A5039258653- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Clostridium difficile and Clostridium perfringens research
- Anesthesia and Neurotoxicity Research
- Wheat and Barley Genetics and Pathology
- COVID-19 Impact on Reproduction
- Neonatal Health and Biochemistry
- Hip and Femur Fractures
- Maternal Mental Health During Pregnancy and Postpartum
- Bacterial Identification and Susceptibility Testing
- Chromosomal and Genetic Variations
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- COVID-19 and healthcare impacts
- Heparin-Induced Thrombocytopenia and Thrombosis
- Liver Disease and Transplantation
- Evolution and Genetic Dynamics
- Calcium signaling and nucleotide metabolism
- Inflammatory Bowel Disease
- Frailty in Older Adults
- Vitamin K Research Studies
Ospedale dei Bambini Vittore Buzzi
2024
University of Milan
2023-2024
University of Modena and Reggio Emilia
2019-2023
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2021-2022
Azienda Ospedaliero-Universitaria di Modena
2020-2021
National Cancer Center
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
According to the American Society of Anesthe-siologists (ASA), a monitored anesthesia care (MAC) is planned procedure during which patient undergoes local together with sedation and analgesia. Actually MAC first choice in 10-30% all surgical procedures. The 3 fundamental elements purposes conscious are: safe sedation, control anxiety pain control. patients undergoing are able answer orders appropriately protect airways. Last but not least, another purpose any get satisfied, allowing him his...
Abstract We report two fatal cases of acute liver failure secondary to herpes simplex virus 1 infection in COVID-19 patients, following tocilizumab and corticosteroid therapy. Screening for prompt recognition reactivation these undergoing immunomodulatory treatment, may have potentially relevant clinical consequences.
Abstract: Infections by multidrug resistant bacteria (MDR) occur frequently in patients admitted to intensive care unit (ICU) with incidence up 40% many world regions and are usually associated high mortality. In ICU patients, numerous independent risk factors for infections MDR have been identified whose careful management an appropriate use of antibiotics fundamental. Despite the latter may results challenging cases, combination old novel permits provide vitro effective strategy also more...
Introduction Inherited metabolic diseases (IMDs) represent a major clinical challenge, especially during the neonatal and infant periods. They require tailored long-term nutritional management to ensure proper growth development. Protein substitutes are essential in dietary treatment of IMDs, particularly aminoacidopathies, organic acidemias, urea cycle disorders. In Italy, variety PSs is available for infants with IMDs requiring controlled protein and/or amino acid intake; however,...
Abstract Objectives The identification of vitamin B12 (B12) deficiency in the newborn may prevent neurological damage and a delay normal growth. In this study we characterized incidence newborns, costs associated to clinical diagnosis management, relevance optimize use cobalamin biomarkers during treatment follow-up. Methods Starting from continuous case series 146,470 screened newborns (November, 1st 2021- December, 3rd 2023), Regional Reference Laboratory for Neonatal Screening identified...
The aim of our study was to evaluate whether the introduction SDD in a structured protocol for VAP prevention effective reducing occurrence ventilator-associated pneumonia (VAP) COVID-19 patients without changes microbiological pattern antibiotic resistance. This observational pre-post included adult requiring invasive mechanical ventilation (IMV) severe respiratory failure related SARS-CoV-2 admitted three intensive care units (ICUs) an Italian hospital from 22 February 2020 8 March 2022....
Introduction: The activity and regulation of inflammasome is receiving increasing attention in septic shock. Moreover, there a growing body evidence suggesting that mitochondrial DNA (mtDNA) can play role as biomarker disease severity even mortality both adults children critically ill setting. However, no data are available on the amount circulating mtDNA gene expression multi-drug resistant (MDR) bacteria For this reason, aim study was to determine whether plasma levels monocytes could be...
Introduction In patients with septic shock, low levels of circulating immunoglobulins are common and their kinetics appear to be related clinical outcome. The pivotal role in the host immune response infection suggests that additional therapy polyclonal intravenous may a promising option shock. Immunoglobulin preparations enriched IgM component have largely been used sepsis, mostly at standard dosages (250 mg/kg per day), regardless severity without any dose adjustment based on...
Approximately 50% of colorectal cancer (CRC) patients still die from recurrence and metastatic disease, highlighting the need for novel therapeutic strategies. Drug repurposing is attracting increasing attention because, compared to traditional de novo drug discovery processes, it may reduce development periods costs. Epidemiological preclinical evidence support antitumor activity antipsychotic drugs. Herein, we dissect mechanism action typical spiperone in CRC. Spiperone can clonogenic...
Known multiple sclerosis (MS) susceptibility variants can only explain half of the disease’s estimated heritability, whereas low-frequency and rare may partly account for missing heritability. Thus, here we sought to determine occurrence functional in a large Italian MS multiplex family with five affected members. For this purpose, combined linkage analysis next-generation sequencing (NGS)-based whole exome genome (WES WGS, respectively). The genetic burden attributable known common was also...
Abstract Background The use of cytokine-blocking agents has been proposed to modulate the inflammatory response in patients with COVID19. Tocilizumab and Anakinra were included local protocol as an optional treatment critically ill acute respiratory distress syndrome (ARDS) by SARS-CoV2 infection. This cohort study evaluated effects therapy cytokine blocking on in-hospital mortality COVID19 requiring mechanical ventilation admitted intensive care unit. Methods association between or was...
Abstract Background The use of cytokine-blocking agents has been proposed to modulate the inflammatory response in patients with COVID19. Tocilizumab and Anakinra were included local protocol as an optional treatment critically ill acute respiratory distress syndrome (ARDS) by SARS-CoV2 infection. This cohort study evaluated effects therapy cytokine blocking on in-hospital mortality COVID19 requiring mechanical ventilation admitted intensive care unit. Methods association between or was...