthalmological...
Abstract Background Supratentorial intraventricular tumors (SIVTs) are rare lesions of various entities characteristically presenting with hydrocephalus and often posing a surgical challenge due to their deep-seated localization. We aimed elaborate on shunt dependency after tumor resection, clinical characteristics, perioperative morbidity. Methods retrospectively searched the institutional database for patients supratentorial treated at Department Neurosurgery Ludwig-Maximilians-University...