Maristella Steri
A5010278387- Genetic Associations and Epidemiology
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- Folate and B Vitamins Research
- Multiple Sclerosis Research Studies
- Hemoglobinopathies and Related Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Iron Metabolism and Disorders
- Atherosclerosis and Cardiovascular Diseases
- Immunotherapy and Immune Responses
- Genetic Syndromes and Imprinting
- Diabetes and associated disorders
- Blood properties and coagulation
- Peripheral Neuropathies and Disorders
- Cytokine Signaling Pathways and Interactions
- Forensic and Genetic Research
- Thyroid Disorders and Treatments
- Genomics and Rare Diseases
- Growth Hormone and Insulin-like Growth Factors
- Cancer Immunotherapy and Biomarkers
- Hypothalamic control of reproductive hormones
National Research Council
2016-2025
Institute of Genetic and Biomedical Research
2016-2025
National Academies of Sciences, Engineering, and Medicine
2021-2024
University of Cagliari
2010-2022
The Research Institute on Judicial Systems
2018
University of Cambridge
2012
Genomewide association studies of autoimmune diseases have mapped hundreds susceptibility regions in the genome. However, only for a few signals has causal gene been identified, and even fewer variant underlying mechanism defined. Coincident associations DNA variants affecting both risk disease quantitative immune variables provide an informative route to explore mechanisms drug-targetable pathways.Using case-control samples from Sardinia, Italy, we performed genomewide study multiple...
Abstract Some people remain healthier throughout life than others but the underlying reasons are poorly understood. Here we hypothesize this advantage is attributable in part to optimal immune resilience (IR), defined as capacity preserve and/or rapidly restore functions that promote disease resistance (immunocompetence) and control inflammation infectious diseases well other causes of inflammatory stress. We gauge IR levels with two distinct peripheral blood metrics quantify balance between...
Identifying the genes that influence levels of pro-inflammatory molecules can help to elucidate mechanisms underlying this process. We first conducted a two-stage genome-wide association scan (GWAS) for key inflammatory biomarkers Interleukin-6 (IL-6), general measure inflammation erythrocyte sedimentation rate (ESR), monocyte chemotactic protein-1 (MCP-1), and high-sensitivity C-reactive protein (hsCRP) in large cohort individuals from founder population Sardinia. By analysing 731,213...
Objectives Vaccination against COVID-19 is highly recommended to patients affected by multiple sclerosis (MS); however, the impact of MS disease-modifying therapies (DMTs) on immune response following vaccination has been only partially investigated. Here, we aimed elucidate effect DMTs humoral mRNA-based anti-SARS-CoV-2 vaccines in patients. Methods We obtained sera from 912 Sardinian and 63 healthy controls 30 days after second dose BNT162b2 vaccine tested them for SARS-CoV-2 using...
The risk of severe coronavirus disease 2019 (COVID-19) varies significantly among persons similar age and is higher in males. Age-independent, sex-biased differences susceptibility to COVID-19 may be ascribable deficits a sexually dimorphic protective attribute that we termed immunologic resilience (IR).
The relationship of kidney size to ageing, function and disease risk factors is not fully understood.Ultrasound length parenchymal volume were determined from a population-based sample 3972 Sardinians (age range 18-100 years). We then identified the subset 2256 'healthy' subjects define age- sex-specific reference ranges (2.5-97.5 percentile) volume. Logistic regression (accounting for family clustering) was used identify clinical characteristics associated with abnormally large kidneys or...
In systemic lupus erythematosus (SLE), perturbed immunoregulation underpins a pathogenic imbalance between regulatory and effector CD4+ T-cell activity. However, to date, the characterisation of T cell (Treg) compartment in SLE has yielded conflicting results. Here we show that patients have an increased frequency CD4+FOXP3+ cells circulation owing specific expansion thymically-derived FOXP3+HELIOS+ Tregs with demethylated FOXP3 Treg-specific region. We found Treg was strongly associated...