A5053291807- RNA Research and Splicing
- Herpesvirus Infections and Treatments
- Muscle Physiology and Disorders
- Viral Infections and Vectors
- Animal Virus Infections Studies
- RNA and protein synthesis mechanisms
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Cytomegalovirus and herpesvirus research
- Poxvirus research and outbreaks
- Immune Cell Function and Interaction
- HIV Research and Treatment
- Plant Virus Research Studies
- interferon and immune responses
- Zoonotic diseases and public health
- Viral Infections and Outbreaks Research
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- Viral Infections and Immunology Research
- Mosquito-borne diseases and control
- Genetic Associations and Epidemiology
- vaccines and immunoinformatics approaches
- Hepatitis C virus research
- T-cell and B-cell Immunology
- RNA regulation and disease
IRCCS Eugenio Medea
2016-2025
University of Milano-Bicocca
2024-2025
Centro San Giovanni di Dio Fatebenefratelli
2019-2023
Ethiopian Civil Service University
2023
Institute of Bioinformatics
2015
University of Turin
2011
Zero to Three
2011
Istituti di Ricovero e Cura a Carattere Scientifico
2003-2010
Center for Clinical Research (United States)
2006
Wadsworth Center
2006
Previous genome-wide scans of positive natural selection in humans have identified a number non-neutrally evolving genes that play important roles skin pigmentation, metabolism, or immune function. Recent studies also shown pattern local adaptation can be detected by identifying correlations between patterns allele frequencies and environmental variables. Despite these observations, the degree to which is primarily driven environments, role pathogens other ecological factors as selective...
The novel coronavirus severe acute respiratory syndrome 2 (SARS-CoV-2) that recently emerged in China is thought to have a bat origin, as its closest known relative (BatCoV RaTG13) was described previously horseshoe bats. We analyzed the selective events accompanied divergence of SARS-CoV-2 from BatCoV RaTG13. To this end, we applied population genetics-phylogenetics approach, which leverages within-population variation and an outgroup. Results indicated most sites viral open reading frames...
Duchenne muscular dystrophy is a lethal recessive disease characterized by widespread muscle damage throughout the body. This increases difficulty of cell or gene therapy based on direct injections into muscles. One way to circumvent this obstacle would be use circulating cells capable homing sites lesions. Here, we showed that stem antigen 1 (Sca-1), CD34 double-positive purified from tissues newborn mice are multipotent in vitro and can undergo both myogenic multimyeloid differentiation....
Many human genes have adapted to the constant threat of exposure infectious agents; according "hygiene hypothesis," lack parasites in modern settings results immune imbalances, augmenting susceptibility development autoimmune and allergic conditions. Here, by estimating number pathogen species/genera a specific geographic location (pathogen richness) for 52 populations analyzing 91 interleukin (IL)/IL receptor (IL genes), we show that helminths been major selective force on subset these...
Interferons (IFNs) are cytokines that play a key role in innate and adaptive immune responses. Despite the large number of immunological studies these molecules, relative contributions numerous IFNs to human survival remain largely unknown. Here, we evaluated extent which natural selection has targeted their receptors, provide insight into mechanisms govern host defense setting. We found some IFN-α subtypes, such as IFN-α6, IFN-α8, IFN-α13, IFN-α14, well type II IFN-γ, have evolved under...
Historically, allelic variations in blood group antigen (BGA) genes have been regarded as possible susceptibility factors for infectious diseases. Since host–pathogen interactions are major determinants evolution, BGAs can be thought of selection targets. In order to verify this hypothesis, we obtained an estimate pathogen richness geographic locations corresponding 52 populations distributed worldwide; after correction multiple tests and variables different from selective forces,...
Abstract TLR3 recognizes dsRNA and activates antiviral immune responses through the production of inflammatory cytokines type I IFNs. Genetic association studies have provided evidence concerning role a polymorphism in (rs3775291, Leu412Phe) viral infection susceptibility. We genotyped rs3775291 population Spanish HIV-1–exposed seronegative (HESN) individuals who remain HIV despite repeated exposure i.v. injection drug use (IDU-HESN individuals) as witnessed by their hepatitis C virus...
Members of the family Arenaviridae produce enveloped virions containing genomes consisting two or three single-stranded RNA segments totalling about 10.5 kb. Arenaviruses can infect mammals, including humans and other primates, snakes, fish. This is a summary International Committee on Taxonomy Viruses (ICTV) Report , which available at www.ictv.global/report/arenaviridae .
Arenaviridae is a family for ambisense RNA viruses with genomes of about 10.5 kb that infect mammals, snakes, and fish. The arenavirid genome consists two or three single-stranded segments encodes nucleoprotein (NP), glycoprotein (GP) large (L) protein containing RNA-directed polymerase (RdRP) domains; some arenavirids encode zinc-binding (Z). This summary the International Committee on Taxonomy Viruses (ICTV) report Arenaviridae, which available at www.ictv.global/report/arenaviridae.
The ongoing worldwide monkeypox outbreak is caused by viral lineages (globally referred to as hMPXV1) that are related but distinct from clade IIb MPXV viruses transmitted within Nigeria. Analysis of the genetic differences has indicated APOBEC-mediated editing might be responsible for unexpectedly high number mutations observed in hMPXV1 genomes. Here, using 1,624 publicly available sequences, we analyzed accrued between 2017 and emergence current predominant variant (B.1), well those have...
Recent evidence indicates that neural stem cell properties can be found among a mammalian skin-derived multipotent population. A major barrier in the further characterization of human progenitors is inability to isolate this population based on expression surface markers. Our work has been devoted purified cells are capable differentiation, presence or absence AC133 marker. The enriched AC133(+) express CD34 and Thy-1 antigens. These cultured growth medium containing epidermal factor (EGF)...
Human pre‐mRNAs contain a definite number of exons and several pseudoexons which are located within intronic regions. We applied computational approach to address the question how neglected in favor possibly identify sequence elements preventing pseudoexon splicing. A search for possible splicing silencers was carried out on selection that resembled terms splice site strength exon enhancer (ESE) representation; three motifs were retrieved through hexamer composition comparisons. One these...
Human ERAP1 and ERAP2 encode two endoplasmic reticulum aminopeptidases. These enzymes trim peptides to optimal size for loading onto major histocompatibility complex class I molecules shape the antigenic repertoire presented CD8+ T cells. Therefore, may be considered potential selection targets modulators of infection susceptibility. We resequenced genic regions in three HapMap populations. In both cases, we observed high levels nucleotide variation, an excess intermediate-frequency alleles,...
Middle East respiratory syndrome-related coronavirus (MERS-CoV) spreads to humans via zoonotic transmission from camels. MERS-CoV belongs lineage C of betacoronaviruses (betaCoVs), which also includes viruses isolated bats and hedgehogs. A large portion the betaCoV genome consists two open reading frames (ORF1a ORF1b) that are translated into polyproteins. These cleaved by viral proteases generate 16 nonstructural proteins (nsp1 nsp16) compose replication-transcription complex. We...
Humans possess a communication system based on spoken and written language. Other animals can learn vocalization by imitation, but this is not equivalent to human Many genes were described be implicated in language impairment (LI) developmental dyslexia (DD), their evolutionary history has been thoroughly analyzed. Herein we analyzed the evolution of ten involved DD LI. Results show that LI for mammals aves was comparable vocal-learner species non-learners. For lineage, several sites showing...