A5026249529- Cutaneous Melanoma Detection and Management
- Cell Image Analysis Techniques
- AI in cancer detection
- Genetic and rare skin diseases.
- Oral Health Pathology and Treatment
- melanin and skin pigmentation
- Cutaneous lymphoproliferative disorders research
- Genital Health and Disease
- Protein Degradation and Inhibitors
- Acute Myeloid Leukemia Research
- Sarcoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Entomological Studies and Ecology
- Medicine and Dermatology Studies History
- Melanoma and MAPK Pathways
- Dermatological diseases and infestations
- Cancer Immunotherapy and Biomarkers
- Infectious Diseases and Mycology
- RNA regulation and disease
- Nail Diseases and Treatments
- CAR-T cell therapy research
- Rabies epidemiology and control
- COVID-19 Impact on Reproduction
- CNS Lymphoma Diagnosis and Treatment
- Polyomavirus and related diseases
University Hospitals of Cleveland
2020-2025
Case Western Reserve University
2020-2025
University School
2021-2025
Weatherford College
2023
Roche (United States)
2023
Geisinger Health System
2018-2020
Abstract Purpose: Biomarkers for disease-specific survival (DSS) in early-stage melanoma are needed to select patients adjuvant immunotherapy and accelerate clinical trial design. We present a pathology-based computational method using deep neural network architecture DSS prediction. Experimental Design: The model was trained on 108 from four institutions tested 104 Yale School of Medicine (YSM, New Haven, CT). A receiver operating characteristic (ROC) curve generated the basis vote...
Background: Although cutaneous squamous cell carcinoma (SCC) arising from lichen planus is rare, hypertrophic (HLP) accounts for most of these malignant transformations. the mechanism pathogenesis remains unknown, reports similar premalignant conditions suggest a potential role tumor suppressor p16. This first study to our knowledge examine p16 expression in HLP comparison invasive SCC and normal skin its implications transformation. Methods: immunohistochemistry (n = 34) was performed...
Accurate prognostic biomarkers in early-stage melanoma are urgently needed to stratify patients for clinical trials of adjuvant therapy. We applied a previously developed open source deep learning algorithm detect tumor-infiltrating lymphocytes (TILs) hematoxylin and eosin (H&E) images melanomas. tested whether automated digital (TIL) analysis (ADTA) improved accuracy prediction disease specific survival (DSS) based on current pathology standards. ADTA was training cohort (n = 80) cutoff...
First reported in 1969, congenital smooth muscle hamartomas (CSMHs) typically present as skin-colored plaques commonly located on the trunk, buttock, and proximal portion of extremities infants. The appearance is variable may demonstrate hyperpigmentation, hypertrichosis, and/or epidermal changes form perifollicular papules.1-3 When biopsied, discrete, variably oriented hyperplastic bundles are found reticular dermis.3 CSMHs thought to originate from arrector pili muscles, blood vessel...
Rationale: Acute myeloid leukemia (AML)/myeloid sarcoma (MS) is risk-stratified based on cytogenetics. Although most congenital AML/MS have a dismal prognosis, certain genetic variants such as t (8, 16) [ KAT6A:: cAMP response element-binding protein (CREB) - binding fusion] and more recently 22) KAT6A::EP300 shown spontaneous remissions. KAT6A located chromosome 8p11 encodes protein, histone/lysine acetyltransferase enzyme. Numerous partner genes associated with include (16p13), EP300...
9577 Background: Patients with resected melanoma are at high risk for systemic recurrence. Quantifying the of recurrence can help identify need adjuvant immunotherapies, and accelerate acquisition survival statistics in clinical trials. Methods: 75 patients stages I, II, III seen Columbia University Medical Center between 2001 2014 The Icahn School Medicine Mount Sinai 2000 2010 were included based on availability tissue 24 months follow-up. Images scanned into tiff files (Aperio...
Background: Focal acantholytic dyskeratosis (FAD) and epidermolytic hyperkeratosis (EHK) are common incidental epidermal histologic findings within dysplastic nevi biopsies. We evaluate whether areas of FAD EHK biopsies stain with immunostains used to characterize melanocytic neoplasms. Methods: In this case series, a natural language search histopathology reports from our institution in the past year (2020–2021) identified nevus concurrent and/or EHK. Tissue samples were examined for...
Hydroa vacciniforme lymphoproliferative disorders (HVLPD) fall within the clinical spectrum of chronic active epstein barr virus (EBV) disease (CAEBVD), ranging from localised and/or indolent forms (classic HVLPD) to systemic with fever, hepatosplenomegaly and lymphadenopathy (systemic HVLPD). A preadolescent male 47XYY, multicystic dysplastic kidney, autism disorder Attention-deficit/hyperactivity (ADHD) presented photodistributed non-pruritic, non-painful necrotic papulovesicles...
10076 Background: Patients diagnosed with early stage melanoma are at risk of recurrence and death. Adjuvant therapy decreases but incurs toxicity expense. While tumor-infiltrating lymphocytes (TILs) improve prognosis, studies have shown conflicting results due, least in part, to inter-observer variability. Thus, TILs not included standard American Joint Committee on Cancer (AJCC) staging. Here, we quantitatively analyze hematoxylin eosin (H&E) images using two machine learning...
KAT6A , a histone/lysine acetyltransferase is located on 8p11 and has been reported in association with variety of partner genes like CREBBP (16p13), EP300 (22q13), LEUTX (9q13), NCOA2, NCOA3, ASXL2. Favorable prognosis spontaneous remission congenital AML t (8; 16) translocation have reported. More recently, single case report another gene 22) described. Here we an additional patient myeloid sarcoma the skin remission.
Verruca plana, also known as flat warts, are benign warts most commonly caused by human papilloma virus (HPV) type 3 and 10. The delayed eruption of in sites previous trauma has been described the literature, frequently within tattoos.1,2 Here, we report a case verruca plana arising at site metal particles embedded skin from blast injury.