A5002566819- Food Allergy and Anaphylaxis Research
- Eosinophilic Esophagitis
- Gut microbiota and health
- Probiotics and Fermented Foods
- Infant Nutrition and Health
- Digestive system and related health
- Allergic Rhinitis and Sensitization
- Liver Disease Diagnosis and Treatment
- Infant Health and Development
- Asthma and respiratory diseases
- Diet, Metabolism, and Disease
- Child Nutrition and Feeding Issues
- Pediatric health and respiratory diseases
- Contact Dermatitis and Allergies
- Pediatric Urology and Nephrology Studies
- Vitamin D Research Studies
- Diet and metabolism studies
- Urinary Tract Infections Management
- Viral gastroenteritis research and epidemiology
- Metabolism and Genetic Disorders
- Multiple Sclerosis Research Studies
- Epigenetics and DNA Methylation
- Total Knee Arthroplasty Outcomes
- Congenital gastrointestinal and neural anomalies
- Birth, Development, and Health
Guglielmo da Saliceto Hospital
2020-2024
University of Parma
2023-2024
Ospedale degli Infermi
2024
ASL Roma
2024
Federico II University Hospital
2019-2021
University of Naples Federico II
2011-2020
Ceinge Biotecnologie Avanzate (Italy)
2019-2020
Institut thématique Génétique, génomique et bioinformatique
2018
ENT and Allergy
2018
University of Lausanne
2018
Butyrate is a short chain fatty acid derived from the microbial fermentation of dietary fibers in colon. In last decade, multiple beneficial effects butyrate at intestinal and extraintestinal level have been demonstrated. The mechanisms action are different many these involve an epigenetic regulation gene expression through inhibition histone deacetylase. There growing interest because its impact on will lead to more specific efficacious therapeutic strategies for prevention treatment...
BackgroundChildren with cow's milk allergy (CMA) have an increased risk of other allergic manifestations (AMs).ObjectiveWe performed a parallel-arm randomized controlled trial to test whether administration extensively hydrolyzed casein formula (EHCF) containing the probiotic Lactobacillus rhamnosus GG (LGG) can reduce occurrence AMs in children CMA.MethodsChildren IgE-mediated CMA were randomly allocated EHCF or EHCF+LGG groups and followed for 36 months. The main outcome was at least 1 AM...
DNA methylation of the Th1 and Th2 cytokine genes is altered during cow's milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) essential for development function regulatory T cells (Tregs) involved in oral tolerance acquisition. We assessed whether acquisition children with IgE-mediated CMA associated demethylation Treg-specific demethylated region (TSDR) FoxP3. Forty (aged 3–18 months) were enrolled: 10 active (group 1), who outgrew after dietary treatment an extensively...
Food allergy (FA) is a growing health problem worldwide. Effective strategies are advocated to limit the disease burden. Human milk (HM) could be considered as protective factor against FA, but its mechanisms remain unclear. Butyrate gut microbiota-derived metabolite able exert several immunomodulatory functions. We aimed define butyrate concentration in HM, and see whether detected HM modulate of immune tolerance.HM from 109 healthy women was assessed by GS-MS. The effect on tolerogenic...
Epigenetic changes in DNA methylation could regulate the expression of several allergy-related genes. We investigated whether tolerance acquisition children with immunoglobulin E (IgE)-mediated cow's milk allergy (CMA) is characterized by a specific profile Th2 (IL-4, IL-5) and Th1 (IL-10, IFN-γ)-associated cytokine genes.DNA CpGs promoting regions genes from peripheral blood mononuclear cells serum level IL-4, IL-5, IL-10 INF-γ were assessed active IgE-mediated CMA (group 1), who acquired...
Abstract Epigenetic mechanisms could drive the disease course of cow’s milk allergy (CMA) and formula choice modulate these pathways. We compared effect two different dietary approaches on epigenetic in CMA children. Randomized controlled trial IgE-mediated children receiving a 12-month treatment with extensively hydrolyzed casein containing probiotic L.rhamnosus GG (EHCF + LGG) or soy (SF). At baseline, after 6 12 months FoxP3 methylation rate its expression CD4 T cells were assessed. same...
Summary Background Acute diarrhoea is a frequent problem in children with heavy economic burden for families and society. Aim To test the efficacy of new synbiotic formulation containing L actobacillus paracasei B21060, arabinogalactan xilooligosaccharides acute diarrhoea. Methods Double‐blind, randomised, placebo‐controlled trial, including (age 3–36 m) who were allocated to placebo or group. Major outcome was resolution rate at 72 h. Total duration diarrhoea, daily stool outputs,...
Abstract Background Extensively hydrolyzed casein formula ( EHCF ) has been proposed for the prevention and is commonly used treatment of cow's milk allergy CMA ). The addition probiotic Lactobacillus rhamnosus GG LGG to may induce faster acquisition tolerance milk. mechanisms underlying this effect are largely unexplored. We investigated effects alone or in combination with on β‐lactoglobulin BLG sensitization mice. Methods Three‐week‐old C3H/HeOuJ mice were sensitized by oral...
Introduction Inherited metabolic diseases (IMDs) represent a major clinical challenge, especially during the neonatal and infant periods. They require tailored long-term nutritional management to ensure proper growth development. Protein substitutes are essential in dietary treatment of IMDs, particularly aminoacidopathies, organic acidemias, urea cycle disorders. In Italy, variety PSs is available for infants with IMDs requiring controlled protein and/or amino acid intake; however,...
Abstract Atopy patch tests ( APT s) have been proposed for the diagnostic approach in children with non‐IgE‐mediated cow's milk allergy and gastrointestinal symptoms. We aimed to investigate benefit of s predicting oral tolerance these patients. prospectively evaluated 172 subjects a sure diagnosis CMA symptoms (97 boys, 56.4%; age, 6.37 m; range, 2–12 m). At diagnosis, 113/172 (65.7%) had positive proteins CMP ). After 12 months exclusion, diet were repeated immediately before OFC ....