A5052321704- Liver Disease and Transplantation
- Influenza Virus Research Studies
- Liver Disease Diagnosis and Treatment
- Advanced Cellulose Research Studies
- Hepatitis B Virus Studies
- Phytochemicals and Antioxidant Activities
- Clinical Nutrition and Gastroenterology
- Hepatitis C virus research
- Cell death mechanisms and regulation
- Aerogels and thermal insulation
- Bioactive natural compounds
- Alzheimer's disease research and treatments
- Anesthesia and Neurotoxicity Research
- Immunotherapy and Immune Responses
- Organ Transplantation Techniques and Outcomes
- Respiratory Support and Mechanisms
- Antibiotic Resistance in Bacteria
- Inflammasome and immune disorders
- Cancer Genomics and Diagnostics
- Respiratory viral infections research
- Retinopathy of Prematurity Studies
- Acupuncture Treatment Research Studies
- Horticultural and Viticultural Research
- Heat shock proteins research
- Apelin-related biomedical research
First Hospital of Jilin University
2017-2024
Hebei Medical University
2010-2024
Fourth Hospital of Hebei Medical University
2010-2024
Jilin University
2017-2024
Rongcheng City People's Hospital
2023
Henan Agricultural University
2019-2022
Xinxiang Central Hospital
2018-2022
Xinjiang Academy of Agricultural Sciences
2011-2021
Central South University
2017-2021
First Affiliated Hospital of Xiamen University
2021
Despite advances in DNA methylome analyses of cells and tissues, current techniques for genome-scale profiling methylation circulating cell-free (ccfDNA) remain limited. Here we describe a methylated CpG tandems amplification sequencing (MCTA-Seq) method that can detect thousands hypermethylated islands simultaneously ccfDNA. This highly sensitive technique work with genomic as little 7.5 pg, which is equivalent to 2.5 copies the haploid genome. We have analyzed cohort tissue plasma samples...
Background: Considering the pivotal role of inflammasome/pyroptosis in biological function, we visually analyzed research hotspots related to brain this work through method bibliometrics from Web Science (WOS) Core database over past two decades. Methods: Documents were retrieved WOS Collection on October 16, 2020. The search terms and strategies used for are as follow: # 1, “pyroptosis”; 2, “pyroptotic”; 3, “inflammasome”; 4, “pyroptosome”; 5 “brain”; 6, “# 1” OR 2” 3” 4”; 7, 5” AND 6”. We...
The safety of the immune complexes composed yeast-derived hepatitis B surface antigen (HBsAg) and antibodies (abbreviated as YIC) among healthy adults chronic patients has been proved in phase I IIa trial. A larger number for study dosage efficacy are therefore needed.Two hundred forty two HBeAg-positive were immunized with six injections either 30 microg YIC, 60 YIC or alum adjuvant placebo at four-week intervals under code. HBV markers DNA monitored during immunization 24 weeks after...
A hierarchically porous composite with mesoporous bioactive glasses (MBG) coated on macroporous poly(L-lactic acid) (PLLA) scaffolds has been prepared through a dip-coating process of PLLA into MBG sol solution and used as an antibiotic drug carrier. Characterization the structure morphology indicated stable homogenous deposition throughout framework scaffolds. In vitro studies in simulated body fluid (SBF) showed great improvements hydrophilicity, bioactivity, biodegradability if compared...
PurposeTo provide more basis for further diagnosis and differentiation Endocrine Mucin-Producing Sweat Gland Carcinoma (EMPSGC), we offer a case report comprehensive review of the epidemiology, immunohistochemical findings, molecular mechanisms underlying EMPSGC.Case descriptionWe herein present 70-year-old Chinese male patient who presented with painless, progressively enlarging skin mass at his right lateral canthus. Histopathological examination revealed solid papillary growth patterns...
Hepatocellular carcinoma (HCC) is a prevalent malignant tumor. Tumor markers are very useful in early diagnosis; however single marker rather limited. We launched test to increase the diagnostic sensitivity through combined detection.Serum concentration of three tumor-markers, Glypican-3 (GPC-3), Human-Cervical-Cancer-Oncogene (HCCR) and a-fetoprotein (AFP), were determined 189 samples: 101 cases HCC, 40 cirrhosis, 18 hepatitis 30 control healthy donors. Every was evaluated for its value by...
Heat shock protein 90α (HSP90α) maintains cell stabilization and regulates death, respectively. Recent studies have shown that HSP90α is involved in receptor interacting 3 (RIP3)‐mediated necroptosis HT29 cells. It known oxygen glucose deprivation (OGD) can induce necroptosis, which regulated by RIP3 neurons. However, it still unclear whether participates the process of OGD‐induced cultured neurons via regulation RIP3. Our study found occurs primary cortical PC‐12 cells following exposure to...
Staphylococcus aureus (S. aureus) is hard to be eradicated, not only due the emergence of antibiotic resistant strains but also because its ability form biofilm. Antibiotics are major approach treating biofilm infections, their effects unsatisfactory. One potential alternative treatments for controlling infections photodynamic therapy (PDT), which requires administration photosensitizer, followed by light activation. 5-aminolevulinic acid (ALA), a natural photosensitizer prodrug, presents...
Synaptic structural and functional damage is a typical pathological feature of Alzheimer's disease (AD). Normal axonal mitochondrial function transportation are vital to synaptic plasticity because they necessary for maintaining cellular energy supply regulating calcium redox signalling as well transmission vesicle release. Amyloid-β (Aβ) accumulation another hallmark AD that mediates loss dysfunction by targeting mitochondria. Therefore, it important develop strategies protect against...
Abstract Receptor‐interacting protein 3 (RIP3) plays an important role in the necroptosis signaling pathway. Our previous studies have shown that RIP3/mixed lineage kinase domain‐like (MLKL)‐mediated occurs retinal ganglion cell line 5 (RGC‐5) following oxygen‐glucose deprivation (OGD). However, upstream regulatory pathways of RIP3 are yet to be uncovered. The purpose present study was investigate p90 ribosomal S6 (RSK3) phosphorylation RGC‐5 OGD. results showed expression RSK3, RIP3, and...
Methamphetamine (METH) is one of the most widely abused synthetic drugs in world. The users generally present hyperthermia (HT) and psychiatric symptoms. However, mechanisms involved METH/HT-induced neurotoxicity remain elusive. Here, we investigated role heat shock protein 90 alpha (HSP90α) METH/HT (39.5°C)-induced necroptosis rat striatal neurons an
We herein report the use of natural sliced wood veneer as a porous lightweight substrate for supercapacitor electrodes, where PANI/RGO and PPy/RGO were employed active materials, both electrodes showed good electrochemical performance.
Abstract Motivation The pathogenesis of AD is complex and contributed by both genetic environmental factors. Recent work revealed a potential link between DNA methylation AD. However, genome-wide study to identify sites involved in still at an early stage. WGBS, up-to-date technology, was used this study. We investigated mouse brain profiles seven-month-old SAMP8 SAMR1 models through deep WGBS. Results According the results, global ML slightly decreased mice than (4.12% versus 4.19%). A...
Methamphetamine is one of the most prevalent drugs abused in world. abusers usually present with hyperpyrexia (39°C), hallucination and other psychiatric symptoms. However, detailed mechanism underlying its neurotoxic action remains elusive. This study investigated effects methamphetamine + 39°C on primary cortical neurons from cortex embryonic Sprague-Dawley rats. Primary were exposed to 1 mM 39°C. Propidium iodide staining lactate dehydrogenase release detection showed that triggered...
Abstract The inherent flammability and low strength of pure cellulose aerogels limit their use in several applications. In this study, novel nanofibers/synthetic polymeric composite with excellent flame retardancy increased were prepared under aqueous conditions an eco‐friendly freeze‐drying post‐curing process. This combined a rigid melamine–urea–formaldehyde network pentaerythritol phosphate melamine salt as inorganic retardant. latter is positively charged; hence, it could react...