A5078781677- Multiple Sclerosis Research Studies
- Autism Spectrum Disorder Research
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Vitamin D Research Studies
- Polyomavirus and related diseases
- RNA regulation and disease
- Immunotherapy and Immune Responses
- Tryptophan and brain disorders
- Parkinson's Disease Mechanisms and Treatments
- Systemic Lupus Erythematosus Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cellular transport and secretion
- Virology and Viral Diseases
- Viral Infections and Immunology Research
- Viral-associated cancers and disorders
- Genetics, Aging, and Longevity in Model Organisms
- Chromosomal and Genetic Variations
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
- Full-Duplex Wireless Communications
- Genomic variations and chromosomal abnormalities
Don Carlo Gnocchi Foundation
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2000-2023
Kyushu University
2023
University of Milan
1999-2021
Piedmont University
2015
Fondazione Santa Lucia
2015
Department of Medical Sciences
2015
Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies
2015
Zero to Three
2013
International Flame Research Foundation
2013
Genomewide association studies of autoimmune diseases have mapped hundreds susceptibility regions in the genome. However, only for a few signals has causal gene been identified, and even fewer variant underlying mechanism defined. Coincident associations DNA variants affecting both risk disease quantitative immune variables provide an informative route to explore mechanisms drug-targetable pathways.Using case-control samples from Sardinia, Italy, we performed genomewide study multiple...
Blood-based biomarkers are needed to be used as easy, reproducible, and non-invasive tools for the diagnosis prognosis of chronic neurodegenerative disorders including Parkinson's Disease (PD). In PD, aggregated toxic forms α-Synuclein (α-Syn) accumulate within neurons in brain cause neurodegeneration; α-Syn interaction with SNARE proteins also results synaptic disfunction. We isolated neural derived extravesicles (NDEs) from peripheral blood 32 PD patients 40 healthy controls (HC) measured...
Approximately 15% of multiple sclerosis (MS) patients develop a progressive form disease from onset; this condition (primary progressive-PP) MS is difficult to diagnose and treat, associated with poor prognosis. Extracellular vesicles (EVs) brain origin isolated blood their protein cargoes could function as biomarker pathological conditions. We verified whether MBP MOG content in oligodendrocytes-derived EVs (ODEVs) be biomarkers help the differential diagnosis clinical phenotypes. A total...
To explore the mechanisms underlying suggested role of vitamin D/vitamin D receptor (VDR) complex in pathogenesis obesity we performed genetic and immunologic analyses obese non-obese Saudi individuals without other concomitant chronic diseases. Genomic DNA was genotyped for gene single nucleotide polymorphisms (SNPs) VDR by allelic discrimination 402 (body mass index –BMI≥30 kg/m2) 489 (BMI<30 Saudis. Q-PCR were using an ABI Prism 7000 Sequence Detection System. The inflammosome pathway...
Synaptosomal-associated protein of 25 kDa (SNAP-25) is involved in different neuropsychiatric disorders, including schizophrenia and attention-deficit/hyperactivity disorder. Consistently, SNAP-25 polymorphisms humans are associated with hyperactivity and/or low cognitive scores. We analysed five gene (rs363050, rs363039, rs363043, rs3746544 rs1051312) 46 autistic children trying to correlate them Childhood Autism Rating Scale electroencephalogram (EEG) abnormalities. The functional effects...
Humans possess a communication system based on spoken and written language. Other animals can learn vocalization by imitation, but this is not equivalent to human Many genes were described be implicated in language impairment (LI) developmental dyslexia (DD), their evolutionary history has been thoroughly analyzed. Herein we analyzed the evolution of ten involved DD LI. Results show that LI for mammals aves was comparable vocal-learner species non-learners. For lineage, several sites showing...
The early differential diagnosis of Parkinson's disease (PD) and atypical Parkinsonian syndromes (APS), including corticobasal degeneration (CBD) progressive supranuclear palsy (PSP), is challenging because an overlap clinical features the lack reliable biomarkers. Neural-derived extracellular vesicles (NDEVs) isolated from blood provide a window into brain's biochemistry may assist in distinguishing between PD APS. We verified case-control study whether oligomeric α-Synuclein Tau aggregates...
Abstract Background The incidence of Alzheimer's disease (AD)—the most frequent cause dementia—is expected to increase as life expectancies rise across the globe. While sex-based differences in AD have previously been described, there remain uncertainties regarding any association between sex and disease-associated molecular mechanisms. Studying sex-specific expression profiles regulatory factors such microRNAs (miRNAs) could contribute more accurate diagnosis treatment. Methods A systematic...
ALS is a heterogeneous disease that not well understood. Epigenetic rearrangements are important in complex disorders including motor neuron diseases. The aim of this study was to determine whether whole-blood DNA methylation (DNA MET %) potential modifier age at onset ALS. % measured as incorporation [(3)H]dCTP following HpaII cut 96 patients and 87 controls, comprising: early-onset (< 55 years age) late-onset (> 74 age). Methionine (Met) homocysteine (Hcy) plasma levels were assessed by...
The etiopathology of multiple sclerosis (MS) is believed to include genetic and environmental factors. Human leukocyte antigen (HLA) alleles, in particular, are associated with disease susceptibility, whereas Epstein Barr Virus (EBV) infection has long been suspected play a role pathogenesis. aim the present study evaluate correlations between HLA alleles EBV MS. viral load (VL) serum anti-EBV antibody titers were evaluated EBV-seropositive MS patients (N = 117) age- sex-matched healthy...
We analyzed the Epstein-Barr nuclear antigen 2 (EBNA2) gene, which contains most variable region of viral genome, in persons with multiple sclerosis (MS) and control subjects to verify whether virus genetic variants are involved disease development.A seminested PCR approach Sanger sequencing were used analyze EBNA2 53 patients 38 matched healthy donors (HDs). High-throughput by Illumina MiSeq was also applied a subgroup (17 17 HDs). Patients underwent gadolinium-enhanced MRI human leucocyte...
ABSTRACT Physical exercise has been associated with healthier aging trajectories, potentially preventing or mitigating age‐related declines. This occurs through a complex, yet poorly characterized network of multi‐organ interactions involving mitochondrial, inflammatory, and cell death/survival pathways. Here, we comprehensively evaluated the 12‐week VIVIFRAIL multicomponent protocol in physically frail ( n = 16, mean age 81.4 ± 5.6) robust 50, mean‐age 73.6 4.7) old individuals. Before (T0)...
<b><i>Background:</i></b> Copolymer 1 (Cop-1) is a random synthetic amino acid copolymer, effective in the treatment of relapsing-remitting form MS (RRMS). In vitro and vivo studies suggest that mechanism Cop-1 involves its binding to major histocompatibility complex class II molecules as an initial step. <b><i>Objective:</i></b> To assess possible relationship between human leukocyte antigen (HLA) alleles response therapy. <b><i>Methods:</i></b> Eighty-three patients with RRMS, 44 treated...
Two brothers had late-onset progressive ataxia, cerebellar atrophy, and hypergonadotropic hypogonadism associated with coenzyme Q10 (CoQ10) deficiency in skeletal muscle. Both patients improved on high-dose CoQ10 supplementation, stressing the importance of differential diagnosis even when onset is late.