A5100659401- Sepsis Diagnosis and Treatment
- Sinusitis and nasal conditions
- Asthma and respiratory diseases
- Photodynamic Therapy Research Studies
- Mesenchymal stem cell research
- Respiratory viral infections research
- Influenza Virus Research Studies
- Neonatal Respiratory Health Research
- Chemokine receptors and signaling
- IL-33, ST2, and ILC Pathways
- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Allergic Rhinitis and Sensitization
- Cholesterol and Lipid Metabolism
- Cell death mechanisms and regulation
- vaccines and immunoinformatics approaches
- Ocular Infections and Treatments
- Inflammation biomarkers and pathways
- Lipid metabolism and disorders
- Neutropenia and Cancer Infections
- Retinal Development and Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Natural Compounds in Disease Treatment
- Biomarkers in Disease Mechanisms
Ruijin Hospital
2014-2024
Shanghai Jiao Tong University
2015-2024
Shenzhen Center for Disease Control and Prevention
2024
Shanghai Changzheng Hospital
2024
Hangzhou Medical College
2021-2023
Zhejiang Provincial People's Hospital
2021-2023
Ningbo University
2021
China Pharmaceutical University
2014-2020
The First Affiliated Hospital, Sun Yat-sen University
2019
Sun Yat-sen University
2019
Abstract Purpose: Biomarkers for disease-specific survival (DSS) in early-stage melanoma are needed to select patients adjuvant immunotherapy and accelerate clinical trial design. We present a pathology-based computational method using deep neural network architecture DSS prediction. Experimental Design: The model was trained on 108 from four institutions tested 104 Yale School of Medicine (YSM, New Haven, CT). A receiver operating characteristic (ROC) curve generated the basis vote...
A long-held dogma posits that strong presentation to the immune system of dominant influenza virus glycoprotein antigens neuraminidase (NA) and hemagglutinin (HA) is paramount for inducing protective immunity against infection. We have deliberately violated this by constructing a recombinant strain A/PR8/34 (H1N1) in which expression NA HA genes was suppressed. down-regulated recoding respective with suboptimal codon pair bias, thereby introducing hundreds nucleotide changes while preserving...
Abstract Calcium-activated potassium ion channel-3.1 (KCa3.1) plays a pivotal role in the potassium-calcium exchange involved atopy. This study aimed to explore impact of lentiviral-mediated shRNA silencing KCa3.1 on allergic response murine rhinitis (AR) model. The BALB/c mice were divided into four groups: untreated AR group, negative control lentiviral KCa3.1-shRNA treated group and normal group. Concentrations ovalbumin (OVA)-specific IgE, histamine leukotrienes C4 (LTC4) serum IL-4,...
Staphylococcus aureus (S. aureus) is hard to be eradicated, not only due the emergence of antibiotic resistant strains but also because its ability form biofilm. Antibiotics are major approach treating biofilm infections, their effects unsatisfactory. One potential alternative treatments for controlling infections photodynamic therapy (PDT), which requires administration photosensitizer, followed by light activation. 5-aminolevulinic acid (ALA), a natural photosensitizer prodrug, presents...
Neutrophil accumulation has been observed in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the functions of neutrophils are poorly understood. Neutrophils produce neutrophil extracellular traps (NETs), which involved a variety inflammatory pathologies. LL-37 is only member cathelicidin family human.Our aims were to examine presence NETs CRSwNP and investigate regulatory effect on NET formation.Nasal polyp tissues investigated for by using immunofluorescent (IF) staining. The...
Cholelithiasis is one of the most common diseases biliary system. Neutrophil extracellular traps (NETs) in liver play an important role accelerating formation gallstones. The upstream mechanism NETs remains unclear. In this study, 16S rRNA sequencing was used to screen differential gut microbiota mice with Transcriptome differentially expressed core genes and signalling pathways Clostridium scindens that acted on human colonic epithelial cells. Western blotting verify protein expression TLR2...
Abstract Staphylococcus aureus is a common pathogen in chronic rhinosinusitis (CRS) patients, the pathogenesis of which involves ability to form biofilms and produce various virulence factors. Tobacco smoke, another risk factor CRS, facilitates S. biofilm formation; however, mechanisms involved are unclear. Here, we studied effect nicotine on formation expression virulence-related genes. strains isolated from CRS patients USA300 strain were treated with or untreated (control)....
Microcirculatory dysfunction is one of the main characteristics sepsis. Shenfu Injection (SFI) as a traditional Chinese medicine widely applied in clinical severe conditions. Recent studies have shown that SFI has ability to ameliorate sepsis-induced inflammation and improve microcirculation perfusion.
Acute pancreatitis (AP) with infectious complications has high mortality because of early-stage immunosuppression. The programmed cell death-1 (PD-1)/programmed death ligand 1 (PD-L1) pathway is an important host immunosuppression mechanism. Soluble PD-L1 (sPD-L1) expression regulates co-inhibitory signals in malignancies or autoimmune disorders; however, its effects AP are unknown. Here, we evaluated whether serum sPD-L1 involved immune dysfunction and assessed relationship early AP. Blood...
Mesenchymal stem cells (MSCs) have arisen the attention to be a new attractive therapeutic tool treating autoimmune diseases such as allergic rhinitis (AR). AR is chronic reversible inflammation caused by excessive activation of T-helper 2 (Th2) cells. Recently, MSCs been proposed therapy it can suppress some cytokines control allogeneic Th2 response and functions. However, how function reduce remains unclear. In this study, we aimed investigate role ectomesenchymal (ECTO-MSCs) derived from...
Abstract Sepsis is associated with significant mortality. Early diagnosis and prognosis of patients sepsis still a difficult clinical challenge. In this study, the ability plasma PTX3 (pentraxin 3), MCP1 (monocyte chemoattractant protein 1) Ang (angiopoietin)1/2 was investigated to evaluate severity sepsis. Blood samples were obtained from 43 A total 33 post‐surgery infections 25 healthy individuals served as controls. The results showed that PTX3, Ang2 significantly increased in on first...
Currently, influenza vaccine manufacturers need to produce 1–5 x 107 PFU of each strain fill one dose the current live-attenuated-influenza-vaccine (LAIV). To make a single inactivated (15 ug hemagglutinin), equivalent 1010 strains be grown. This high requirement is major drawback for manufacturing as well rapidly sourcing sufficient doses during pandemic. Using our computer-aided platform Synthetic Attenuated Virus Engineering (SAVE), we created candidate against pandemic H1N1 A/CA/07/2009...
Stress response is a fundamental mechanism for cell survival, providing protection under unfavorable conditions. Mitochondrial stress, in particular, can trigger mitophagy, process that restores cellular health. Exhaustive exercise (EE) form of acute mitochondrial stress. The objective this current study to investigate the impact EE on tau pathology pR5 mice, as well potential underlying mechanisms. To evaluate this, we examined levels total and phosphorylated hippocampus both with without...
Chemokines may play vital roles in breast cancer progression and metastasis. The primary members of chemokine decoy receptors (CDR), DARC D6, are expressed tumors lymphatic/hematogenous vessels. CDRs sequestrate the pro-malignant chemokines. We hypothesized that patients carrying different levels CDR expression tumor and/or host might have differing clinical outcomes.This prospective observational study measured both germline genotype D6 463 enrolled between 2004 2006. endpoint was...
Pancreatic cancer is a common malignant tumor with high mortality, and novel therapeutic options have focused on ameliorating its poor prognosis. TEOA, traditional Chinese herbal medicine, exhibits anti-inflammatory anti-cancer activities. Our recent study has shown that TEOA inhibits proliferation induces DNA damage in diffuse large B-cell lymphoma cells by activating the ROS-mediated p38 MAPK pathway. However, effects pancreatic remain unknown. In present study, we evaluated of...
Abstract To investigate whether serum‐soluble PD‐L1 (sPD‐L1) is a potential biomarker for identifying sepsis. This study enrolled 64 septic patients, 29 patients with acute appendicitis, 33 pancreatitis and 30 healthy volunteers. Sepsis was defined according to the 3.0 criteria.[1] The associated clinical parameters were recorded, blood samples collected on first day of diagnosis, serum sPD‐L1 levels measured using enzyme‐linked immunosorbent assays. Compared control group, significant...
Abstract Duffy antigen receptor for chemokine (DARC) and CCBP2, the two members of decoy family, restrain cell proliferation invasion through sequestrating cytotoxic chemokines. Our previous research clarified functional nonsynonymous single nucleotide polymorphisms (SNPs): rs12075 in DARC rs2228468 CCBP2 were significantly correlated with lymph node metastasis. However, role their genetic variations on survival breast cancer remains unclear. In present study, genotyped 806 patients primary...