A5037267960- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Nasal Surgery and Airway Studies
- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Facial Trauma and Fracture Management
- Pediatric health and respiratory diseases
- Infectious Diseases and Mycology
- Oral Health Pathology and Treatment
- Antibiotic Resistance in Bacteria
- Peer-to-Peer Network Technologies
- Soft tissue tumor case studies
- Distributed and Parallel Computing Systems
- Respiratory and Cough-Related Research
- Dermatology and Skin Diseases
- Bacterial Identification and Susceptibility Testing
- Cerebrospinal fluid and hydrocephalus
- Toxoplasma gondii Research Studies
- Peptidase Inhibition and Analysis
- Vibrio bacteria research studies
- Vascular Tumors and Angiosarcomas
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Caching and Content Delivery
The First Affiliated Hospital, Sun Yat-sen University
2015-2024
Sun Yat-sen University
2015-2024
Second Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2024
Putian University
2021-2023
The University of Texas Southwestern Medical Center
2019
Guangzhou Institute of Geochemistry
2018
Institute of Software
2010
Peking University
2010
Adaptation to selective pressures is crucial for clinically important pathogens establish epidemics, but the underlying evolutionary drivers remain poorly understood. The current epidemic of carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant threat public health. In this study we analyzed genome sequences 794 CRKP bloodstream isolates collected in 40 hospitals China between 2014 and 2019. We uncovered subclonal replacement predominant clone ST11, where previously prevalent...
Background Functional endoscopic sinus surgery (FESS) is considered to be the standard procedure for chronic rhinosinusitis with nasal polyps (CRSwNP). However, CRSwNP that accompanies asthma, results are not satisfying. Extensive (EESS) aimed at reducing inflammatory load has been indicated as a viable option refractory rhinosinusitis. Objective To evaluate clinical outcomes and safety of EESS (middle turbinate superior resection total ethmoidectomy) patients asthma. Methods This was...
In this first national bloodstream infection (BSI) surveillance program in China, we assessed the composition of pathogenic bacteria and trends for antimicrobial susceptibility over a 6-year period China.Blood bacterial isolates from patients at hospitals participating Blood Bacterial Resistant Investigation Collaborative System (BRICS) were collected January 2014 to December 2019. Only isolate species per patient was eligible full study period. Antibiotic-susceptibility testing conducted by...
Abstract Radiotherapy is unlikely to benefit all patients with head and neck squamous cell carcinoma ( HNSCC ). Therefore, novel method warranted predict the radiotherapy response. Our study aimed construct a micro RNA (mi )‐based nomogram clinical outcomes of receiving radiotherapy. We screened out 56 differential mi s by analyzing 44 paired tumor adjacent normal samples expression profiles from The Cancer Genome Atlas TCGA A total 307 adjuvant were randomly divided into training set n =...
The European Position Paper on Rhinosinusitis and Nasal Polyps proposes an assessment of clinical control chronic rhinosinusitis (CRS). However, there are limited data about the percentage postoperative control, no prediction models for uncontrolled CRS have been reported. aim study was to develop CRS.Retrospective case series.Patients (n = 136) who had undergone endoscopic sinus surgery at least 1 year prior were recruited assess control. Risk factors determined by logistic presented as...
BackgroundEosinophilic inflammation is a major phenotype associated with poorly controlled disease in nasal polyp patients. The difference between systemic and local eosinophilia relation to control understood.ObjectiveTo explore whether blood tissue eosinophil numbers are independent risk factors for poor patients polyp.MethodsBy using the electronic medical records database manual evaluation, 183 who had undergone endoscopic sinus surgery at least one year prior study complete data of...
Neutrophil accumulation has been observed in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the functions of neutrophils are poorly understood. Neutrophils produce neutrophil extracellular traps (NETs), which involved a variety inflammatory pathologies. LL-37 is only member cathelicidin family human.Our aims were to examine presence NETs CRSwNP and investigate regulatory effect on NET formation.Nasal polyp tissues investigated for by using immunofluorescent (IF) staining. The...
<i>Objective:</i> The mechanism of action involved in how <i>Dermatophagoides pteronyssinus</i> (Der p) 1 initiates the nasal allergic cascade is poorly understood. <i>Methods:</i> We detected proinflammatory cytokine production (GM-CSF, TNF-α, IL-1β, IL-6, and IL-8) associated signal molecules primarily cultured epithelial cells (NECs) from patients with rhinitis (AR) after Der p1 stimulation, using ELISA, RT-PCR, Western blot. also evaluated importance...
BackgroundCentral compartment atopic disease (CCAD) is a subtype of chronic rhinosinusitis (CRS). Research focusing on the endoscopic sinus surgery (ESS) outcomes CCAD limited. This study aimed to evaluate ESS in and compared 2 following subtypes: with nasal polyps (CRSwNP) concomitant polypoid central (CRSwNP/CC) CRSwNP not otherwise specified (CRSwNP NOS).MethodsThis case-control enrolled patients bilateral who underwent had at least 1 year follow-up. Patients were classified into CCAD,...
<b><i>Objective:</i></b> To evaluate the necessity of nerve sheath incision for treatment patients with traumatic optic neuropathy (TON) during endoscopic decompression. <b><i>Methods:</i></b> Seventy-four TON were enrolled and subjected to In 31 (group A), osseous decompression performed, in 43 B), alone was carried out. Visual acuity evaluated postoperatively. <b><i>Results: </i></b>After surgery, visual improved 47 74...
<i>Objectives:</i> To clarify the utility of a safe and effective endoscopic procedure for closing frontal sinus cerebrospinal fluid (CSF) leaks. <i>Methods:</i> A retrospective review all 15 patients seen at our hospital from 2002 to 2008 whose CSF leak originated within or recess. transnasal combined transfrontal approach was used repair leak. <i>Results Surgical Outcomes:</i> Four defects in recess 11 involved posterior wall sinus. Nine were repaired by...
<i>Objective:</i> To evaluate the efficacy of long-term clarithromycin (CAM) treatment in adult Chinese patients suffering from chronic rhinosinusitis without nasal polyps (CRSnNP). <i>Methods:</i> Thirty-three CRSnNP were enrolled and subjected to CAM for 12 weeks (250 mg daily). The total symptom scores (TNSS), resistance inflammatory mediators including interleukin (IL)-8 myeloperoxidase (MPO) evaluated at 0 12. Quality life (QoL) was assessed all by using...
Chronic rhinosinusitis (CRS) is characterized by the excessive production of mucus. However, molecular mechanism underlying mucin overproduction in CRS with or without nasal polyps (CRSwNP and CRSsNP, respectively) poorly understood. This study was conducted to assess importance transcription factor FoxA2 investigate targeting as a potential therapeutic strategy for mucus hypersecretion patients. We enrolled 15 CRSwNP patients, CRSsNP 10 normal controls this study. The expression levels...
Background In China, clarithromycin is considered an effective treatment option for chronic rhinosinusitis (CRS) due to its unique immunopathologic characteristics. Our study's aim was determine whether a topical steroid and combination better than single Chinese patients with CRS. Methods Patients CRS with/without nasal polyps were included in this study randomly assigned plus budesonide aqua spray group (CLM + BUD, 0.25 g/d 256 μg/d) or budesonide‐alone (BUD, μg/d). The period 3 months....
Background Osteopontin (OPN) is involved in cell survival, immunity, and tumor progression. The overexpression of OPN has been proposed as a biomarker progression metastasis for several types, but it still unclear whether up-regulated sinonasal inverted papilloma (SIP). Methods We enrolled 33 subjects with SIP 15 normal controls to determine the importance vascular endothelial growth factor (VEGF) SIP. Using immunohistochemistry, quantitative polymerase chain reaction, enzyme-linked...
Although the endoscopic anterior-to-posterior technique offers many advantages, long-term effects of iatrogenic trauma (removal uncinate process and anterior ethmoidal sinus) resulting from complete ethmoidectomy procedure used to gain full access optic nerve canal is unknown, sequelae such as nasal synechia sinusitis should not be ignored.The aim our study develop a less invasive for decompression.We proposed modified trans-sphenoidal surgical decompression in five patients with traumatic...
Central compartment atopic disease (CCAD) is a newly reported subset of chronic rhinosinusitis. It was considered associated with inhalant antigen. However, CCAD in Chinese population not fully studied yet.Prospective cohort study.This study aimed to describe the clinical manifestations and compared following two subtypes: sinonasal polyps concomitant polypoid central (CRSwNP/CC) CRSwNP otherwise specified (CRSwNP NOS). Also, we atopy non-atopy CCAD.We consecutively enrolled patients without...