A5101727172- Cancer-related molecular mechanisms research
- Bone Tissue Engineering Materials
- Structural Load-Bearing Analysis
- Cancer-related gene regulation
- Congenital limb and hand anomalies
- Cancer-related Molecular Pathways
- Dupuytren's Contracture and Treatments
- Hip disorders and treatments
- Parvovirus B19 Infection Studies
- Lung Cancer Research Studies
- Viral-associated cancers and disorders
- RNA modifications and cancer
- Immune Response and Inflammation
- Orthopaedic implants and arthroplasty
- Circular RNAs in diseases
- Neuroendocrine Tumor Research Advances
- Cryptography and Residue Arithmetic
- Orthopedic Infections and Treatments
- Sarcoma Diagnosis and Treatment
- 3D Printing in Biomedical Research
- Chromatin Remodeling and Cancer
- RNA Interference and Gene Delivery
- Nonlinear Optical Materials Studies
- Magnesium Alloys: Properties and Applications
- Acute Ischemic Stroke Management
Guangzhou University of Chinese Medicine
2025
Second Affiliated Hospital of Nanjing Medical University
2019-2025
Shanghai Electric (China)
2023-2024
Sun Yat-sen University
2000-2023
Wuhan University
2021-2023
Fifth Hospital In Wuhan
2021-2023
The First Affiliated Hospital, Sun Yat-sen University
2000-2023
University College London
2023
Nanjing Medical University
2019-2022
Huazhong University of Science and Technology
2018-2022
RNA interference (RNAi) and oxidative stress inhibition therapeutic strategies have been extensively utilized in the treatment of osteoarthritis (OA), most prevalent degenerative joint disease. However, synergistic effects these approaches on attenuating OA progression remain largely unexplored. In this study, matrix metalloproteinase-13 siRNA (siMMP-13) was incorporated onto polyethylenimine (PEI)-polyethylene glycol (PEG) modified Fe3O4 nanoparticles, forming a nucleic acid nanocarrier...
Lignin from different biomasses possess biological antioxidation and antimicrobial activities, which depend on the number of functional groups molecular weight lignin. In this work, organosolv fractionation was carried out to prepare lignin fraction with a suitable structure tailor excellent activities. Gel permeation chromatography (GPC) analysis showed that decreased fractions were obtained by sequentially anhydrous acetone, 50% acetone 37.5% hexanes. Nuclear magnetic resonance (NMR)...
Bacterial cellulose (BC) is an exopolysaccharide with unique properties that has been applied in various fields. However, the dense and intertwined nature of BC fibers limits its use certain applications, including 3D printing scaffolds for bone regeneration. In this work, a controllable BC-based bio-ink was successfully prepared by modifying neat through maleic acid (MA) treatment, aiming to promote tissue To achieve homogeneous dispersions while preserving crystalline chemical properties,...
Background Uterine corpus endometrial carcinoma (UCEC) is one of the most common cancers in women, yet lacks specific and sensitive tumor markers for diagnosis, as traditional like CA125 show limited specificity. This study investigates clinical significance prognostic value CDH18, a calcium-dependent adhesion protein linked to progression, UCEC. Methods Clinical data from UCEC patients were sourced The Cancer Genome Atlas (TCGA) database. Pan-cancer analysis, differential expression...
Gold nanorods (AuNRs) show great potential for versatile biomedical applications, such as stem cell therapy and bone tissue engineering. However, an indispensable shape-directing agent the growth of AuNRs, cetyltrimethylammonium bromide (CTAB) is not optimal biological studies because it forms a cytotoxic bilayer on AuNR surface, which interferes with interactions cells.Citrate-stabilized AuNRs various aspect-ratios (Cit-NRI, Cit-NRII, Cit-NRIII) were prepared by combination end-selective...
Introduction: Hepatic paraganglioma (HPGL) originates from the sympathetic nervous tissue in liver, and is an extremely rare type of paragangliomas. Till now, only 11 HPGL cases have been reported. Case presentation: A 49-year-old woman presented to our hospital with a lesion right lobe which grew 2 6 cm years. In addition, she had 6-year history diabetes. The patient was initially diagnosed as hepatocellular carcinoma hepatectomy performed. Surgical resection liver successful, but blood...
This study aimed to establish a comprehensive and sustainable approach the conservation of historical districts through “Cultural Landscape Security Pattern” (CLSP) theory. Deploying this theory can penetrate limitations posed by physical social-emotional factors, enabling resilient framework which coordinate long-term heritage protection with urbanization in more manner. Chaozong Street Changsha City, China, was taken as locus study, initiated quantitatively analyzing evaluating cultural...
Partial slow-release fertiliser substitution for urea combined with water-saving irrigation may synergistically improve rice yield, quality, water, and nitrogen (N) utilisation. A field experiment to evaluate different combinations of regimes: alternate wetting drying (AWD) flooding (FI), N strategies: N0 (no fertiliser); N1 (100% conventional N2 SCF – sulphur-coated N3 (70% + 30% urea), N4 (50% 50% urea) on efficient production. Results indicated that higher rates (N2 N3) increased total...
Smart biomaterials combined with stem cell-based therapeutic strategies have brought innovation in the field of bone tissue regeneration. However, little is known about precartilaginous cells (PCSCs), which can be used as seed and incorporated bioactive scaffolds for reconstructive therapy defects. Herein, iron oxide nanoparticles (IONPs) were employed to modulate fate PCSCs, resulting enhanced osteogenic differentiation potential both vitro vivo. PCSCs isolated from ring La-Croix extracted...
AbstractA transforming gene, designated Tx, was isolated from a human nasopharyngeal carcinoma (NPC) cell line CNE2 by transfection and molecular cloning techniques. The Tx gene analyzed using computer-based bioinformatics compared with the known sequences in EMBL GenBank databases. We found that contains immunoglobulin kappa light chain constant region, five intact joining regions J1-J5, recombination signal an N-segment besides classic regulatory such as TATA boxes, CAAT poly A signals,...
There is little evidence on the role of topical budesonide in reducing frequency adenoidectomy, although it was reported that can effectively ameliorate symptoms adenoid hypertrophy (AH). This study aimed to investigate possibility and safety alternatives adenoidectomy with a 12-week treatment nasal budesonide.One hundred patients AH were randomized receive either double-blind (1 mg once daily) or placebo for 2 weeks by transnasal nebulization. A further open study, spray (64 μg per nostril...
Legg‑Calvé‑Perthes disease (LCPD) is a pediatric form of femoral head osteonecrosis with unknown etiology. MicroRNAs (miRs) have been revealed to serve an important role in LCPD. MiR‑214 serves chondrogenesis. The aim the present study was investigate potential miR‑214 LCPD and underlying mechanisms. expression levels B‑cell lymphoma 2 (Bcl‑2)‑associated X protein (Bax) dexamethasone (DEX)‑treated TC28 cells, cartilage tissues, serum primary chondrocytes patients LCPD, healthy individuals...
<title>Abstract</title> <bold>Background: </bold>Heart failure (HF) is the leading cause of death in patients with maintenance hemodialysis (MHD). Biomarkers has an important guiding role early diagnosis, risk stratification, and prognostic assessment HF. Increasing studies have indicated that long non-coding RNAs (lncRNAs) played indispensable regulatory network This study was aiming to explore expression profiles lncRNAs treated MHD developing heart failure. <bold>Methods:...
Heart failure (HF) is the leading cause of death in patients with maintenance hemodialysis (MHD). Biomarkers has an important guiding role early diagnosis, risk stratification, and prognostic assessment HF. Increasing studies have indicated that long non-coding RNAs (lncRNAs) played indispensable regulatory network This study was aiming to explore expression profiles lncRNAs treated MHD developing heart failure. Peripheral blood mononuclear cells were isolated from 4 reduced ejection...
ABSTRACT Nm23 protein expression was analyzed by immunohistochemical staining using formalin-fixed, paraffinembedded sections from 39 cases with osteosarcomas and compared the histologic findings early metastasis for purpose of detecting nm23 in osteosarcoma elucidating clinical significance its expression. Immunoreactivity detected 48.7% total cases. There no statistical difference between metastasis, but there a trend to progress within 1 year after operation. The role as tumor suppressor...