A5007836634- Animal Virus Infections Studies
- Virus-based gene therapy research
- Animal Nutrition and Physiology
- Parvovirus B19 Infection Studies
- Mycotoxins in Agriculture and Food
- Herpesvirus Infections and Treatments
- Cancer-related molecular mechanisms research
- Microbial infections and disease research
- Antibiotic Resistance in Bacteria
- Viral gastroenteritis research and epidemiology
- MicroRNA in disease regulation
- Antimicrobial Peptides and Activities
- Higher Education and Teaching Methods
- Virology and Viral Diseases
- Salmonella and Campylobacter epidemiology
- Cytomegalovirus and herpesvirus research
- Circular RNAs in diseases
- Respiratory viral infections research
- Aquaculture disease management and microbiota
- Streptococcal Infections and Treatments
- Bacteriophages and microbial interactions
- Cancer Research and Treatments
- Education and Work Dynamics
- Probiotics and Fermented Foods
- Rabbits: Nutrition, Reproduction, Health
Henan University of Science and Technology
2016-2025
Luoyang Institute of Science and Technology
2021-2025
Henan Institute of Science and Technology
2024-2025
Johns Hopkins University
2024
Johns Hopkins Medicine
2024
Ministry of Education of the People's Republic of China
2024
Nanyang Normal University
2021-2024
Ministry of Education
2024
Carrier (United States)
2024
Département Santé Animale
2024
Zearalenone (ZEN) is considered one of the most serious mycotoxins contaminating grains and their by-products, causing significant economic losses in feed food industries. Biodegradation pathways are currently efficient solution to remove ZEN contamination from foods. However, low degradation rates vulnerability environmental impacts limit application biodegradation pathways. Therefore, main research objective this article was screen strains that can efficiently degrade survive under harsh...
The microRNA (miRNA) mdv1-miR-M4, a functional miR-155 ortholog encoded by oncogenic Marek's disease virus (MDV), has previously been suggested to be involved in MDV pathogenesis. Using the technique of bacterial artificial chromosome mutagenesis, we have presently evaluated potential role mdv1-miR-M4 oncogenesis very virulent (vv) strain GX0101. Unexpectedly, deletions Meq-cluster or alone from viral genome strongly decreased rather than abolished its oncogenicity. Compared GX0101,...
There is no information concerning the genotype of Canine parvovirus (CPV) currently circulating in Henan province, China. Therefore, aim present study was to provide insights into epidemiology and molecular characterization CPV province from 2009 2014.Nineteen thousand nine hundred seven dogs pet hospitals cities Luoyang, Anyang, Jiaozuo, Sanmenxia, Xinxiang, Zhengzhou between 2014 were investigated. Over 6-year period, 1169 CPV-positive cases identified morbidity infection ranged 4.16 8.06...
Probiotics are the most promising alternative to antibiotics for improving animal production and controlling pathogenic infections, while strains derived from natural hosts considered highly desirable due their good adaptation gastrointestinal tract. The aim of this study was screen Lactobacillus with broad-spectrum antibacterial activity broilers fed an antibiotic-free diet evaluate potential as poultry probiotics. A total 44 lactic acid bacteria (LAB) were isolated intestines healthy...
Oxidative stress and disruption of blood‒testis barrier permeability are considered key factors in the pathogenesis testicular inflammation, degeneration, functional impairment, which play crucial roles male infertility. Antimicrobial peptides (AMPs) internationally recognized as some most promising alternatives to antibiotics. However, molecular mechanisms by AMPs regulate oxidative testis still poorly understood. In this study, we orally administered 0.5 mg/kg antimicrobial peptide MPX...
Globally, the swine industry suffers significant economic losses due to presence of porcine reproductive and respiratory syndrome virus (PRRSV). Unfortunately, existing vaccines fail offer adequate protection against various strains PRRSV, there are currently no specific treatments available for this virus. In study, we screened four natural products identified cinnamaldehyde (CA) as an effective inhibitor PRRSV infection in Marc-145 cells. CA could achieve inhibition rate up 93% on N...
<title>Abstract</title> Antimicrobial peptide MPX is derived from wasp venom, known for its antibacterial activity against a wide range of bacteria. Researches have indicated that antimicrobial could induce dendritic cell maturation through interaction with surface receptors, thereby activating antigen presentation and initiating immune responses, which indirectly contributes to effects. However, the specific mechanism by activates cells remains unclear. The aim this study was investigate...
This study aimed to investigate the effect of lactic acid bacteria (LAB) and smectite on growth performance, nutrient digestibility blood parameters broilers that were fed diets contaminated with aflatoxin B1 (AFB1 ). A total 480 newly hatched male Arbor Acres randomly allocated into four groups six replicates 20 chicks each. The AFB1 (40 μg/kg) challenge or without (control) it supplemented (3.0 g/kg) LAB (4.0 × 1010 CFU/kg) based diet. trial lasted for 42 days. results showed during days...
Lactic acid bacteria (LAB) and the glutathione (GSH) pathway are protective against aflatoxin, but information on effect of LAB aflatoxin metabolism GSH activity in farm animals is scarce. This study aimed to investigate effects B (AFB) growth performance, metabolism, using 480 male Arbor Acres broiler chickens from d 1 35 age. Diets were arranged a 2 × factorial design, including AFB at 0 or 40 µg/kg feed 3 10 cfu/kg feed, was mixture equal amounts , . The results showed that there highly...
The objective of the present study is to determine effect phytic acid (PA), sodium oxalate (SO) and silicate (SS) on non-heme iron bioavailability in both presence absence ascorbic (AA) using an vitro digestion/Caco-2 cell model, levels AA needed promote Fe absorption from complexed with PA, SO or SS were also determined. results indicated that adding PA at 1:1, 3:1, 5:1 10:1 molar as compared decreased ferrous uptake by 55.80 %(P < 0.05), 72.33 % (P 73.32 73.26 respectively. Adding 51.40...
Background. Actinobacillus pleuropneumoniae , a member of the Pasteurellaceae family, is known for its highly infectious nature and primary causative agent pleuropneumonia in pigs. This disease poses considerable threat to global pig industry leads substantial economic losses due reduced productivity, increased mortality rates, need extensive veterinary care treatment. Due emergence multi-drug-resistant strains, Chinese herbal medicine considered one best alternatives antibiotics unique...
Abstract Background Marek’s disease (MD) is caused by the oncogenic virus (MDV), and a highly contagious avian infection with complex underlying pathology that involves lymphoproliferative neoplasm formation. MicroRNAs (miRNAs) act as oncogenes or tumor suppressors in most cancers. The gga-miR-155 downregulated MDV-infected chicken tissues lymphocyte lines, although its exact role tumorigenesis remains unclear. aim of this study was to analyze effects on proliferation, apoptosis invasiveness...
One hundred and 63 Bordetella bronchiseptica isolates from pigs, consisting of 65 isolated in 2003 98 2007, were tested for antimicrobial susceptibility to 17 agents by the disk diffusion method. All 163 B. sensitive polymyxin B cefoperazone/sulbactam; majority strains amikacin (149/163; 91.4%), gentamicin (132/163; 81.0%), ampicillin/sulbactam (127/163; 77.9%) ciprofloxacin (115/163; 70.6%). A high level resistance was found furazolidone (100%), ampicillin (90.2%), cefazolin (89.0%),...
In this study, we compared the virulence of most common serovars Glaesserella parasuis in China, 4, 5, 12, and 13 (36 strains total) BALB/c mice piglets. mice, median lethal doses (LD 50 s) four were roughly 9.80 × 10 7 –4.60 9 CFU, 2.10 8 –8.85 4.81 –7.01 1.75 –8.45 respectively. Serovar showed strongest virulence, followed by serovar but a significant difference was only observed between 5 13. The same differed significantly Virulent attenuated present all serovars, virulent piglets, 13,...
Citrobacter freundii is considered a ubiquitous organism and an opportunistic pathogen. Reports of C. freundii–associated disease in mammals have been very limited. We report outbreak septicemia encephalitis sheep, with high mortality rate; 13 adult sheep were found dead over 6-d period on farm central China that housed ~1,370 sheep. Three animals autopsied showed septicemia, congestion meningeal vessels, pleural effusion. was isolated abundance pure culture from 19 21 organs. All 3 isolates...
The present study aimed to investigate the effect of tetramethylpyrazine (TMP) supplementation on growth performance, Campylobacter jejuni (C. jejuni) carriage and antimicrobial peptides in epithelial tissue caecum skin rabbits. Five treatments included control C. challenge with addition TMP at 0, 50, 100 or 150 mg/kg diet. trial lasted for 35 days occurred first day feeding trial. results showed that worsened (P < 0.05) feed intake, body weight gain efficiency, whereas partially compensated...
The purpose of this study is to investigate the nutritional changes degraded rapeseed meal and its effects on growth performance, nutrient digestibility health status broilers. Raw (CON), by enzymolysis (protease, ERM), fermentation (Bacillus subtilis, FRM) or both (DRM) were included in diets at 25% fed 480 yellow-feathered broilers 22–63 d age. Results showed that peptide contents (≤1 kDa) increased (p < 0.05) from 4.13% (CON) 35.5% (ERM), 24.1% (FRM) 50.4% (DRM); glucosinolate erucic acid...
Listeria monocytogenes has been shown to exhibit antitumor effects. However, the mechanism remains unclear. Autophagy is a cellular catabolic process that mediates degradation of unfolded proteins and damaged organelles in cytosol, which double-edged sword tumorigenesis treatment outcome. Tumor cells display lower levels basal autophagic activity than normal cells. This study examined role molecular autophagy effects induced by LM, as well combined effect LM inhibitor chloroquine (CQ). We...
As a class I carcinogen, aflatoxin can cause serious damage to various tissues and organs through oxidative stress injuries. The liver, as the target organ of AFB1, is most seriously damaged. Biological methods are commonly used degrade AFB1. In our study, B1-degrading strain ZJ20 was screened from AFB1-contaminated feed soil, degradation AFB1 by investigated. whole genome analyzed, revealing genomic complexity ZJ20. 16S rRNA analysis showed 100% identity Bacillus subtilis IAM 12118. Through...