Miriam Zuccalà
A5085895479- T-cell and B-cell Immunology
- interferon and immune responses
- Evolution and Genetic Dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
- Multiple Sclerosis Research Studies
- Chromosomal and Genetic Variations
- Wheat and Barley Genetics and Pathology
- Atherosclerosis and Cardiovascular Diseases
- Amyotrophic Lateral Sclerosis Research
- Calcium signaling and nucleotide metabolism
- Neurogenetic and Muscular Disorders Research
- Protein Degradation and Inhibitors
- Inflammatory Bowel Disease
- Mycobacterium research and diagnosis
- Plant Virus Research Studies
- Immune Response and Inflammation
- Endoplasmic Reticulum Stress and Disease
- Immunotherapy and Immune Responses
- Genetic Syndromes and Imprinting
- Gut microbiota and health
- Ion Channels and Receptors
- RNA Research and Splicing
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2017-2022
Consorzio Interuniversitario per le Biotecnologie
2021
We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects established a reference map the architecture MS that includes 200 autosomal susceptibility variants outside major histocompatibility complex (MHC), one chromosome X variant, 32 within extended MHC. used an ensemble methods to prioritize 551 putative genes implicate innate adaptive pathways distributed across cellular components immune system. Using expression profiles from purified human microglia, we...
Abstract: We assembled and analyzed genetic data of 47,351 multiple sclerosis (MS) subjects 68,284 control establish a reference map the architecture MS that includes 200 autosomal susceptibility variants outside major histocompatibility complex (MHC), one chromosome X variant, 32 independent associations within extended MHC. used an ensemble methods to prioritize up 551 potentially associated genes, implicate innate adaptive pathways distributed across cellular components immune system....
Genome-wide association studies identified over 200 risk loci for multiple sclerosis (MS) focusing on common variants, which account about 50% of disease heritability. The goal this study was to investigate whether low-frequency and rare functional located in MS-established associated loci, may contribute a relatively homogeneous population, testing their cumulative effect (burden) with gene-wise tests. We sequenced 98 genes 588 Italian patients MS 408 matched healthy controls (HCs)....
Approximately 50% of colorectal cancer (CRC) patients still die from recurrence and metastatic disease, highlighting the need for novel therapeutic strategies. Drug repurposing is attracting increasing attention because, compared to traditional de novo drug discovery processes, it may reduce development periods costs. Epidemiological preclinical evidence support antitumor activity antipsychotic drugs. Herein, we dissect mechanism action typical spiperone in CRC. Spiperone can clonogenic...
Known multiple sclerosis (MS) susceptibility variants can only explain half of the disease’s estimated heritability, whereas low-frequency and rare may partly account for missing heritability. Thus, here we sought to determine occurrence functional in a large Italian MS multiplex family with five affected members. For this purpose, combined linkage analysis next-generation sequencing (NGS)-based whole exome genome (WES WGS, respectively). The genetic burden attributable known common was also...
SummaryBackground and aimsThe association between lifestyle factors Multiple Sclerosis (MS) disease severity progression has been investigated to a lesser extent compared with susceptibility the disease. We aimed assess impact of lifetime coffee tea consumption on MS severity.MethodsDesign: cross-sectional study. Two hundred eight patients (139 females 69 males) consecutively recruited at Department Neurology in Novara, Italy were asked about their tea. The intensity (cups/day) was estimated...