A5081860423- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Inflammatory Bowel Disease
- Neuroblastoma Research and Treatments
- MicroRNA in disease regulation
- Helicobacter pylori-related gastroenterology studies
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Microscopic Colitis
- RNA and protein synthesis mechanisms
- Immunodeficiency and Autoimmune Disorders
- Esophageal and GI Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Circular RNAs in diseases
- Digestive system and related health
- Gastrointestinal Bleeding Diagnosis and Treatment
- TGF-β signaling in diseases
- Cancer, Lipids, and Metabolism
- Gastroesophageal reflux and treatments
- Drug Transport and Resistance Mechanisms
- Gastric Cancer Management and Outcomes
- Protease and Inhibitor Mechanisms
- Folate and B Vitamins Research
- Ferroptosis and cancer prognosis
First Affiliated Hospital of Anhui Medical University
2014-2025
Anhui Medical University
2014-2025
Guangzhou University of Chinese Medicine
2025
Daping Hospital
2022-2025
Army Medical University
2022-2025
Hebei Agricultural University
2015-2024
Dezhou University
2023-2024
Shenyang Agricultural University
2024
The University of Texas Health Science Center at San Antonio
2013-2023
University of Chinese Academy of Sciences
2022
Abstract Motivation: Post-transcriptional and co-transcriptional regulation is a crucial link between genotype phenotype. The central players are the RNA-binding proteins, experimental technologies [such as cross-linking with immunoprecipitation- (CLIP-) RIP-seq] for probing their activities have advanced rapidly over course of past decade. Statistically robust, flexible computational methods binding site identification from high-throughput immunoprecipitation assays largely lacking however....
Translation regulation plays important roles in both normal physiological conditions and diseases states. This requires cis-regulatory elements located mostly 5′ 3′ UTRs trans-regulatory factors (e.g., RNA binding proteins (RBPs)) which recognize specific features interact with the translation machinery to modulate its activity. In this paper, we discuss aspects of UTR-mediated by providing an overview characteristics function main present region, like uORF (upstream open reading frame),...
Osteoblast differentiation and bone formation is stimulated by morphogenetic protein (BMP)-2 its downstream signaling molecules Smad1 -5 the osteoblast-specific transcription factor core-binding α1 (Cbfa1). Proteolytic degradation of Cbfa1 proteasome-dependent, intracellular concentrations are enhanced inhibition 26 S proteasome. mediated E3 ubiquitin ligase Smurf1 (Smad regulatory 1), but specific responsible for has not been identified. Because interacts with Smad1, whose Smurf1, we...
Bone morphogenetic proteins (BMPs) are required for normal postnatal bone formation and osteoblast differentiation. There is evidence from recent studies that BMP signaling in osteoblasts controlled by an ubiquitin-proteasome regulatory mechanism involving a cascade of enzymatic reactions. The specificity protein ubiquitination determined E3 ubiquitin ligases, which play crucial role defining substrate subsequent degradation 26S proteasomes. We have examined the ligase Smad factor 1...
Glioblastoma (GBM) is the most common and aggressive type of brain tumor. Currently, GBM has an extremely poor outcome there no effective treatment. In this context, genomic transcriptomic analyses have become important tools to identify new avenues for therapies. RNA-binding proteins (RBPs) are master regulators co- post-transcriptional events; however, their role in remains poorly understood. To further our knowledge novel regulatory pathways that could contribute gliomagenesis, we...
Abstract Background RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in RBP expression and are often observed cancer influence critical pathways implicated tumor initiation growth. Identification characterization oncogenic RBPs their regulatory networks provide new opportunities for targeted therapy. Results We identify the protein SERBP1 a novel regulator glioblastoma (GBM) development. High is prevalent GBMs correlates with poor patient survival...
Bone morphogenetic protein 2 (BMP-2) plays a critical role in osteoblast function.In Drosophila, Cubitus interruptus (Ci), which mediates hedgehog signaling, regulates gene expression of dpp, the ortholog mammalian BMP-2.Null mutation transcription factor Gli2, homolog Ci, results severe skeletal abnormalities mice.We hypothesize that Gli2 BMP-2 and thus differentiation.In present study, we show overexpression enhances promoter activity mRNA precursor cells.In contrast, knocking down by...
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) expression correlates with malignancy, but its role(s) in pathogenesis remains enigmatic. We interrogated the IGF2BP3-RNA interaction network pancreatic ductal adenocarcinoma (PDAC) cells. Using a combination of genome-wide approaches, we have identified 164 direct targets IGF2BP3. These transcripts encode proteins enriched for functions such as cell migration, proliferation, and adhesion. Loss IGF2BP3 reduced PDAC invasiveness...
Vascular smooth muscle cells (VSMCs) phenotype switch from contractile to proliferative is a pathological hallmark in various cardiovascular diseases. Recently, subset of long noncoding RNAs was identified produce functional polypeptides. However, the impact and regulatory mechanisms VSMCs switching remain be fully elucidated.
Abstract Background Crohn’s disease (CD) is an incurable chronic intestinal inflammatory with no recognized cause. It has been reported that the mechanosensitive ion channel PIEZO1 initiates proinflammatory responses. However, little known about role of in CD. Methods Ileum biopsies were obtained from 30 patients CD and 15 healthy volunteers. Clinical data collected to determine relationship between PIEZO1. First, HT29 cells incubated Yoda1 GsMTx4 (Grammostola spatulata mechanotoxin 4)...
Abstract Upon activation, the enzyme 5‐lipoxygenase converts arachidonic acid into principally three products, peptido‐leukotrienes, 5‐hydroperoxyeicosatetraenoic (5‐HETE) or leukotriene B 4 . We have shown that peptido‐leukotrienes (known as LTC , LTD LTE ) and 5‐HETE induce osteoclastic bone resorption receptors for are present on isolated avian osteoclast‐like cells. Here, we show effects of third metabolic product (5‐LO) pathway metabolism, LTB both in vivo vitro. Because production is...
Musashi1 (Msi1) is an evolutionarily conserved RNA-binding protein (RBP) that has profound implications in cellular processes such as stem cell maintenance, nervous system development, and tumorigenesis. Msi1 highly expressed many cancers, including glioblastoma, whereas normal tissues, its expression restricted to cells. Unfortunately, the factors modulate trigger high levels tumors are largely unknown. The mRNA a long 3' untranslated region (UTR) containing several AU- U-rich sequences....
Musashi1 (Msi1) is an evolutionarily conserved RNA-binding protein that has been implicated in processes like stem cell fate, nervous system development, and tumorigenesis via its activities as a specific regulator of translation. While Msi1 barely detected normal adult tissue, it observed to be highly expressed numerous tumor types (e.g. breast, colon, medulloblastoma, glioblastoma, et cetera). Unfortunately, the molecular cues are responsible for upregulation cancer cells largely unknown....
hnRNPs are polyvalent RNA binding proteins that have been implicated in a range of regulatory roles including splicing, mRNA decay, translation, and miRNA metabolism. A variety genome wide studies taken advantage methods like CLIP RIP to identify the targets sites proteins. However, due complex nature RNA-binding proteins, these incomplete without assays characterize impact RBP on target expression. Here we used suite high-throughput approaches (RIP-Seq, iCLIP, RNA-Seq shotgun proteomics)...
The conserved RNA-binding protein Musashi1 (MSI1) has emerged as a key oncogenic factor in numerous solid tumors, including glioblastoma. However, its mechanism of action not yet been established comprehensively. To identify target genes comprehensively and determine the main routes by which it influences glioblastoma phenotypes, we conducted individual-nucleotide resolution cross-linking immunoprecipitation (iCLIP) experiments. We confirmed that MSI1 preference for UAG sequences contained...
The ventricular-subventricular zone harbors neural stem cells (NSCs) that can differentiate into neurons, astrocytes, and oligodendrocytes. This process requires loss of cell properties gain characteristics associated with differentiated cells. miRNAs function as important drivers this transition; miR-124, -128, -137 are among the most relevant ones have been shown to share commonalities act proneurogenic regulators. We conducted biological genomic analyses dissect their target repertoire...
Background Insulin resistance is associated with atrial remodeling as well fibrillation (AF). However, there was limited evidence on the relationship of triglyceride-glucose index (TyG) index, a simple, valuable marker insulin resistance, AF. Thus, we aimed to investigate association between TyG and AF among hospitalized patients. Methods A retrospective observational study conducted in Daping Hospital, which included 356 patients from Department Cardiology. Clinical biochemical parameters...
An increasing number of patients with antithrombotic therapies are undergoing endoscopic retrograde cholangiopancreatography (ERCP). Interruption may be associated a higher risk symptomatic thromboembolic (TE) events. We aimed to investigate the TE events among ERCP. A retrospective cohort study on at for who had undergone ERCP from January 2016 October 2023 was conducted. total 2,482 were included in this study. compared within 30 days after between group treated agent and not using...
Here we report a patient with refractory benign esophageal stricture treated using endoscopic ultrasound (EUS) evaluation combined guidewire-guided cystotome therapy as new approach.
Background Uterine corpus endometrial carcinoma (UCEC) is one of the most common cancers in women, yet lacks specific and sensitive tumor markers for diagnosis, as traditional like CA125 show limited specificity. This study investigates clinical significance prognostic value CDH18, a calcium-dependent adhesion protein linked to progression, UCEC. Methods Clinical data from UCEC patients were sourced The Cancer Genome Atlas (TCGA) database. Pan-cancer analysis, differential expression...
For patients diagnosed with both lung cancer and severe coronary heart disease (CHD), the conflict between revascularization surgery remains to be settled balance how attenuate cardiovascular risk for shorten waiting time of anti-platelet therapy after revascularization. This study presents percutaneous intervention (PCI)-lobectomy hybrid (PLHS), its antithrombotic therapeutic strategy. From October 2020 June 2023, 14 patients, unstable angina resectable received PLHS. All procedures were...