A5000752471- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
- Autoimmune and Inflammatory Disorders Research
- Cerebral Palsy and Movement Disorders
- Peripheral Neuropathies and Disorders
- Systemic Sclerosis and Related Diseases
- Effects of Vibration on Health
- Cytokine Signaling Pathways and Interactions
- Botulinum Toxin and Related Neurological Disorders
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Mycobacterium research and diagnosis
- Acute Lymphoblastic Leukemia research
- Balance, Gait, and Falls Prevention
- Muscle activation and electromyography studies
- Hereditary Neurological Disorders
- Long-Term Effects of COVID-19
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Fungal Plant Pathogen Control
- T-cell and B-cell Immunology
- Pharmacological Effects of Natural Compounds
- Vestibular and auditory disorders
- Immunotherapy and Immune Responses
- Transcranial Magnetic Stimulation Studies
University of Cagliari
2015-2024
ATS Sardegna (Italy)
2017-2024
Regione Puglia
2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2017
Vita-Salute San Raffaele University
2017
Ospedale degli Infermi
2015-2016
Associazione Italiana Sclerosi Multipla
2013
Genomewide association studies of autoimmune diseases have mapped hundreds susceptibility regions in the genome. However, only for a few signals has causal gene been identified, and even fewer variant underlying mechanism defined. Coincident associations DNA variants affecting both risk disease quantitative immune variables provide an informative route to explore mechanisms drug-targetable pathways.Using case-control samples from Sardinia, Italy, we performed genomewide study multiple...
Abstract Background ChatGPT is an open-source natural language processing software that replies to users’ queries. We conducted a cross-sectional study assess people living with Multiple Sclerosis’ (PwMS) preferences, satisfaction, and empathy toward two alternate responses four frequently-asked questions, one authored by group of neurologists, the other ChatGPT. Methods An online form was sent through digital communication platforms. PwMS were blind author each response asked express their...
To investigate the metabolomic profiles of patients with multiple sclerosis (MS) and to define metabolic pathways potentially related MS pathogenesis.Plasma samples from 73 (therapy-free for at least 90 days) 88 healthy controls (HC) were analyzed by (1)H-NMR spectroscopy. Data analysis was conducted principal components followed a supervised (orthogonal partial squares discriminant [OPLS-DA]). The metabolites identified quantified using Chenomx software, receiver operating characteristic...
Together with the wide range of possible benefits for rehabilitation/training people multiple sclerosis (pwMS) and other neurologic conditions, exposure to immersive virtual reality (VR) has often been associated unpleasant symptoms, such as transient dizziness, headache, nausea, disorientation impaired postural control (i.e., cybersickness). Since these symptoms can significantly impact safety tolerability treatment, it appears important correctly estimate their presence magnitude. Given...
Sardinia is a known high-risk area for multiple sclerosis (MS), but no data south-western (SWS) are available. SWS has genetically homogeneous population, apart from St Peter Island, and represents peculiar environment related to the industrial, mineralogical military economy.To estimate prevalence incidence evaluate temporal trends geographical distribution of MS in SWS.MS was evaluated on 31 December 2007 crude mean annual rate defined between 2003 2007. Temporal trend assessed using...
Multiple sclerosis (MS) has a major impact on the physical, psychological and social life of patients their families. The aim this study was to evaluate different perceptions caregivers about management MS, particularly same items, gather information ameliorate care patients.We evaluated what MS perceive as unmet needs compared patients' opinions with caregivers' using multidimensional questionnaire. questionnaire specifically designed for study, taking into account aspects global perceived...
Background: Rituximab, an anti-CD20 monoclonal antibody leading to B lymphocyte depletion, is increasingly used as off-label treatment option for multiple sclerosis (MS). Objective: To investigate the effectiveness and safety of rituximab in relapsing–remitting (RR) progressive MS. Methods: This a multicenter, retrospective study on consecutive MS patients treated with 22 Italian 1 Swiss centers. Relapse rate, time first relapse, Expanded Disability Status Scale (EDSS) progression, incidence...
Abstract Objective To evaluate whether multiple sessions of transcranial direct current stimulation (tDCS) applied to the primary motor (M1) cortex paired with aerobic exercise can improve walking functions in sclerosis (MS). Methods MS participants were recruited for a double‐blind, parallel‐arm, randomized, sham‐controlled trial and assigned 10 (5 d/wk 2 weeks) either active or sham tDCS unloaded cycling 20 minutes. Stimulation was administered over left M1 (2.5 mA; anode C3/cathode FP2)....
The principal biomarker of neurodegeneration in multiple sclerosis (MS) is believed to be brain volume, which associated with cognitive functions and retinal nerve fibre layer (RNFL). A cross-sectional longitudinal assessment the relationship between RNFL, volume. At baseline, relapsing patients healthy controls underwent 1.5 T MRI estimate normalized volume (NBV), grey (NGV), white (NWV) peripheral (pNGV) matter. Cognitive were evaluated by BICAMS, RNFL Spectral-Domain OCT. Patients...
Background and objective: A critical aspect of multiple sclerosis (MS) treatments is understanding the effect disease-modifying drugs (DMDs) on long-term risk disability whether related to at start treatment. Methods: We performed an observational study 3060 MS patients. The therapy progression Expanded Disability Status Scale (EDSS) 3.0 6.0 from onset was analysed in treated vs untreated (UTP) patients using Cox regression analysis adjusted for propensity score immortal time bias. Results:...
Frequently diagnosed in young adulthood, multiple sclerosis (MS) and several MS-related factors can influence patients' unemployment status negatively affect work productivity daily functioning.We examined MS employment evaluated clinical features influencing it. Furthermore, we investigated burdens due to visible invisible symptoms through their worsening functioning.The study included outpatients affected by according the 2010 McDonald criteria. The co-occurrence of (fatigue, depression...
Walking impairments are a debilitating feature of multiple sclerosis (MS) because the direct interference with daily activity. The management motor symptoms in those MS remains therapeutic challenge. Transcranial current stimulation (tDCS) is type non-invasive brain that emerging as promising rehabilitative tool but requires further characterization to determine its optimal use. In this randomized, sham-controlled proof-of-concept study, we tested immediate effects single tDCS session on...
Introduction Genetic predisposition to multiple sclerosis (MS) in Sardinia (Italy) has been associated with five DRB1*-DQB1* haplotypes of the human leukocyte antigen (HLA). Given complexity these associations, an in-depth re-analysis was performed specific aims confirming haplotype associations; establishing independence haplotypes; and assessing patients' genotypic risk developing MS. Methods Results A transmission disequilibrium test (TDT) 943 trio families, confirmed a higher than...
Synaptic transmission and plasticity mediated by NMDA receptors (NMDARs) could modulate the severity of multiple sclerosis (MS). Here role NMDARs in MS was first explored 691 subjects carrying specific allelic variants NR1 subunit gene or NR2B this glutamate receptor. The analysis replicated for significant SNPs an independent sample 1548 subjects. C allele rs4880213 found to be associated with reduced NMDAR-mediated cortical excitability, increased probability having more disability than...
Background: Mycobacterium avium subspecies paratuberculosis (MAP) is an infectious factor recently found in association with multiple sclerosis (MS) Sardinia. Objectives: The objectives of this study were to confirm and evaluate its role clinical features. Methods: A total 436 patients 264 healthy controls (HCs) included. We examined the blood each individual for MAPDNA MAP2694 antibodies using IS900-specific PCR ELISA, respectively. Differences MAP presence between MS group HCs evaluated....
Objectives Multiple sclerosis (MS) is a chronic disease that mainly affects young people. Patients with MS experience several emotional responses to changed perceptions of themselves and manage this situation in ways focused on controlling the overall burden disease. This present study aimed evaluate differences between patients healthy controls (HCs) coping styles, identifying clinical features influence adaptive responses. Methods MS, according McDonald 2010 criteria, HCs were recruited....