A5062877002- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Nasal Surgery and Airway Studies
- Head and Neck Surgical Oncology
- Respiratory and Cough-Related Research
- Cystic Fibrosis Research Advances
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Genetic and Kidney Cyst Diseases
- Pediatric health and respiratory diseases
- Plant-Microbe Interactions and Immunity
- Fungal Plant Pathogen Control
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Ear and Nasal Anomalies
- Congenital gastrointestinal and neural anomalies
- Regional Development and Environment
- Gut microbiota and health
- MicroRNA in disease regulation
- Plant Disease Resistance and Genetics
- Soft tissue tumor case studies
- Mobile Health and mHealth Applications
- Ear and Head Tumors
- Inhalation and Respiratory Drug Delivery
- Medical Research and Treatments
Sun Yat-sen University
2014-2025
The First Affiliated Hospital, Sun Yat-sen University
2014-2025
Fujian Agriculture and Forestry University
2023
University of Pennsylvania
2011
Background Functional endoscopic sinus surgery (FESS) is considered to be the standard procedure for chronic rhinosinusitis with nasal polyps (CRSwNP). However, CRSwNP that accompanies asthma, results are not satisfying. Extensive (EESS) aimed at reducing inflammatory load has been indicated as a viable option refractory rhinosinusitis. Objective To evaluate clinical outcomes and safety of EESS (middle turbinate superior resection total ethmoidectomy) patients asthma. Methods This was...
BackgroundEosinophilic inflammation is a major phenotype associated with poorly controlled disease in nasal polyp patients. The difference between systemic and local eosinophilia relation to control understood.ObjectiveTo explore whether blood tissue eosinophil numbers are independent risk factors for poor patients polyp.MethodsBy using the electronic medical records database manual evaluation, 183 who had undergone endoscopic sinus surgery at least one year prior study complete data of...
Neutrophil accumulation has been observed in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the functions of neutrophils are poorly understood. Neutrophils produce neutrophil extracellular traps (NETs), which involved a variety inflammatory pathologies. LL-37 is only member cathelicidin family human.Our aims were to examine presence NETs CRSwNP and investigate regulatory effect on NET formation.Nasal polyp tissues investigated for by using immunofluorescent (IF) staining. The...
BackgroundCentral compartment atopic disease (CCAD) is a subtype of chronic rhinosinusitis (CRS). Research focusing on the endoscopic sinus surgery (ESS) outcomes CCAD limited. This study aimed to evaluate ESS in and compared 2 following subtypes: with nasal polyps (CRSwNP) concomitant polypoid central (CRSwNP/CC) CRSwNP not otherwise specified (CRSwNP NOS).MethodsThis case-control enrolled patients bilateral who underwent had at least 1 year follow-up. Patients were classified into CCAD,...
Background Herbal remedies predate written history and continue to be used frequently for many common ailments. The essential oil mixture standardized is a phytopharmaceutical with distillate of rectified oils eucalyptus, sweet orange, myrtle, lemon as active ingredients treat respiratory diseases such bronchitis rhinosinusitis. We evaluated the pharmacologic effects on primary human upper epithelial cultures specifically addressing electrolyte transport, cilia beat frequency (CBF), airway...
BackgroundLocal and systemic glucocorticoids are mainstay therapies for chronic rhinosinusitis. With respect to local glucocorticoids, nasal spray is used extensively, but some patients do not benefit from short-course treatment. Recently, clinicians have focused on the effects of high-dose in rhinosinusitis with polyps (CRSwNP), such as treatment using irrigation, transnasal nebulization, nose-dripping therapy (nasal drop) budesonide. However, there little data comparing effect regular oral...
BackgroundThe function of kallistatin in airway inflammation, particularly chronic rhinosinusitis with nasal polyps (CRSwNP), has not been elucidated.ObjectiveWe sought to investigate the role inflammation.MethodsKallistatin and proinflammatory cytokine expression levels were detected polyps. For vivo studies, we constructed kallistatin-overexpressing transgenic mice elucidate inflammation. Furthermore, plasma IgE cytokines airways evaluated kallistatin−/− rat model under a type 2...
Background In China, clarithromycin is considered an effective treatment option for chronic rhinosinusitis (CRS) due to its unique immunopathologic characteristics. Our study's aim was determine whether a topical steroid and combination better than single Chinese patients with CRS. Methods Patients CRS with/without nasal polyps were included in this study randomly assigned plus budesonide aqua spray group (CLM + BUD, 0.25 g/d 256 μg/d) or budesonide‐alone (BUD, μg/d). The period 3 months....
Nowadays, the heterogeneity of chronic rhinosinusitis (CRS) has attracted extensive attention. The histological patterns and clinical characteristics may vary greatly in different areas among groups people. Prior studies found a shift from neutrophilic inflammatory pattern to eosinophilic Asian cities. This study set out with aim investigating changes that have occurred past 18 years southern China exploring causes. Tissues, clinical, demographic were obtained 473 patients (91 2000-2001, 170...
Age-related changes in nasal bacterial microbiota of patients with chronic rhinosinusitis (CRS) remains unclear. In this study, we aimed to identify distinct characteristics between aged and younger CRS through 16S rDNA gene sequencing. Patients undergoing endoscopic sinus surgery were recruited separated into (≥60 years, median age = 66 N 17) (<60 35.5 14) patients. Diversity, composition metabolic activities compared. Results have shown that levels OTUs (p 0.0173) diversity (all p...
To assess the impact of risk factors on disease control among chronic rhinosinusitis (CRS) patients, following 1 year functional endoscopic sinus surgery (FESS), and combining to formulate a convenient, visualised prediction model.A retrospective nonconcurrent cohort study.A total 325 patients with CRS from June 2018 July 2020 at First Affiliated Hospital Sun Yat-sen University, Third Affliated Seventh University.Outcomes were time event measures: after year. The presence nasal polyps,...
Central compartment atopic disease (CCAD) is a newly reported subset of chronic rhinosinusitis. It was considered associated with inhalant antigen. However, CCAD in Chinese population not fully studied yet.Prospective cohort study.This study aimed to describe the clinical manifestations and compared following two subtypes: sinonasal polyps concomitant polypoid central (CRSwNP/CC) CRSwNP otherwise specified (CRSwNP NOS). Also, we atopy non-atopy CCAD.We consecutively enrolled patients without...
The role of miR-223-3p in dendritic cells (DCs) is unknown. This study aimed at investigating the effect on antigen uptake and presentation capacities DCs underlying molecular mechanism. FITC-OVA cell surface markers bone marrow-derived (BMDCs) were analyzed by flow cytometry. BMDCs transfected with mimic or inhibitor. Cytokine levels determined ELISA. CD4+ T differentiation was mixed lymphocyte culture assay. OVA treatment significantly downregulated BMDCs. inhibited OVA-induced expression...
Background MiR-146a has been shown to negatively regulate innate immune, inflammatory response and antiviral pathway, however, its role in the tolerogenic responses remains largely unknown. This study aimed investigate of miR-146a OVA-induced allergic inflammation dendritic cells (DCs).Methods Bone marrow-derived DCs (BMDCs) were treated with OVA (100 µg/ml) for 24 h. expressions assessed by quantitative RT-PCR. BMDCs transfected mimics or inhibitor. Cell surface markers analyzed flow...
Damage to the mucociliary clearance system is a typical change in pathogenesis chronic rhinosinusitis. However, mechanisms underlying cilia loss remain unclear. WDPCP key protein essential for ciliogenesis, and also an effector of planar cell polarity signaling system. In this study, we sought determine role patients with We demonstrated expression human sinonasal epithelium from rhinosinusitis control subjects. used air-liquid interface culture primary epithelial cells in-vitro model...
Obstructive sleep apnea (OSA) is a disorder with high prevalence in China. Standard diagnosis of OSA requires polysomnography (PSG). Currently, smart phone applications (apps) are widely used as an important source health guidance. However, the quality information provided by these apps has not been carefully assessed.We searched for available We designed evaluation scale that included scientific, functionality and usability, accountability domains. The Scientific domain index 16 items to...
Abstract Background Eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) is a refractory clinical phenotype high symptom burden and relapse rate. Steroid‐eluting stents are safe effective for reducing polyp size, burden, the need revision sinus surgery. In this study we aimed to evaluate efficacy safety of steroid‐eluting stent implantation on surgical outcomes patients ECRSwNP. Methods This prospective, multicenter, randomized, intrapatient‐controlled trial recruited 18 65 years...