A5101496354- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- IL-33, ST2, and ILC Pathways
- CAR-T cell therapy research
- Immune cells in cancer
- Reproductive tract infections research
- Reproductive System and Pregnancy
- Immune Response and Inflammation
- Eosinophilic Esophagitis
- RNA modifications and cancer
- Immune responses and vaccinations
- Genital Health and Disease
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cell death mechanisms and regulation
- NF-κB Signaling Pathways
- Cervical Cancer and HPV Research
- Chemokine receptors and signaling
- RNA Interference and Gene Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- COVID-19 Clinical Research Studies
The University of Texas Health Science Center at San Antonio
2015-2024
South Texas Veterans Health Care System
2021-2024
Fujian Provincial People's Hospital
2022
The University of Texas at San Antonio
2020-2021
The University of Texas Health Science Center at Houston
2021
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2021
Wenzhou Medical University
2021
Central South University
2018-2020
Audie L. Murphy Memorial VA Hospital
2017-2018
Second Xiangya Hospital of Central South University
2018
The innate immune response is essential for controlling West Nile virus (WNV) infection but how this propagated and regulates adaptive immunity in vivo are not defined. Herein, we show that IPS-1, the central adaptor protein to RIG-I-like receptor (RLR) signaling, triggering of effective development regulation against pathogenic WNV. IPS-1−/− mice exhibited increased susceptibility WNV marked by enhanced viral replication dissemination with early entry into CNS. Infection cultured...
The RNaseIII enzyme Dicer is required for mature microRNA production. Although extensive investigation has been carried out to determine the role of Dicer/miRNAs in immune system, their function CD8 + T cells not examined. We deleted polyclonal and TCR transgenic using either tat-cre or distal lck promoter, which drives cre expression after stage positive selection. Following antigenic challenge by a pathogen infection vivo, Dicer-deleted failed accumulate at usual peak response....
Exhausted-like CD8 + resident memory T cells in the lung limit immune activation–driven fibrosis.
Lower respiratory viral infections, such as influenza virus and severe acute syndrome coronavirus 2 often cause pneumonia in aged individuals. Here, we report that leads to chronic nonresolving lung pathology exacerbated accumulation of CD8+ tissue-resident memory T cells (TRM) the tract hosts. TRM cell relies on elevated TGF-β present tissues. Further, show isolated from lungs lack a subpopulation characterized by expression molecules involved TCR signaling effector function. Consequently,...
Recent studies have defined a novel population of PD-1+ TCF-1+ stem-like CD8 T cells in chronic infections and cancer. These quiescent reside lymphoid tissues, are critical for maintaining the cell response under conditions persistent antigen, provide proliferative burst after PD-1 blockade. Here we examined role TGF-β regulating differentiation virus-specific during LCMV infection mice. We found that signaling was not essential generation but state quiescence these cells. regulated unique...
Apoptosis-related genes play important roles in thymocyte maturation. We show that cellular FLICE-like inhibitory protein (c-FLIP), a procaspase-8-like apoptotic regulator, plays an essential role the efficient development of mature T lymphocytes. Mice conditionally lacking c-FLIP lymphocytes display severe defects cells, as indicated by dramatically reduced number CD4+ and CD8+ cells spleen lymph nodes mutant mice. The impaired lymphocyte maturation conditional knockout mice occurs at...
In addition to Foxp3+ CD4+ regulatory T cells (CD4+ reg cells), Foxp3− CD8+ (CD8+ cells) are critical maintain immune tolerance. However, the molecular programs that specifically control but not largely unknown. Here, we demonstrate simultaneous disruption of both TGF-β receptor and transcription factor Eomesodermin (Eomes) in results lethal autoimmunity due a specific defect cells. Further, signal maintains identity, while Eomes controls follicular location Both coordinate promote...
The long-term maintenance of memory T cells is essential for successful vaccines. Both the quantity and quality T-cell population must be maintained. signals that control remain incompletely identified. Here we used two genetic models to show continuous transforming growth factor-β signaling antigen-specific required differentiation CD8(+) cells. In addition, both infection-induced microbiota-induced inflammation impact phenotypic functional identity
Chlamydia has been detected in the gastrointestinal tracts of humans and animals. We now report that muridarum is able to induce robust transmucosal protection mice. C. colonization tract correlated with both a shortened course genital infection stronger against subsequent challenge infection. Mice preinoculated intragastrically became highly resistant tract, resulting prevention pathology upper tract. The was rapidly induced, durable, dependent on major histocompatibility complex (MHC)...
Tissue-resident memory T (TRM) cells, a population of noncirculating are one the essential components immunological in both mouse and human. Although CD69+CD103+ TRM cells represent major cell barrier tissues including mucosal surface skin, CD69+CD103- dominate most nonbarrier tissues, such as kidney. TGF-β is required for differentiation tissues. However, developmental control remains largely unknown involvement signaling less clear. In this study we demonstrated that promoted formation...
The risk of severe coronavirus disease 2019 (COVID-19) varies significantly among persons similar age and is higher in males. Age-independent, sex-biased differences susceptibility to COVID-19 may be ascribable deficits a sexually dimorphic protective attribute that we termed immunologic resilience (IR).
The oral mucosa is a frontline for microbial exposure and juxtaposes several unique tissues mechanical structures. Based on parabiotic surgery of mice receiving systemic viral infections or co-housing with microbially diverse pet shop mice, we report that the harbors CD8+ CD103+ resident memory T cells (TRM), which locally survey without recirculating. Oral antigen re-encounter during effector phase immune responses potentiated TRM establishment within tongue, gums, palate, cheek. Upon...
Chlamydia muridarum is known to colonize in the gastrointestinal tract for long periods of time, which has been hypothesized serve as a reservoir spreading genital tract. To test this hypothesis, luciferase-expressing C. was used establish long-lasting infection mouse following either intragastric or intrarectal inoculations. In vivo imaging revealed significant bioluminescent signals mainly abdominal area throughout experiments. Ex localized tract, confirmed by monitoring organisms...
Stem-like CD8+ T cells sustain the antigen-specific cell response during chronic antigen exposure. However, signals that control maintenance and differentiation of these are largely unknown. Here, we demonstrated TGF-β was essential for optimal inhibited their into migratory effectors viral infection. Mechanistically, stem-like carried a unique expression pattern α4 integrins (i.e., α4β1hi α4β7lo) controlled by TGF-β. In absence signaling, greatly enhanced migration-related markers,...
TGF-β signaling is necessary for CD8+ T cell differentiation into tissue resident memory cells (TRM). Although higher frequency of TRM in the tumor microenvironment associated with better prognosis, TGF-β-blockade typically improves rather than worsens outcomes. Here we show that a mouse melanoma model, tumor-draining lymph nodes (TDLN) tumors themselves, stem-like differentiate TRMs and antigen dependent manner. Following vaccination against melanoma-specific epitope, most tumour-specific...
Abstract The antiapoptotic protein Bcl-xL is induced in activated T lymphocytes upon costimulation through CD28, 4-1BB, and OX40. also highly enriched memory lymphocytes. Based on this body of evidence, it was thought that plays an essential role the generation effector We report mice with a conditional deletion Bcl-x develop normal CD8+ cell response to Listeria monocytogenes infection. Furthermore, knockout exhibit T-dependent humoral immune responses. These results indicate dispensable...