A5100335743- Microbial Natural Products and Biosynthesis
- Plant biochemistry and biosynthesis
- Natural product bioactivities and synthesis
- Advanced biosensing and bioanalysis techniques
- Healthcare and Venom Research
- Organophosphorus compounds synthesis
- Biological Stains and Phytochemicals
- CRISPR and Genetic Engineering
- Chromatography in Natural Products
- Chemical Synthesis and Analysis
- Biochemical and Molecular Research
- Traditional Chinese Medicine Analysis
- Fungal Biology and Applications
- Synthetic Organic Chemistry Methods
- Neurological diseases and metabolism
- Phytochemical Studies and Bioactivities
- Pharmacological Effects and Toxicity Studies
- Cyclopropane Reaction Mechanisms
- Dermatological diseases and infestations
- High-Temperature Coating Behaviors
- Multiple Myeloma Research and Treatments
- Sesquiterpenes and Asteraceae Studies
- Marine Sponges and Natural Products
- Phytochemistry and Bioactive Compounds
- Plant Pathogens and Fungal Diseases
East China University of Science and Technology
2018-2025
Henan University of Science and Technology
2025
Luoyang Institute of Science and Technology
2025
Fujian University of Traditional Chinese Medicine
2024
Central South University
2021
Jilin University
2021
First Affiliated Hospital of Henan University
2019
Institute of Microbiology
2014-2017
Chinese Academy of Sciences
2013-2017
King Saud University
2013
Taming highly enolizable aldehydes for catalytic asymmetric C–C coupling with nucleophiles remains an elusive challenge compared to widely explored simple alkyl or aryl aldehydes. Herein, we use ThDP-dependent enzymes realize the direct of 2-phosphonate in situ-generated dynamically reversible (acyl anions). Unlike NHC-mediated reactions that yield complex mixtures multiple adducts, our enzymatic process selectively produces biologically active β-hydroxy phosphonates high yields (up 95%) and...
Serial antibacterial furanoditerpenes caesanines A–D (1–4), possessing a cassane-type diterpenoid skeleton with an unusual N bridge between C-19/C-20, were identified from Chinese herb Caesalpinia sappan Linn. In addition, caesanine D (4) showed the first class of dicassane ethers. Their structures determined by different spectroscopic methods and ECD calculation. Caesanines A B exhibited strong activities against MRSA suggesting promising entry point for development anti-infective drugs.
Globally, the swine industry suffers significant economic losses due to presence of porcine reproductive and respiratory syndrome virus (PRRSV). Unfortunately, existing vaccines fail offer adequate protection against various strains PRRSV, there are currently no specific treatments available for this virus. In study, we screened four natural products identified cinnamaldehyde (CA) as an effective inhibitor PRRSV infection in Marc-145 cells. CA could achieve inhibition rate up 93% on N...
Two new noncyanogenic cyanoglucoside dimers, simmonosides A and B (1 2), were identified from the aqueous extract of jojoba (Simmondsia chinensis) leaves. Compounds 1 2 are first examples dimers containing a unique four-membered ring, representing novel dimerization patterns at α,β-unsaturated carbons nitrile group in γ,δ-unsaturated 2. Their structures elucidated based on spectroscopic evidence electronic circular dichroism (ECD) calculations. exhibit promising COX-2 inhibition activity,...
A series of new antimicrobial dibenzospiroketals epicospirocins, and their biosynthetic pathway, were investigated <italic>via</italic> molecular networking from phytopathogenic fungi EN09116 for the first time.
As magnetism and electricity are basic natural phenomena which inextricably linked together, the connections between electric anticorrosion properties exist objectively. Exploring relationship corrosion prevention is significant but challenging. Through researching X-ZnO solid solution doped by magnetic metal (X = Fe, Co, Ni, Cu, Mn), interesting meaningful results emerge. First, Cu-ZnO shows multistage self-assembly phenomenon, forming a pretty Rubik's cube structure. Second, experiment...
Nucleic acid detection plays a key role in diverse diagnosis and disease control. Currently available nucleic techniques are challenged by trade-offs among speed, simplicity, precision cost. Here, we described novel method, designated SENSOR (Sulfur DNA mediated sensing platform), for rapid detection. was developed from phosphorothioate (PT)-DNA sulfur binding domain (SBD) which specifically binds double-stranded PT-modified DNA. utilizes PT-DNA oligo SBD as targeting module, is linked with...
Background: Kaixinsan (KXS) decoction is a traditional Chinese herbal formulation commonly used to treat depression. This study aimed evaluate the efficacy and safety of KXS, which widely used, alone in combination with other therapies, for treatment The main objective was assess KXS depression as single agent or methods. Methods: Randomized controlled trials were systematically searched from several English databases no language restriction. Patients these studies met relevant diagnostic...
Berberine (BBR) has been reported to have potent anticancer activity and can increase the effects of chemotherapy drugs. The present study aims investigate whether BBR cisplatin (DDP) exert synergistic on osteosarcoma (OS) MG-63 cell line. In study, cells were treated with DDP alone or in combination. these therapeutics viability, colony formation, migration, invasion, nuclear morphology, apoptosis, cycle, as well their role regulating expression proteins related mitogen-activated protein...
Enzymatic catalysis has emerged as an attractive technology for organic synthesis but remains in its infancy constructing biologically-relevant chiral phosphonates. Here, we disclose a highly chemo- and enantioselective reactions between enolizable 2-phosphonate aldehydes aryl of This reaction mediated by PfBAL or mutant A28G features the first example cross-benzoin involving aldehydes, elusive challenge previously. Unlike small molecule NHC-mediated process that give complex mixture...
Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking. Serial reactions including dehydrogenation, demethylations, reduction, glycosylation methylation have been observed after incubation of IIA fungus Mucor rouxianus AS 3.3447. In addition, tanshinosides B (2) showed activities against serial clinical isolates oxacillin-resistant Staphylococcus aureus MIC values 0.78 μg/mL. This is...
Phytopathogenic fungi have attracted great attention as a promising source for new drug discovery. In the progress of our ongoing study bioactive natural products from an in-house phytopathogenic library, pathogenic fungus, Fusarium proliferatum strain 13294 (FP13294), was selected chemical investigation. Two novel aliphatic unsaturated alcohols named fusariumnols A and B (1 2), together with one previously characterized sesquiterpenoid lignoren (3) were identified. Structures 1-3 assigned...