A5100675159- Cerebrovascular and Carotid Artery Diseases
- DNA Repair Mechanisms
- Cancer Immunotherapy and Biomarkers
- PARP inhibition in cancer therapy
- Autophagy in Disease and Therapy
- Spine and Intervertebral Disc Pathology
- Neuroblastoma Research and Treatments
- Telomeres, Telomerase, and Senescence
- Acne and Rosacea Treatments and Effects
- Dermatology and Skin Diseases
- Plasma Applications and Diagnostics
- Curcumin's Biomedical Applications
- Sexuality, Behavior, and Technology
- Healthcare and Venom Research
- Polyamine Metabolism and Applications
- Pelvic and Acetabular Injuries
- Wound Healing and Treatments
- Head and Neck Cancer Studies
- Prenatal Screening and Diagnostics
- Contact Dermatitis and Allergies
- Hemostasis and retained surgical items
- Cellular Mechanics and Interactions
- Angiogenesis and VEGF in Cancer
- Cholinesterase and Neurodegenerative Diseases
- Advanced Radiotherapy Techniques
University College London
2022-2025
Lunenfeld-Tanenbaum Research Institute
2024-2025
Sinai Health System
2024-2025
Northwest University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Affiliated Hospital of Southwest Medical University
2024
Hebei Medical University
2023
Xiangya Hospital Central South University
2021-2023
Central South University
2021-2023
Chongqing Medical University
2019-2023
Heart sound diagnosis and classification play an essential role in detecting cardiovascular disorders, especially when the remote becomes standard clinical practice. Most of current work is designed for single category based heard tasks. To further extend landscape automatic heart landscape, this proposes a deep multilabel learning model that can automatically annotate recordings with labels from different label groups, including murmur's timing, pitch, grading, quality, shape. Our...
Background Insulin resistance is associated with atrial remodeling as well fibrillation (AF). However, there was limited evidence on the relationship of triglyceride-glucose index (TyG) index, a simple, valuable marker insulin resistance, AF. Thus, we aimed to investigate association between TyG and AF among hospitalized patients. Methods A retrospective observational study conducted in Daping Hospital, which included 356 patients from Department Cardiology. Clinical biochemical parameters...
Abstract The progressive decline of physiological function and the increased risk age-related diseases challenge healthy aging. Multiple anti-aging manipulations, such as senolytics, have proven beneficial for health; however, biomarkers that label in vivo senescence at systemic levels are lacking, thus hindering applications. In this study, we generate a Glb1 +/m ‒Glb1-2A-mCherry (GAC) reporter allele gene locus, which encodes lysosomal β-galactosidase—an enzyme elevated tissues old mice. A...
Aims/Purpose: Alzheimer's disease (AD) is the most prevalent form of dementia and remains a pressing concern in our society with an ageing population. Increasing evidences suggest link between brain damage retinal ganglion cell (RGC) loss opening new paradigm to diagnose this condition using eye as window brain. Curcumin natural polyphenol neuroprotective properties but low bioavailability preventing its use potential treatment AD. The goal research was assess novel formulation curcumin...
Aims/Purpose: Alzheimer's disease (AD) is the most prevalent form of dementia and remains a pressing concern in our society with an ageing population. Increasing evidences suggest link between brain damage retinal ganglion cell (RGC) loss opening new paradigm to diagnose this condition using eye as window brain. Curcumin natural polyphenol neuroprotective properties but low bioavailability preventing its use potential treatment AD. The goal research was assess novel formulation curcumin...
TGF-β signaling is necessary for CD8+ T cell differentiation into tissue resident memory cells (TRM). Although higher frequency of TRM in the tumor microenvironment associated with better prognosis, TGF-β-blockade typically improves rather than worsens outcomes. Here we show that a mouse melanoma model, tumor-draining lymph nodes (TDLN) tumors themselves, stem-like differentiate TRMs and antigen dependent manner. Following vaccination against melanoma-specific epitope, most tumour-specific...
To build an automatic pathological diagnosis model to assess the lymph node metastasis status of head and neck squamous cell carcinoma (HNSCC) based on deep learning algorithms.A retrospective study.A diagnostic integrating two-step networks was trained analyze in 85 images HNSCC nodes. The tested a test set 21 with 29 without metastasis. All were scanned from sections stained hematoxylin-eosin (HE).In set, overall accuracy, sensitivity, specificity reached 86%, 100%, 75.9%, respectively.Our...
Acute cerebrovascular accidents, long-term hypoperfusion, and/or remote neuronal degeneration may lead to structural alterations in patients with moyamoya disease (MMD). This study sought comprehensively investigate the distribution characteristics of subcortical gray matter volume and their correlations angiographic changes intracranial artery MMD.One hundred forty-two MMD 142 age- sex-matched healthy controls underwent 3-dimensional high-resolution magnetic resonance imaging. Volumes...
Abstract The stem cell theory of aging dictates that a decline in the number and/or function cells causes tissue degeneration and aging; however, it still lacks unequivocal experimental support. Here, using lineage tracing single-cell transcriptomics, we identify population CD133 + bone marrow-derived endothelial-like (ELCs) as potential endothelial progenitor cells, which contribute to tubular structures vitro neovascularization vivo. We demonstrate supplementation with wild-type young ELCs...
Objective This study intended to assess the efficacy of colchicine for prevention post-operative atrial fibrillation (AF). Background Post-operative AF is a common complication surgery operations. Inflammation plays crucial role in pathogenesis AF. Colchicine, potent anti-inflammatory drug, may have mitigating incidence Methods We searched Cochrane Library, Web Science, PubMed, China National Knowledge Infrastructure (CNKI), Database Chinese sci-tech periodicals (COVIP), and Wanfang...
Myocardial ischemia may induce myocardial fibrosis, a condition that progressively leads to ventricular remodeling, heightening the risk of heart failure. The timely detection fibrosis is crucial for intervention and improved outcomes. 68 Ga-FAPI-04 PET/CT shows promise in assessing fibroblast activation patients with early infarction characterized by prolonged ischemia. However, there notable absence data regarding short-term ischemia, such as those experiencing unstable angina (UA). In...
Cells are subjected to dynamic mechanical environments which impart forces and induce cellular responses. In age-related conditions like pulmonary fibrosis, there is both an increase in tissue stiffness accumulation of senescent cells. While cells produce a senescence-associated secretory phenotype (SASP), the impact physical stimuli on senescence SASP not well understood. Here, we show that tension, modeled using cell culture substrate rigidity, influences markers SA-β-gal phenotypes....
In this letter, ignited by a kilohertz atmospheric-pressure dielectric-barrier discharge (APDBD), the stable and uniform argon radio-frequency (rf) APDBDs are generated with lower rf ignition voltages compared to conventional without aid of filamentary discharges. The experimental studies on mechanisms dual-frequency APDBD method indicate that it is filaments extending from electrode region provide seed electrons for at applied voltages. A 12-mm-long plasma jet obtained using coaxial-type generator.
Abstract Cutaneous wound healing, an integral part for protection of skin barrier, is a complex biological process and intimately associated with keratinocyte migration. However, mechanisms regulating migration in the cutaneous repair remain largely unknown. Here, we found that N-acetyltransferase 10 (NAT10) essential vivo healing model—a significant delay Nat10 haploinsufficient mice remarkable inhibition by NAT10 knockdown vitro model. We further demonstrate loss expression attenuates...
The association between the degree of plaque enhancement and ischemic brain stroke recurrence remains unclear. We aimed to establish models predict recurrence.Seventy-eight participants with acute due intracranial arterial stenosis were recruited divided into high (HE) non-HE groups. relationship imaging characteristics (degree stenosis, minimal lumen area, intraplaque hemorrhage, burden) contrast was analyzed. Inflammatory cytokine expression examined by flow cytometry. Independent...
We explored the feasibility of app-based HIV testing services (AHTS) among men who have sex with (MSM) according to perspectives service providers. Twenty-one current or previous AHTS providers participated in a semi-structured interview which facilitators and barriers AHTS. Ten participants originating from Center for Disease Control Prevention (CDC) 11 non-governmental organization (NGO) Shijiazhuang, China took part this study. Interviews was transcribed verbatim, socioecological model...
Radio‐frequency (RF), atmospheric‐pressure glow discharge (APGD) plasmas with bare metallic electrodes have shown their promising prospects in different fields. In this paper, based on the induced gas approach, characteristics of RF, APGD using helium/oxygen mixture as plasma working‐gas are presented. The bio‐medical effects helium RF jet acting gfp DNA and E. coli also reported. Studies concerning lethal sub‐lethal APGDs molecular cell levels, which related operation conditions necessary...