A5102958740- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Ophthalmology and Eye Disorders
- Neurological Complications and Syndromes
- Psychosomatic Disorders and Their Treatments
- Vagus Nerve Stimulation Research
- Cardiovascular Syncope and Autonomic Disorders
- Botulinum Toxin and Related Neurological Disorders
- Vestibular and auditory disorders
- Neurosurgical Procedures and Complications
- Obsessive-Compulsive Spectrum Disorders
- Body Image and Dysmorphia Studies
- Transcranial Magnetic Stimulation Studies
- Pain Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Muscle activation and electromyography studies
- Cerebral Venous Sinus Thrombosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Heart Rate Variability and Autonomic Control
- Long-Term Effects of COVID-19
- Multiple Sclerosis Research Studies
- Glaucoma and retinal disorders
- Pain Management and Treatment
- Musculoskeletal pain and rehabilitation
Ludwig-Maximilians-Universität München
2016-2025
LMU Klinikum
2006-2025
Kliniken des Bezirks Oberbayern
2023-2025
Klinik und Poliklinik für Neurologie
1990-2024
München Klinik
2018-2024
New York Proton Center
2020
American Headache Society
2020
Technische Universität Dresden
2015
Heidelberg University
2013
Institut für Urheber- und Medienrecht
2011
Using MRI and voxel-based morphometry, the authors investigated 20 patients with chronic tension type headache (CTTH) medication-overuse compared them to 40 controls no history. Only CTTH demonstrated a significant gray matter decrease in regions known be involved pain processing. The finding implies that alterations are specific rather than response head or chronification per se.
Aim of the study was assessment efficacy and safety transcutaneous stimulation auricular branch vagal nerve (t-VNS) in treatment chronic migraine. A monocentric, randomized, controlled, double-blind conducted. After one month baseline, migraine patients were randomized to receive 25 Hz or 1 sensory area at left ear by a handhold battery driven stimulator for 4 h/day during 3 months. Headache days per 28 compared between baseline last number with acute medication recorded The Impact Test...
Background Chronic cluster headache (CH) is a debilitating disorder for which few well-controlled studies demonstrate effectiveness of available therapies. Non-invasive vagus nerve stimulation (nVNS) was examined as adjunctive prophylactic treatment chronic CH. Methods PREVA prospective, open-label, randomised study that compared nVNS ( n = 48) with standard care (SoC) alone (control 49)). A two-week baseline phase followed by four-week (SoC plus vs control) and extension nVNS). The primary...
Background Clinical observations and results from recent studies support the use of non-invasive vagus nerve stimulation (nVNS) for treating cluster headache (CH) attacks. This study compared nVNS with a sham device acute treatment in patients episodic or chronic CH (eCH, cCH). Methods After completing 1-week run-in period, subjects were randomly assigned (1:1) to receive therapy during 2-week double-blind period. The primary efficacy endpoint was proportion all treated attacks that achieved...
Based on concepts that endogenous opioids participate in neural transmission of pain, the present study central poststroke pain (CPSP) patients investigated changes opioid receptor (OR) binding structures centrally involved processing pain. Five with after lesions brain stem, thalamus or parietal cortex and twelve healthy volunteers underwent a [11C]diprenorphine positron emission tomography study. Binding potentials were calculated using reference region model all subjects. Statistical...
Monoclonal antibodies targeting the CGRP pathway are effective and safe for prophylactic treatment of episodic (EM) chronic migraine (CM). In case failure a mAb, physician has to decide whether using another anti-CGRP mAb is useful. This interim analysis Finesse Study evaluates effectiveness fremanezumab in patients with history other prior treatments (switch patients).FINESSE, non-interventional, prospective, multicentre, two-country (Germany-Austria) study observing receiving clinical...
To determine the spectrum and frequency of neurologic sequelae after allogeneic bone marrow transplantation (BMT) to define a risk profile patients.A prospective follow-up 71 recipients 14 +/- 3 months transplantation. Patients underwent examination, neuropsychological test battery, cranial MRI before BMT.A large proportion patients (65%) developed BMT. Acute complications defined etiology occurred in 18% led death 9% study population. A total 47% new abnormalities undefined origin that were...
<b><i>Objective:</i></b> To determine whether the cytokine tumor necrosis factor α (TNF-α) acts as a pain mediator in neuropathic humans. <b><i>Background:</i></b> In animal models, inflammatory cytokines such TNF-α have been shown to facilitate pain. <b><i>Methods:</i></b> The expression of was analyzed immunohistochemically 20 human nerve biopsy specimens patients with painful (n = 10) and nonpainful neuropathies. Additionally, serum soluble receptor I (sTNF-RI) levels were determined 24...
Cluster headache is a form of primary in which attacks are rapid onset with very severe pain. The mainstays acute therapy inhaled oxygen and sumatriptan succinate injection.To evaluate zolmitriptan nasal spray the treatment cluster headache.Ninety-two patients, aged 40 +/- 10 years (mean SD) (80 men 12 women), International Headache Society-defined were randomized into placebo-controlled, double-blind crossover study. Patients treated 3 using placebo for 1 attack, 5 mg (ZNS5) attack. end...
The clinical overlap between monogenic Familial Hemiplegic Migraine (FHM) and common migraine subtypes, the fact that all three FHM genes are involved in transport of ions, suggest ion may underlie susceptibility to forms migraine. To test this leading hypothesis, we examined variation 155 using 5257 single nucleotide polymorphisms (SNPs) a Finnish sample 841 unrelated with aura cases 884 non-migraine controls. top signals were then tested for replication four independent case–control...
In collaboration with some of the leading headache centres in Germany, Switzerland and Austria, we have established new guidelines for treatment migraine attacks prevention migraine. A thorough literature research last 10 years has been basis current recommendations. At beginning, present therapeutic novelties, followed by a summary all After an introduction, cover topics like drug therapy practical experience, non-effective medication, prevention, interventional methods, non-medicational...
Patients with visual snow syndrome (VS) suffer from a debilitating continuous disturbance of unknown mechanism. The present study tested the hypothesis dysfunctional processing using evoked potentials. Eighteen patients were compared to age‐matched migraineurs (M) and healthy controls (C) 2‐way analysis variance group (VS, M, C) gender as factors. Visual potentials VS demonstrated increased N145 latency (in milliseconds, VS: 152.7 ± 7.9 vs M: 145.3 9.8 C: 145.5 9.4; F = 3.28; p 0.046)...
Background Calcitonin gene-related peptide (CGRP) released from trigeminal nerve fibres indicates activation and has a key role in migraine pathophysiology. The directly innervates the eye. Therefore, this study, we compared tear fluid of patients healthy controls. Methods concentrations plasma 48 episodic 45 chronic controls were assessed using ELISA. Results levels (0.94 ± 1.11 ng/ml) ∼140 times higher than (6.81 4.12 pg/ml). Tear CGRP elevated interictal (1.10 1.27 ng/ml, n = 49) to (0.75...
We evaluated telmisartan 80 mg for migraine prophylaxis. Migraine patients ( n = 95) with three to seven attacks in 3 months were randomized, double-blind or placebo. The primary end-point was the reduction number of days (i.e. a day ≥ 1 h symptoms) between 4-week baseline period and last 4 weeks 12-week treatment period. A responder recorded when there symptom 50% these periods. 1.65 1.14 placebo P > 0.05). Post hoc analyses adjusting centre showed 38% vs. 15% 0.03), borderline...
Thunderclap headache (TCH) is a neurological emergency that warrants immediate and comprehensive diagnostic determination. When no pathology can be identified the condition classified as primary TCH, which considered benign self-limiting. TCH has also been reported initial symptom of reversible cerebral vasoconstriction syndrome (RCVS), subsumes variety conditions, inconsistently coined Call-Flemming syndrome, angiopathy central nervous system, drug-induced arteritis, or migrainous...
Bone marrow edema (BME) is a descriptive term for common finding in magnetic resonance imaging (MRI). Although pain the major symptom, BME differs terms of its causal mechanisms, underlying disease, as well treatment and prognosis. This complexity together with lack evidence-based guidelines, frequently makes identification conditions management challenge. Unnecessary multiple consultations delays diagnosis therapy indicate need interdisciplinary clinical recommendations. Therefore, an task...
Abstract Background With headache experienced by up to 75% of adults worldwide in the last year, primary disorders constitute a major public health problem, yet they remain under-diagnosed and under-treated. Headache prevalence burden is changing as society evolves, with now occurring earlier life. Contributing factors, mostly associated life style, such stress, bad posture, physical inactivity, sleep disturbance, poor diet excess use digital technology may be phenomenon that could labelled...
Background and Purpose —There is only limited information about late neurological complications after bone marrow transplantation (BMT). The purpose of this study to describe a cerebral angiitis-like syndrome allogeneic BMT. Methods —Clinical diagnostic findings 5 BMT patients with chronic graft versus host disease neuropathological data 1 patient were reported. Results —In the described patients, focal signs neuropsychological abnormalities occurred years MRI revealed periventricular white...