Sergio E. Baranzini
A5014721690- Multiple Sclerosis Research Studies
- Bioinformatics and Genomic Networks
- Cytokine Signaling Pathways and Interactions
- Gut microbiota and health
- Gene expression and cancer classification
- Systemic Lupus Erythematosus Research
- Biomedical Text Mining and Ontologies
- Genetic Associations and Epidemiology
- T-cell and B-cell Immunology
- RNA Research and Splicing
- Olfactory and Sensory Function Studies
- RNA regulation and disease
- Advanced Chemical Sensor Technologies
- Viral Infections and Immunology Research
- Immunotherapy and Immune Responses
- Gene Regulatory Network Analysis
- Immune Cell Function and Interaction
- Computational Drug Discovery Methods
- Clostridium difficile and Clostridium perfringens research
- MicroRNA in disease regulation
- interferon and immune responses
- T-cell and Retrovirus Studies
- Neurogenesis and neuroplasticity mechanisms
- Rheumatoid Arthritis Research and Therapies
- Neuroinflammation and Neurodegeneration Mechanisms
University of California, San Francisco
2016-2025
Universidad Católica de Santa Fe
2024
University of Cambridge
2022
Aberdeen Royal Infirmary
2021
NHS Grampian
2021
QB3
2021
Brigham and Women's Hospital
2020
Universidad San Pablo
2020
Broad Institute
2020
McGill University
2014-2020
We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects established a reference map the architecture MS that includes 200 autosomal susceptibility variants outside major histocompatibility complex (MHC), one chromosome X variant, 32 within extended MHC. used an ensemble methods to prioritize 551 putative genes implicate innate adaptive pathways distributed across cellular components immune system. Using expression profiles from purified human microglia, we...
Significance We have experimentally investigated the immunoregulatory effects of human gut microbiota in multiple sclerosis (MS). identified specific bacteria that are associated with MS and demonstrated these regulate T lymphocyte-mediated adaptive immune responses contribute to proinflammatory environment vitro vivo. Thus, our results expand knowledge microbial regulation immunity may provide a basis for development microbiome-based therapeutics autoimmune diseases.
There is emerging evidence that the commensal microbiota has a role in pathogenesis of multiple sclerosis (MS), putative autoimmune disease CNS. Here, we compared gut microbial composition 34 monozygotic twin pairs discordant for MS. While there were no major differences overall profiles, found significant increase some taxa such as Akkermansia untreated MS twins. Furthermore, most notably, when transplanted to transgenic mouse model spontaneous brain autoimmunity, twin-derived induced...
Multiple sclerosis is a demyelinating disease, characterized by inflammation in the brain and spinal cord, possibly due to autoimmunity. Large-scale sequencing of cDNA libraries, derived from plaques dissected brains patients with multiple (MS), indicated an abundance transcripts for osteopontin (OPN). Microarray analysis cords rats paralyzed experimental autoimmune encephalomyelitis (EAE), model MS, also revealed increased OPN transcripts. Osteopontin-deficient mice were resistant...
The progressive loss of CNS myelin in patients with multiple sclerosis (MS) has been proposed to result from the combined effects damage oligodendrocytes and failure remyelination. A common feature demyelinated lesions is presence oligodendrocyte precursors (OLPs) blocked at a premyelinating stage. However, mechanistic basis for inhibition repair incompletely understood. To identify novel regulators OLP differentiation, potentially dysregulated during repair, we performed genome-wide screen...
The discovery and broad application of MRI in medicine has led to an increased awareness the number patients with incidental white matter pathology CNS. Routinely encountered clinical practice, natural history or evolution such individuals respect their risk developing multiple sclerosis (MS) is unclear.To investigate who exhibit imaging findings highly suggestive MS pathology.Detailed radiologic data were obtained from asymptomatic anomalies MS.The cohort consisted 41 female 3 male subjects...
Identical (or more correctly 'monozygotic') twins are widely used to study the contributions of genetics and environment human disease. A that focused on three pairs monozygotic twins, in which one twin had multiple sclerosis other did not, has brought latest techniques genome sequencing analysis this field, incidentally published first female sequences. Full sequences were determined for pair these two mRNA transcriptome epigenome CD4+ lymphocytes determined. The striking result is no...
Multiple sclerosis (MS), a chronic disorder of the central nervous system and common cause neurological disability in young adults, is characterized by moderate but complex risk heritability. Here we report results genome-wide association study performed 1000 prospective case series well-characterized individuals with MS group-matched controls using Sentrix® HumanHap550 BeadChip platform from Illumina. After stringent quality control data filtering, compared allele frequencies for 551 642...
The ability to computationally predict whether a compound treats disease would improve the economy and success rate of drug approval. This study describes Project Rephetio systematically model efficacy based on 755 existing treatments. First, we constructed Hetionet (neo4j.het.io), an integrative network encoding knowledge from millions biomedical studies. v1.0 consists 47,031 nodes 11 types 2,250,197 relationships 24 types. Data were integrated 29 public resources connect compounds,...
To characterize the accrual of long-term disability in a cohort actively treated multiple sclerosis (MS) patients and to assess whether clinical magnetic resonance imaging (MRI) data used trials have prognostic value.This is prospective study 517 managed MS enrolled at single center.More than 91% were retained, with ascertained up 10 years after baseline visit. At this last assessment, neurologic as measured by Expanded Disability Status Scale (EDSS) was stable or improved compared 41%...
Genome-wide association studies (GWAS) testing several hundred thousand SNPs have been performed in multiple sclerosis (MS) and other complex diseases. Typically, the number of markers which evidence for exceeds genome-wide significance threshold is very small, that do not exceed this are generally neglected. Classical statistical analysis these datasets MS revealed genes with known immunological functions. However, many showing modest may represent false negatives. We hypothesize certain...
Objective Rates of worsening and evolution to secondary progressive multiple sclerosis (MS) may be substantially lower in actively treated patients compared natural history studies from the pretreatment era. Nonetheless, our recently reported prospective cohort, more than half with relapsing MS accumulated significant new disability by 10th year follow‐up. Notably, “no evidence disease activity” at 2 years did not predict long‐term stability. Here, we determined what extent clinical relapses...
Abstract In multiple sclerosis (MS), B cell–depleting therapy using monoclonal anti-CD20 Abs, including rituximab (RTX) and ocrelizumab, effectively reduces disease activity. Based on indirect evidence, it is generally believed that elimination of the Ag-presenting capabilities Ag nonspecific immune functions cells underlie therapeutic efficacy. However, a small subset T lymphocytes (T cells) was shown to also express CD20, but controversy prevails surrounding true existence this cell...