A5101564217- Photosynthetic Processes and Mechanisms
- Antimicrobial Resistance in Staphylococcus
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Plant nutrient uptake and metabolism
- Bacterial Identification and Susceptibility Testing
- Bacterial biofilms and quorum sensing
- Immunodeficiency and Autoimmune Disorders
- Plant Molecular Biology Research
- Lipid metabolism and biosynthesis
- Pharmacogenetics and Drug Metabolism
- Nitrogen and Sulfur Effects on Brassica
- Pharmacological Effects and Assays
- Plant Stress Responses and Tolerance
- Plant Gene Expression Analysis
- Nutrition and Health in Aging
- Viral Infections and Immunology Research
- Neutropenia and Cancer Infections
- Genomics and Phylogenetic Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Antimicrobial Peptides and Activities
- Kruppel-like factors research
- COVID-19 Pandemic Impacts
- Natural Compounds in Disease Treatment
- Phytochemical compounds biological activities
Jiangsu University
2023-2024
Affiliated Hospital of Jiangsu University
2023-2024
Shanghai Public Health Clinical Center
2021-2024
Shanghai Medical College of Fudan University
2001-2023
Oil Crops Research Institute
2017-2023
Chinese Academy of Agricultural Sciences
2017-2023
Ministry of Agriculture and Rural Affairs
2020-2022
Tongji University
2021
Tongji Hospital
2021
Tianjin Medical University
2018-2020
Drought and heat stress are major causes of lost plant crop yield. In the future, high levels CO2, in combination other abiotic factors, will become a novel source stress. Little is known mechanisms involved acclimation responses plants to this though it has been demonstrated that shock transcription factors (Hsfs) response various stresses. study, we performed genome-wide identification systematic analysis genes Hsf gene family Brassica napus. A total 64 encoding proteins were identified...
The homeodomain-leucine zipper (HD-Zip) transcription factor family plays vital roles in plant development and morphogenesis as well responses to biotic abiotic stresses. In barley, a recessive mutation Vrs1 (HvHox1) changes two-rowed barley six-rowed which improves yield considerably. gene encodes an HD-Zip subfamily I factor. Phylogenetic analysis has shown that the rice genes Oshox12 Oshox14 are closest homologues of Vrs1. Here, we show ubiquitously expressed with higher levels developing...
Methicillin-resistant Staphylococcus aureus (MRSA), also known as oxacillin-resistant S. aureus, is a leading cause of community and hospital associated infections globally. In this work, we found that deletion the arlRS two-component system genes in USA300 USA500 strains resulted increased susceptibilities to oxacillin (8-16-fold decrease minimal inhibitory concentrations). USA300ΔarlRS, transcriptional levels mecA or blaZ showed no obvious change, while mRNA spx 4-fold at 4 h 6.3-fold 10...
Abstract Staphylococcus aureus is a common pathogen in chronic rhinosinusitis (CRS) patients, the pathogenesis of which involves ability to form biofilms and produce various virulence factors. Tobacco smoke, another risk factor CRS, facilitates S. biofilm formation; however, mechanisms involved are unclear. Here, we studied effect nicotine on formation expression virulence-related genes. strains isolated from CRS patients USA300 strain were treated with or untreated (control)....
Single-domain antibodies (sdAbs) have emerged as powerful therapeutic agents due to their small size, high stability, and superior tissue penetration. However, unlike conventional monoclonal (mAbs), sdAbs lack an Fc domain, limiting functional versatility manufacturability. To address this challenge, we developed TFDesign-sdAb, a deep learning-based generative-ranking framework that enables rational engineering of with tailored functionalities. Our integrates structure-aware diffusion model...
Objective . The purpose of this study was to investigate the relationship between miR-152-3p and KLF4/IFITM3 axis, thereby revealing mechanism underlying colon cancer occurrence development, consequently providing a promising target for treatment. Methods Bioinformatics methods were implemented analyze differential expression miRNAs mRNAs in cancer, confirm miRNA, predict downstream targeted mRNAs. qRT-PCR Western blot performed detect miR-152-3p, KLF4, IFITM3. CCK-8 colony formation assays...
As the COVID-19 epidemic is still ongoing, a more rapid detection of SARS-CoV-2 infection such as viral antigen-detection needs to be evaluated for early diagnosis disease. Here, we report dynamic changes antigens in nasopharyngeal swabs patients and its association with nucleic acid clearance clinical outcomes. Eighty-five were enrolled antigens, including 57 anti-SARS-CoV-2 antibody negative cases 28 positive cases. The antigen could detected 52.63% (30/57) at stage infection, especially...
Aims Previous studies suggest that small intestinal bacterial overgrowth (SIBO) is associated with type 2 diabetes. However, few have evaluated the association between SIBO and beta-cell function in The aim of this study was to evaluate whether SIBO. Materials methods One hundred four patients diabetes were included study. Based on presence SIBO, divided into SIBO-positive SIBO-negative groups. Oral glucose tolerance tests performed. Insulin sensitivity measured using 1/homeostasis model...
Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of both community- and hospital-associated infections. The antibiotic resistance virulence characteristics MRSA are largely regulated by two-component signal transduction systems (TCS) including the graRS TCS. To make relatively comprehensive insight into TCS in MRSA, bioinformatics analysis dataset GSE26016 (a S. HG001 WT strain vs. Δ mutant) from Gene Expression Omnibus (GEO) database was performed, total 563...
It has been reported that serum periostin levels are significantly higher in postmenopausal patients with osteoporotic fractures. Nonetheless, the of women different bone mass remain unclear.The objective study was to identify Chinese mass, and correlations between classical turnover markers (BTMs), mineral densities (BMDs) at sites.This enrolled 331 Shanghai; their clinical features were collected; traditional BTMs measured by ELISA or fully automated immunoassay analyzer; BMDs sites...
Abstract The evolution of C4 photosynthesis involved multiple anatomical and physiological modifications, yet our knowledge the genetic regulation remains elusive. In this study, systematic analyses were conducted comparing C3–C4 intermediate Moricandia suffruticosa its C3 relative Brassica napus (rapeseed). We found that leaves M. had significantly higher vein density than those B. napus, was further increased in under drought heat stress. Moreover, bundle sheath distance, as mean distance...
Abstract Nitric oxide (NO) is a key signaling molecule regulating several plant developmental and stress responses. Here, we report that NO plays an important role in seed oil content fatty acid composition. RNAi silencing of Arabidopsis S-nitrosoglutathione reductase 1 (GSNOR1) led to reduced content. In contrast, nitrate double mutant nia1nia2 had increased content, compared with wild-type plants. Moreover, the concentrations palmitic (C16:0), linoleic (C18:2), linolenic (C18:3) were...
To analyze the characteristics of distribution and drug resistance bacterial infection in several different parts hematology department inpatients Anhui Provincial Hospital from January 2010 to December 2014, including patients who had received hematopoietic stem cell transplantation (HSCT).Anti-microbial susceptibility test was done by Kirby-Bauer method automated systems data were analysed WHONET 5.6 software.A total 3 312 copies inspection samples analyzed, 2 716 (82%) blood other 596...
Abstract In recent years, fully human monoclonal antibodies (mAbs) are making up an increasing share of the pharmaceutical market. However, to improve affinity and efficacy antibodies, many somatic hypermutations could be introduced during maturation, which cause several issues including safety limit their application in clinic. Here, we propose a special class mAbs with limited level mutations, referred as germline-like mAbs. Remarkably, have high potent neutralizing activity vitro various...
The fruit-weight 2.2 (fw2.2) locus, which was first described in tomato, is known for controlling up to 30% of fruit mass. functions its homologs, the FW2.2-like (FWL) genes, have also been documented other diploid plants such as maize and rice. However, evolution contribution FWL gene family seed weight polyploid crops remain be explored. In this study, we deployed an integrated approach characterize allotetraploid crop, Brassica napus. A total 18 genes were identified designated BnFWL1-18....
Background: Congenital hyperinsulinemic hypoglycemia (HH) is a rare metabolic disease. Suppressed free fat acids, β-hydroxybutyrate levels and altered serum branched-chain amino acid were found during the acute course of HH. While scarce studies have described overall secondary spectrum changes. We thus investigate profiles in HH ketotic children analyze their distinguished features. Methods: A total 97 children, 74 with 23 hypoglycemia, 170 euglycemia control subjects studied...