A5019935150- Advanced biosensing and bioanalysis techniques
- Topological Materials and Phenomena
- Bryophyte Studies and Records
- Graphene research and applications
- Botany and Plant Ecology Studies
- Gut microbiota and health
- Biosensors and Analytical Detection
- Electrocatalysts for Energy Conversion
- Probiotics and Fermented Foods
- DNA and Nucleic Acid Chemistry
- 2D Materials and Applications
- Advanced Data Storage Technologies
- Quantum and electron transport phenomena
- CO2 Reduction Techniques and Catalysts
- Molecular Junctions and Nanostructures
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electric Motor Design and Analysis
- Parallel Computing and Optimization Techniques
- Carbohydrate Chemistry and Synthesis
- Magnetic Bearings and Levitation Dynamics
- Advanced Memory and Neural Computing
- Peatlands and Wetlands Ecology
- 3D Printing in Biomedical Research
- Inhalation and Respiratory Drug Delivery
- Advancements in Semiconductor Devices and Circuit Design
Institute of Physics
2021-2025
Chinese Academy of Sciences
2000-2025
National Laboratory for Superconductivity
2023-2025
First Affiliated Hospital Zhejiang University
2024-2025
Microsoft Research (United Kingdom)
2025
Chinese PLA General Hospital
2023-2024
Shijiazhuang Tiedao University
2023-2024
East China University of Science and Technology
2024
Chinese Research Academy of Environmental Sciences
2023-2024
China University of Mining and Technology
2022-2024
Bacteria colonize almost all parts of the human body and can differ significantly. However, population level transcriptomics measurements only describe average bacteria behaviors, ignoring heterogeneity among bacteria. Here, we report a droplet-based high-throughput single-microbe RNA-seq assay (smRandom-seq), using random primers for in situ cDNA generation, droplets barcoding, CRISPR-based rRNA depletion mRNA enrichment. smRandom-seq showed high species specificity (99%), minor doublet...
DNAzyme-based signal amplification circuits promote the advances in low-abundant miRNA imaging living cells. However, due to insufficient cofactor cells and unsustainable target utilization, self-powered self-feedback DNAzyme have rarely been achieved. Here, a MnO2 nanosheet-mediated entropy-driven catalyst (EDC)–DNAzyme nanoprobe (MnPFEDz) was demonstrated for sensitive of intracellular microRNA (miRNA). In this strategy, MnPFEDz formed by adsorbing EDC modules substrate probes on...
A recent experiment has reported the first observation of a zero-field fractional Chern insulator (FCI) phase in twisted bilayer MoTe$_2$ moir\'e superlattices [Nature 622, 63-68 (2023)]. The experimental is at an unexpected large twist angle 3.7$^\circ$ and calls for better understanding FCI real materials. In this work, we perform large-scale density functional theory calculation MoTe$_2$, find that lattice reconstruction crucial appearance isolated flat band. existence state $\nu = -2/3$...
SARS-CoV-2 has caused a severe pneumonia pandemic worldwide with high morbidity and mortality. How to develop preclinical model for recapitulating pathogenesis is still urgent essential the control of pandemic. Here, we have established 3D biomimetic alveolus-on-a-chip mechanical strain extracellular matrix taken into consideration. We validated that capable key physiological characteristics human alveolar units, which lays fundamental basis viral infection studies at organ level. Using...
The intestine is the largest digestive and immune organ in human body, with an intact intestinal mucosal barrier. Bifidobacterium longum specific gut commensals colonized for boosting immunity to defend against injury. In LPS-induced injury model, BL-10 was suggested boost immune. Detailly, compared mice, BL10 group significantly reduced (jejunum, ileum, colon) tissue injury, pro-inflammatory cytokines (TNF-α, IFN-γ, IL-2, IL-6, IL-17, IL-22, IL-12) levels myeloperoxidase activities....
Changes in the functions of intestinal barrier occur parallel with development sepsis. The protection by Bifidobacterium strains (BB, BL, BB12, and BLBB) was evaluated mice injected lipopolysaccharide (LPS). results revealed an increase ratio ileal villus length to crypt depth BLBB group compared that LPS group, as were number IgA+ plasma, CD4+/CD8+ T, dendritic cells. levels diamine oxidase (DAO) d-lactic acid serum lessened after injection group. In addition, exhibited increased expression...
Abstract Droplet‐based single cell sequencing technologies, such as inDrop, Drop‐seq, and 10X Genomics, are catalyzing a revolution in the understanding of biology. Barcoding beads key components for these technologies. What is limiting today barcoding that easy to fabricate, can efficiently deliver primers into drops, thus achieve high detection efficiency. Here, this work reports an approach fabricate dissolvable polyacrylamide beads, by crosslinking acrylamide with disulfide bridges be...
Abstract The strong suppression of Aedes albopictus on two Guangzhou islands in China has been successfully achieved by releasing males with an artificial triple- Wolbachia infection. However, it requires the use radiation to sterilize residual females prevent population replacement. To develop a highly effective tool for dengue control, we tested standalone incompatible insect technique (IIT) control A. urban area Changsha, inland city where recently emerged. Male mosquitoes were produced...
O-GlcNAcylation is a conserved post-translational modification that attaches N-acetyl glucosamine (GlcNAc) to myriad cellular proteins. In response nutritional and hormonal signals, regulates diverse processes by modulating the stability, structure, function of target Dysregulation has been implicated in pathogenesis cancer, diabetes, neurodegeneration. A single pair enzymes, O-GlcNAc transferase (OGT) O-GlcNAcase (OGA), catalyzes addition removal on over 3,000 proteins human proteome....
A novel DNA nanotetrad mediated crosslinking catalytic hairpin assembly (CCHA) is reported to generate clumps of cross-linked mesh products for high-contrast and simultaneous imaging multiple mRNAs in living cells.
Infant formula is currently an important food to cope with insufficient breastfeeding. Although 1,3-olein-2-palmitin (OPO) has been used in infant formula, its effects on the immune system, gut microbiota, and metabolites for infants remain unclear. This study constructed a mouse model of colonizing healthy feces using antibiotic treatment fecal microbial transplantation. Thus, gap between supplemented OPO human milk serum biochemistry, intestinal short-chain fatty acid production, was...
In this study, the antioxidant properties of intact cells (IC), cell-free supernatant (CFS), and extracts (CFE) whole genome sequencing Bifidobacterium bifidum E3 (B. E3), as well structural characteristics EPS-1, EPS-2, EPS-3, were evaluated. The results revealed that had potent DPPH (1,1-Diphenyl-2-picrylhydrazyl radical), hydroxyl, superoxide anion radical scavenging capacities, among which CFS was best. At genetic level, we identified a strong carbohydrate metabolism capacity, an EPS...
The objective of the article is to estimate influence factors on supply and demand trade credit in case buying selling agricultural materials agents rice farmers Mekong Delta, Vienam. estimated results from primary data 574 transactions show that there are three have positive coefficients with statistical significance two states (familiar time, agent number land area farmer's karma). geographical distance factor has demand, but state, this a coefficient negative coefficient. Three...
The emergence of neural network capabilities invariably leads to a significant surge in computational demands due expanding model sizes and increased complexity. To reduce size lower inference costs, recent research has focused on simplifying models designing hardware accelerators using low-bit quantization. However, numerical representation limits, scalar quantization cannot bit width than 1-bit, diminishing its benefits. break through these limitations, we introduce LUT-DLA, Look-Up Table...
This study was performed to investigate the prevalence of vitamin D deficiency in pregnant women Guizhou, China and its correlation with adverse infant maternal outcomes during perinatal period.In total, 220 who received care delivered Affiliated Hospital Guizhou Medical University from November 2014 April 2015 were enrolled. Each woman's serum concentration tested early pregnancy, period analyzed.The mean 29.5 ± 5.8 nmol/L. More than 90% had insufficiency. Additionally, 38.4% 22.2%...
A G-triplex, a new kind of DNA structure, has been identified as an intermediate in the folding G-quadruplexes. However, studies on G-triplexes are still very limited, and functions applications need to be further developed. In this paper, G-triplex sequence (5′-CTGGGAGGGAGGGA-3′, G3), obtained by truncating four bases (GGGA) from 3′ end 18-base G-quadruplex (G4), was found significantly decrease diffusion current methylene blue (MB). particular, we proved that (a) MB stabilized structure G3...
“Absorptive capacity,” a widely studied construct in management research, remains underexplored terms of its theoretical roots and development. In this curated collection, we present analyze articles from the Academy Management’s family journals, shedding light on organizations’ abilities to recognize, assimilate, apply external knowledge. We enhance our collective understanding absorptive capacity by delineating four schools thought that have been advanced through collection. addition...
Bifidobacterium longum is a common probiotic; both viable and heat-inactivated have many probiotic effects, such as anticancer effects. But some mechanisms of effects are still unclear, especially for probiotics. In this study, we analyzed the D42 on human colon cancer cells (HT-29). Cell proliferation, membrane permeability apoptosis were detected by using CCK-8 method, LDH method Annexin V-FITC/PI kits. The ROS level mitochondrial potential examined fluorescent probes DCFH-DA JC-1....