A5045073916- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Sinusitis and nasal conditions
- Retinal Diseases and Treatments
- MicroRNA in disease regulation
- Nasal Surgery and Airway Studies
- Circular RNAs in diseases
- Plant biochemistry and biosynthesis
- Invertebrate Immune Response Mechanisms
- Neurobiology and Insect Physiology Research
- Retinal Imaging and Analysis
- Trace Elements in Health
- Spine and Intervertebral Disc Pathology
- Glaucoma and retinal disorders
- Dermatology and Skin Diseases
- Microplastics and Plastic Pollution
- Microbial Natural Products and Biosynthesis
- Shoulder Injury and Treatment
- Ophthalmology and Eye Disorders
- Thermal Regulation in Medicine
- Inflammasome and immune disorders
- Olfactory and Sensory Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoparticles: synthesis and applications
- Hormonal and reproductive studies
Sun Yat-sen University
2016-2025
Third Affiliated Hospital of Sun Yat-sen University
2022-2025
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2025
Beijing University of Chinese Medicine
2025
Harbin Medical University
2025
Shanghai University
2023-2024
Nantong University
2023-2024
The First Affiliated Hospital, Sun Yat-sen University
2016-2024
Hangzhou Normal University
2019-2024
Sun Yat-sen Memorial Hospital
2023-2024
Abstract Mesenchymal stem/stromal cells (MSCs) derived from placental tissue show great therapeutic potential and have been used in medical treatment, but the similarity differences between MSCs various parts of placenta remain unclear. In this study, we compared different perinatal tissues, including umbilical cord (UC), amniotic membrane (AM), chorionic plate (CP) decidua parietalis (DP). Using human leukocyte antigen (HLA) typing karyotype analysis, found that first three cell types were...
Abstract Background Nanoplastics (NPs) are now a new class of pollutants widely present in the soil, atmosphere, freshwater and marine environments. can rapidly penetrate cell membranes accumulate human tissues organs, thus posing potential threat to health. The heart is main power source body. But up now, toxicological effects long-term exposure nanoplastics on has not been revealed yet. Results We evaluated long term cardiac cell/tissue vitro vivo model. Furthermore, we explored molecular...
Abstract Background Pyroptosis has been demonstrated being closely associated with the inflammatory progression in chronic rhinosinusitis (CRS). However, platycodon D (PLD) emerged as a key anti-inflammatory mediator of various respiratory diseases. This study aims at investigating whether PLD could reduce CRS by inhibiting pyroptosis. Methods Nasal mucosal tissues from patients and control group (simple nasal septal deviation) were analyzed for morphological difference using hematoxylin...
Abstract Plants synthesize abundant terpenes through glandular trichomes (GTs), thereby protecting themselves from environmental stresses and increasing the economic value in some medicinal plants. However, potential mechanisms for simultaneously regulating synthesis GTs development remain unclear. Here, we showed that Conyza blinii could be synthesized capitate GTs. By treating with appropriate intensity of UV‐B, density diterpene content can increased. Through analyzing corresponding...
Wound healing is a complex pathophysiological process that occurs frequently in everyday pathology and remains challenge during the treatment of trauma. Previously, we prepared silver nanoparticle/chitosan oligosaccharide/poly(vinyl alcohol) (PVA/COS-AgNP) nanofibers via an electrospinning technique. These promoted proliferation human skin fibroblasts (HSFs) expression transforming growth factor TGF-β1 early stage wound repair, although specific mechanisms remain unclear. Therefore,...
Frozen shoulder (FS) is characterized by pain and limited range of motion (ROM). Inflammation fibrosis are accepted as main pathologic processes associated with the development FS. However, intrinsic mechanisms underlying remain unclear. We aimed to elucidate key molecules involved in explore new therapeutic targets for Synovial fibroblasts isolated from patient biopsies were identified using immunofluorescence. Western blotting, RT-qPCR, cell adhesion tests, would-healing assays used...
Mutation in CUL4B gene is one of the most common causes for X-linked intellectual disability (XLID). scaffold protein CUL4B-RING ubiquitin ligase (CRL4B) complex. While roles cancer progression and some developmental processes like adipogenesis, osteogenesis, spermatogenesis have been studied, mechanisms underlying neurological disorders patients with mutations are poorly understood. Here, using 2D neuronal culture cerebral organoids generated from patient-derived induced pluripotent stem...
Xiaoqinglong decoction (XQLD), first recorded in Shang Han Lun, is a traditional Chinese medicine prescribed for the treatment of allergic rhinitis (AR). XQLD alleviates clinical symptoms AR by inhibiting occurrence an inflammatory response, but specific regulatory mechanism remains unclear. NLRP3-mediated pyroptosis closely related to pathogenesis. Hence, this study aimed explore potential role pathway AR-associated pharmacological XQLD. BALB/C mice models was established using ovalbumin...
The Oxidative Balance Score (OBS) quantifies the overall oxidative stress burden, with higher scores indicating greater antioxidant (relative to prooxidant) activity. This study aimed examine association between peripheral arterial disease (PAD) and OBS. Data from National Health Nutrition Examination Survey (NHANES, 1999-2004) were analyzed for participants ankle-brachial index (ABI) measurements. total comprised a lifestyle OBS (four categories) dietary (16 factors). Logistic regression...
Objective: To study the efficacy of post-ischemic mild brain hypothermia lasting for different time intervals on cerebral ischemic reperfusion injury. Method: Male Sprague–Dawley rats were divided into a sham-operated group, normothermia (37–38° C) ischemia group and (31–32° group. The last was subdivided four groups: 30 minute plus 210 normothermia, 60 180 nomothermia,120 120 240 (n=8). Global established using Pulsinelli four-vessel occlusion model. Brain tissue collected following 20...
This study aimed to evaluate retinal microvascular density in patients with Parkinson's disease (PD) and its correlation visual impairment.This cross-sectional included 24 eyes of PD 23 healthy controls. All participants underwent ophthalmic examination, evoked potential (VEP) test, 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25), optical coherence tomography angiography (OCTA) examination. The between parameter was evaluated using Spearman analysis, the area under...
Glucose-6-phosphatase (G6Pase) and hexokinase (HK) are two key enzymes in the glycolysis gluconeogenesis pathways, which catalyze synthesis degradation of glucose insects, respectively. G6Pase HK play an important role insect growth by regulating metabolism glucose, leading to efficient other macromolecules. However, it is unclear whether these genes could be investigated for pest control through their actions on chitin metabolism. We studied potential functions regulation pathways RNAi...
Abstract: Circular RNAs (circRNAs) are reported to play pivotal regulatory roles in atherosclerosis progression. In the present study, we explored biological role of circRNA ubiquitin-specific peptidase 36 (circ_USP36; hsa_circ_0003204) oxidized low-density lipoprotein (ox-LDL)-induced dysfunction endothelial cells (ECs). RNA and protein levels were determined by reverse transcription-quantitative polymerase chain reaction Western blot assay, respectively. Cell proliferation was analyzed...
Objective The sub‐acromioclavicular (SAC) decompression is often performed during arthroscopic rotator cuff repair. However, the impact of SAC on patients with postoperative shoulder stiffness (POSS) are controversial and unclear. This study aim to evaluate additional repair in patients. Methods retrospective examined digital data from full‐thickness tears who underwent at a local institution. Patient‐reported outcomes were evaluated using American Shoulder Elbow Surgeons (ASES) Score,...
Pulmonary arterial hypertension (PAH) is characterized by increased vascular tone, altered vasoreactivity and remodeling induced smooth muscle cell proliferation. Similarities exist between cancer PAH. Aberrant expression of the tumor suppressor protein closely associated with Here, we tested hypothesis that a suppressor-axis inhibition 2 (Axin2) deficiency leads to PAH.We measured right ventricular systolic pressure in Axin2 knockout mice assessed patients. We found level was decreased both...