A5027670252- Curcumin's Biomedical Applications
- Alzheimer's disease research and treatments
- Glaucoma and retinal disorders
- Sirtuins and Resveratrol in Medicine
- Retinal and Optic Conditions
- Cholinesterase and Neurodegenerative Diseases
- Retinopathy of Prematurity Studies
- Biochemical effects in animals
- Herpesvirus Infections and Treatments
- Retinal Development and Disorders
- Neurological Disorders and Treatments
- Retinoids in leukemia and cellular processes
- Nerve injury and regeneration
- Nicotinic Acetylcholine Receptors Study
- Toxin Mechanisms and Immunotoxins
- Calcium signaling and nucleotide metabolism
- Bioactive natural compounds
- RNA Interference and Gene Delivery
- Retinal Diseases and Treatments
- melanin and skin pigmentation
- Multiple Sclerosis Research Studies
- Ocular Diseases and Behçet’s Syndrome
- Biochemical Acid Research Studies
- Retinal and Macular Surgery
- Viral Infections and Outbreaks Research
University College London
2017-2025
John Radcliffe Hospital
2025
University of Oxford
2025
Hôpital Ophtalmique Jules-Gonin
2020-2024
University of Lausanne
2020-2024
Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5dione) is a polyphenol extracted from turmeric that has long been advocated for the treatment of variety conditions including neurodegenerative and inflammatory disorders. Despite this promise, clinical use curcumin limited by poor solubility low bioavailability molecule. In article, we describe novel nanocarrier formulation comprising Pluronic-F127 stabilised D-α-Tocopherol polyethene glycol 1000 succinate nanoparticles, which...
Purpose: Resveratrol is a natural polyphenol which has very low bioavailability but whose antioxidant, anti-inflammatory and anti-apoptotic properties may have therapeutic potential for the treatment of neurodegenerative diseases such as multiple sclerosis (MS). Previously, we reported oral administration resveratrol nanoparticles (RNs) elicited neuroprotective effect in an experimental autoimmune encephalomyelitis (EAE) mouse model MS, at significantly lower doses than unconjugated (RSV)...
Abstract Optic neuropathy is a major cause of irreversible blindness worldwide, and no effective treatment currently available. Secondary degeneration believed to be the contributor retinal ganglion cell (RGC) death, endpoint optic neuropathy. Partial nerve transection (pONT) an established model Although mechanisms primary secondary have been delineated in this model, until now how influenced by therapy not well-understood. In article, we describe clinically translatable topical,...
Aims/Purpose: Alzheimer's disease (AD) is the most prevalent form of dementia and remains a pressing concern in our society with an ageing population. Increasing evidences suggest link between brain damage retinal ganglion cell (RGC) loss opening new paradigm to diagnose this condition using eye as window brain. Curcumin natural polyphenol neuroprotective properties but low bioavailability preventing its use potential treatment AD. The goal research was assess novel formulation curcumin...
Aims/Purpose: Alzheimer's disease (AD) is the most prevalent form of dementia and remains a pressing concern in our society with an ageing population. Increasing evidences suggest link between brain damage retinal ganglion cell (RGC) loss opening new paradigm to diagnose this condition using eye as window brain. Curcumin natural polyphenol neuroprotective properties but low bioavailability preventing its use potential treatment AD. The goal research was assess novel formulation curcumin...
Introduction: The disease process of glaucoma is thought to begin up 20 years before a diagnosis can be made. While its current treatment paradigm seeks reduce the rate progression through reducing intraocular pressure, these interventions are limited effectiveness and typically made late. Together, this highlights an unmet clinical need for development novel techniques facilitate early emergence new paradigms. This review provides summary recent developments in glaucoma, including updates...
Identifying disease-specific patterns of retinal cell loss in pathological conditions has been highlighted by the emergence techniques such as Detection Apoptotic Retinal Cells and Adaptive Optics confocal Scanning Laser Ophthalmoscopy which have enabled single-cell visualisation vivo. Cell size previously used to stratify Ganglion (RGC) populations histological samples optic neuropathies, early work this field suggested that larger RGCs are more susceptible than smaller RGCs. More recently,...
There is great individual variation in response to general anesthetics (GAs) leading difficulties optimal dosing and sometimes even accidental awareness during anesthesia (AAGA). AAGA a rare, but potentially devastating, complication affecting between 0.1% 2% of patients undergoing surgery. The development novel personalized screening techniques accurately predict patient's GAs the risk remains an unmet clinical need. In present study, we demonstrate principle using fluorescent reporter...
Abstract Purpose Resveratrol is a natural polyphenol found in red wine and dark chocolate known for its antioxidant, anti‐inflammatory anti‐apoptotic properties. All these properties can be used to treat neurodegenerative diseases such as glaucoma. To date, resveratrol low solubility water bioavailability limits clinical use. The goal of this study was develop novel nanoparticle formulation assess it an ocular hypertension (OHT) rat model Methods nanoparticles (RNs) were formulated using...
Objective: Human intraocular pressure (IOP) is normally controlled within narrow limits to maintain ocular form and firmness while allowing abundant retinal perfusion. Dangerous IOP elevation can occur when this equilibrium challenged by common therapeutic manoeuvres which acutely increase volume or decrease eye wall volume, such as intravitreal injection scleral buckling. The purpose of study confirm the relationship between acute changes in an experimental model, review pertinent...
Aims/Purpose: Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system. Immunomodulatory treatments seek to reduce inflammation in MS but have limited effect on neurodegeneration. Resveratrol a natural polyphenol with antioxidant anti‐inflammatory properties which could be neuroprotective MS. The purpose this study compare oral intranasal administration resveratrol nanoparticles (RN) experimental autoimmune encephalomyelitis (EAE) mouse model...
Aims/Purpose: Papillophlebitis refers to an isolated optic disc oedema with venous engorgement in asymptomatic patients as defined by Walsh and Hoyt 1969. We report a case series of 3 who developed papillophlebitis related SARS‐CoV‐2 vaccination, type 2 diabetes or idiopathic. A literature review was also performed. Methods: Observational the covering cases performed using Pubmed, Embase Web Science. Cases presenting visual loss, RAPD, field defect retinal vascular occlusion were excluded....
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a demyelinating inflammatory of the central nervous system (CNS). It characterized by presence anti-MOG antibodies and core clinical event such as optic neuritis or transverse myelitis. The spectrum this includes neuritis, myelitis encephalopathy, seizures. Optic most frequent presentation at time diagnosis. can be relapsing/remitting [1]. start in all age groups, but average 30 years old [2].
Scleritis is a group of rare inflammatory diseases caused by an infectious or noninfectious aetiology. It has incidence 3.4 patients per 100 000 person-years [1]. can be divided as anterior and posterior. Noninfectious scleritis autoimmune disease in up to 50% cases, with rheumatoid arthritis granulomatosis polyangiitis being the most common Surgeries also induce it excessive conjunctival manipulation cauterisation [2]. classified diffuse, nodular, necrotising inflammation (called...