A5021264165- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Sinusitis and nasal conditions
- Dermatology and Skin Diseases
- Head and Neck Surgical Oncology
- Nasal Surgery and Airway Studies
- Olfactory and Sensory Function Studies
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Food Allergy and Anaphylaxis Research
- Oral and Maxillofacial Pathology
- IL-33, ST2, and ILC Pathways
- Bone Tumor Diagnosis and Treatments
- Infectious Diseases and Mycology
- Inhalation and Respiratory Drug Delivery
- Air Quality and Health Impacts
- Scheduling and Optimization Algorithms
- Stroke Rehabilitation and Recovery
- Neonatal Respiratory Health Research
- Advanced Chemical Sensor Technologies
- Advanced Manufacturing and Logistics Optimization
- IgG4-Related and Inflammatory Diseases
- Meningioma and schwannoma management
- Transcranial Magnetic Stimulation Studies
- Additive Manufacturing and 3D Printing Technologies
Beijing Tongren Hospital
2016-2025
Capital Medical University
2016-2025
Beijing Institute of Neurosurgery
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Tianjin University of Sport
2024-2025
Ministry of Education of the People's Republic of China
2025
Capital University
2025
Beijing Municipal Education Commission
2024
Tang Hospital
2024
Minzu University of China
2022-2024
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) remains a challenging clinical entity its propensity for recurrence. Tissue eosinophilia is hallmark of CRSwNP, and role in polyp recurrence subject much investigation. Objective The aim this study was to evaluate the association between parameters, especially tissue recurrence, identify optimal cutoff value as predictor Chinese subjects. Methods Overall, 387 patients CRSwNP were enrolled retrospective analysis postoperative...
Inflammatory diseases are often chronic and recurrent, current treatments do not typically remove underlying disease drivers1. T cells participate in a wide range of inflammatory such as psoriasis2, Crohn's disease3, oesophagitis4 multiple sclerosis5,6, clonally expanded antigen-specific may contribute to chronicity recurrence, part by forming persistent pathogenic memory. Chronic rhinosinusitis asthma airway that present comorbidities7. affects more than 10% the general population8. Among...
Abstract Background An epidemiological association among asthma, blood eosinophil level and chronic rhinosinusitis (CRS) is well established, but whether consistent genetic relationships exist, this reflects a shared etiology between CRS asthma or remains unclear. Methods Data from patients ( N = 1,255) healthy controls 1,032) were reviewed retrospectively to investigate associations clinical characteristics CRS. white cells in the UK biobank 173,480), Trans-National Asthma Genetic...
Background The inferior turbinate (IT) and nasolacrimal duct (NLD) are often sacrificed while managing the diffuse lesion of maxillary sinus (MS). We report a new approach to MS without ablation NLD IT. Methods This retrospective study enrolled 19 hospitalized patients (aged from 42 68 years) who underwent endoscopic surgery between 2003 2008. Twelve had inverted papilloma (IP), two nasal polyps, Kubo's postoperative cyst MS, one recurrent bone maxilla, dentigerous bleeding internal artery...
The effect of air pollution-related particulate matter (PM) on epithelial barrier function and tight junction (TJ) expression in human nasal mucosa has not been studied to date. This study therefore aimed assess the direct impact PM with an aerodynamic diameter less than 2.5 μ (PM2.5) TJ molecular cells.Air-liquid interface cultures were established cells derived from noninflammatory mucosal tissue collected patients undergoing paranasal sinus surgery. Confluent exposed 50 or 100 μg/mL PM2.5...
Defining the phenotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) prognosis may lead to delivery personalized treatment. This study aimed identify cellular CRSwNP using cluster analysis and define an algorithm for different clusters associated polyp recurrence.Overall, 366 patients were enrolled in this retrospective analysis. Eighteen variables, including clinical characteristics tissue/peripheral inflammatory cells assessments, selected factor Unsupervised was performed after...
There is little evidence on the efficacy of glucocorticoid transnasal nebulization therapy in patients with eosinophilic chronic rhinosinusitis nasal polyps (CRSwNP).We sought to evaluate immunologic and remodeling effects budesonide CRSwNP.Sixty CRSwNP were randomized receive or placebo treatment for 14 days by means a double-blind manner. Endoscopic polyp size scores (maximum = 6 points, Kennedy score) visual analog scale symptoms assessed before after treatment. Similarly, samples...
Optimization of skin prick test (SPT) panels, especially in view significant differences sensitizations patterns within different geographical areas, is an unmet need China. Our aim was to assess the and clinical relevance aeroallergen allergic rhinitis (AR) define minimal battery SPT allergens, classified according Köppen-Geiger climate map. Overall, 7148 subjects with self-reported AR completed a standard questionnaire were assessed for sensitization relevant allergens by SPT. 6340 (88.7%)...
There is no trial to assess the benefits of periodically using biologics during pollen season in patients with uncontrolled seasonal allergic rhinitis (SAR), who have moderate-to-severe symptoms even after standard-of-care. This aimed evaluate efficacy and safety add-on administration stapokibart, a humanised monoclonal antibody that targets interleukin-4 receptor alpha, SAR.
Most patients with severe asthma are sensitized to at least one allergen. Whether local immunoglobulin E (IgE) in induced sputum reflects control status has not been investigated.
Seasonal allergic rhinitis (SAR) is a global health issue, and the current standard of care (SoC) has limited effectiveness in controlling disease. There need for innovative treatments to better manage uncontrolled SAR advance beyond uniform SoC, biologics targeting type 2 inflammation driving promising. To evaluate efficacy safety Stapokibart, humanized monoclonal antibody interleukin-4 receptor subunit alpha, as an add-on therapy patients with SAR. The PHECDA multicenter, randomized,...
Emerging biologics that selectively target key cytokines present a promising therapeutic alternative for patients suffering from severe, uncontrollable chronic rhinosinusitis with nasal polyps (CRSwNP). Despite the limited availability of registered CRSwNP treatment in China, country is experiencing rapid development this field. It imperative to standardize application biologic agents management preparation their future integration into care pathway. The Rhinology Group, Chinese Society...
Background Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP), characterized by eosinophil‐predominant inflammation in mucosa, is a subject of much investigation. However, no satisfactory atraumatic clinical parameter has been established to date for prediagnosis this condition. The aim study was therefore compare the use computed tomography (CT) scans other parameters eCRSwNP. Methods This prospective cohort, single‐institution study. Two hundred consecutive CRSwNP patients...