A5031664151- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- CNS Lymphoma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Cytomegalovirus and herpesvirus research
- Polyomavirus and related diseases
- Eosinophilic Disorders and Syndromes
- Acute Lymphoblastic Leukemia research
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Parvovirus B19 Infection Studies
- Immune Cell Function and Interaction
- Advanced Breast Cancer Therapies
- HIV Research and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Ethics in Clinical Research
- Acute Myeloid Leukemia Research
- Histiocytic Disorders and Treatments
- Genetic factors in colorectal cancer
- Platelet Disorders and Treatments
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2016-2025
Institute of Oncology Research
2013
Centro di Riferimento Oncologico
1996-2010
University of Bologna
2010
University of Siena
2010
University of Modena and Reggio Emilia
2010
Azienda Ospedaliero Universitaria Maggiore della Carita
2009
Ospedale Maggiore
2002-2009
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2002-2009
Zero to Three
2008
The pathogenesis of chronic lymphocytic leukemia (CLL), the most common in adults, is still largely unknown. full spectrum genetic lesions that are present CLL genome, and therefore number identity dysregulated cellular pathways, have not been identified. By combining next-generation sequencing copy analysis, we show here typical coding genome contains <20 clonally represented gene alterations/case, including predominantly nonsilent mutations, fewer aberrations. These analyses led to...
Abstract Purpose: Del17p13 predicts poor outcome and chemorefractoriness in chronic lymphocytic leukemia (CLL). Conversely, it is unknown whether TP53 mutations carry any prognostic value independent of del17p13. We tested the CLL. Experimental Design: The study was based on a consecutive series 308 DNA sequencing exons 2 to 10 del17p13 interphase fluorescence situ hybridization were done at CLL diagnosis. Study end points survival chemorefractoriness. Results: At diagnosis, (n = 32)...
Background: The gene encoding the DNA repair enzyme O6-methylguanine methyltransferase (MGMT) is transcriptionally silenced by promoter hypermethylation in several human cancers, including diffuse large B-cell lymphoma (B-DLCL). MGMT a favorable prognostic marker patients with brain tumors treated alkylating agents. Methods: In retrospective cohort study, we used methylation-specific polymerase chain reaction to analyze methylation status tumor of B-DLCL receiving cyclophosphamide as part...
The natural history of cancers associated with virus exposure is intriguing, since only a minority human tissues infected these viruses inevitably progress to cancer. However, the molecular reasons why infection controlled or instead progresses subsequent stages tumorigenesis are largely unknown. In this article, we provide first complete DNA methylomes double-stranded cancer that might important clues help us understand described process. Using bisulfite genomic sequencing multiple clones,...
Predictors of chronic lymphocytic leukaemia (CLL) transformation to Richter syndrome (RS) are not established and were investigated in 185 consecutive CLL cases. Actuarial incidence RS (n = 17; all diffuse large B-cell lymphomas) at 10 years was 16.2% (95% confidence interval: 8.0-24.4%). At diagnosis, prognosticators by univariate analysis IGHV homology >/=98% (P 0.006), IGHV4-39 usage < 0.001), del13q14 absence 0.004), expression CD38 0.001) ZAP70 size number lymph nodes, advanced Binet...
As the population ages, identification of preventive strategies able to delay cognitive and functional decline associated with aging represents a major challenge. To date, multidimensional approaches seem be effective in reducing or delaying onset age-related diseases. The multicentric randomized controlled trial IN-TeMPO (ItaliaN study Tailored Multidomain interventions Prevent community-dwelling Older adults, ClinicalTrials.gov ID NCT06248723), framed within World-Wide FINGERS network,...
A fraction of chronic lymphocytic leukaemia (CLL) cases carry highly homologous B-cell receptors (BCR), i.e. characterized by non-random combinations immunoglobulin heavy-chain variable (IGHV) genes and complementarity determining region-3 (HCDR3), often associated with a restricted selection IGVK/L light chains. Such 'stereotyped' BCR occur more frequently in CLL unmutated (UM) than mutated (M) IGHV genes. We analysed 1426 IG rearrangements (from 1398 cases) clustering driven HCDR3...
Antigen stimulation may be important for splenic marginal zone lymphoma pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases. Sixteen (12%) showed BCR; 7 86 (8%) retrieved databases also belonged to subsets. Three categories subsets were identified: i) "SMZL-specific subsets" (n=5), composed only 12 (9 HCV-from our series); ii) "Non-Hodgkin's lymphoma-like...
Human herpesvirus-8/Kaposi sarcoma-associated herpesvirus–positive primary effusion lymphoma (PEL) is a recently identified B-cell non-Hodgkin category characterized by liquid growth in the serous body cavities. Apart from viral infection, no genetic alteration known to be associated with PEL and recurrent cytogenetic abnormality has been these lymphomas. Yet consistent monoclonality of indicates that disease not solely virus-driven proliferation. Here we report high frequency mutations BCL6...
Non-Hodgkin lymphomas (NHL) represent a frequent complication of human immunodeficiency virus (HIV) infection. To elucidate HIV-NHL pathogenesis, we performed genome-wide DNA profiling based on single nucleotide polymorphism-based microarray comparative genomic hybridization in 57 HIV-lymphomas and, for comparison, 105 immunocompetent diffuse large B-cell (IC-DLBCL). Genomic complexity varied across subtypes. HIV-Burkitt lymphoma showed significantly lower number lesions than HIV-DLBCL (P =...