A5101695994- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Esophageal and GI Pathology
- Gallbladder and Bile Duct Disorders
- Circular RNAs in diseases
- Liver Disease and Transplantation
- Medical Research and Treatments
- Soft tissue tumor case studies
- Berberine and alkaloids research
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- MRI in cancer diagnosis
- Heme Oxygenase-1 and Carbon Monoxide
- Cannabis and Cannabinoid Research
- Cancer-related gene regulation
- Gastrointestinal Tumor Research and Treatment
- Cancer Research and Treatments
Peking University
2009-2022
Peking University People's Hospital
2009-2022
Despite advances in DNA methylome analyses of cells and tissues, current techniques for genome-scale profiling methylation circulating cell-free (ccfDNA) remain limited. Here we describe a methylated CpG tandems amplification sequencing (MCTA-Seq) method that can detect thousands hypermethylated islands simultaneously ccfDNA. This highly sensitive technique work with genomic as little 7.5 pg, which is equivalent to 2.5 copies the haploid genome. We have analyzed cohort tissue plasma samples...
The prognostic benefits and safety of extended lymphadenectomy for hilar cholangiocarcinoma remain uncertain. available evidence is still insufficient concerning its retrospective aspect. aim this study to explore the clinical effect compared regional in patients with cholangiocarcinoma. Relay-HC trial a prospective, multicenter, randomized controlled trial. Seven hundred thirty-four eligible resectable perihilar across 15 tertiary hospitals China will be randomly assigned (1:1) receive...
Aims To evaluate stromal histopathological features and immunostaining expression for differential diagnosis of low- high-grade dysplastic nodules (HGDN) to early progressed hepatocellular carcinomas (eHCC, pHCC). Materials We evaluated sinusoid capillarisation (SC), solitary artery (SA), ductular reaction (DR), invasion six biomarkers (GPC3, HSP70, GS, CD34, CK19, EpCAM) in a series 97 cases. Results Stromal morphological changes, including SC, DR SA, exhibited significant differences...
Microwave ablation combined with hepatectomy for treatment of neuroendocrine tumor liver metastases
Delayed gastric emptying (DGE) is one of the most common complications after pancreaticoduodenectomy (PD). There currently no widely accepted procedure for PD to reduce incidence DGE. Our institution attempts perform subtotal gastrectomy in patients undergoing Here we aimed evaluate effectiveness and safety with resection.Patients who underwent between January 2014 December 2021 were reviewed. They stratified by extent into a conventional group (PD that resected approximately 1/3 distal...
Objective: To investigate the impact of promoter CpG island methylation on ABO mRNA expression in leukemia. Methods: 25 cases leukemia and 20 normal control were studied, cell lines K562、HL-60 Jurkat treated with different concentrations decitabine. PCR-SSP was used to identify genotype, RQ-PCR for bisulfite sequencing PCR DNA status. Results: ① The acute myeloid patients (10 cases) lymphoblastic 53.85% 18.22% respectively, which obviously higher than those (20 cases, 2.33%) chronic (5 2.12%...
e15124 Background: To compare the clinical effects of microwave ablation (MWA) and surgical resection in treatment small hepatocellular carcinoma (SHCC). Methods: 65 SHCC patients with intact data were enrolled this study. Among them, 30 treated by MWA, other 35 hepatectomy, an average age 59 years. According to follow-up results, Kaplan-Meier cumulative survival rates 1-, 3- 5-year two groups respectively calculated statistically compared. Results: Up December 31, 2102, except one patient...
Objective To analyze the risk factors for delayed gastric emptying (DGE) after pancreaticoduodenectomy.Methods Clinical data of 213 patients who underwent pancreaticoduodenectomy at our hospital from January 1996 to December 2011 was retrospectively analyzed.Results The overall incidence DGE 40.8％ (87/213).The grade A,grade B and C 14.1％ (30/213),14.5 ％ (31/213) 12.2％ respectively.Median postoperative stay significantly prolonged in with DGE:30.5,32 61 days A,B respectively versus 21 without...
Objective To investigate the significance of tumor markers CEA and CA19-9 in predicting clinicopathologic characteristics prognosis primary duodenal carcinoma. Methods A retrospective analysis 110 cases with carcinoma treated our hospital from January 1999 to December 2016 was conducted. ROC analysis, univariate multivariate were performed relationship between CEA, carcinoma. Kaplain-Meier method used analyze carcinoma. Results CEA level value for depth infiltration, lymphatic...
Objective To analyze the prevention and treatment of postoperative hemorrhage after pancreaticoduodenectomy. Methods The clinical data 142 patients undergoing pancreaticoduedenectomy from Jan 1995 to Dec 2008 were retrospectively analyzed. Results incidence was 14.1% (20/142), mortality caused by this complication 35% (7/20). Among these patients, intra-abdominal occurred in seven cases, gastrointestinal 14 with one case suffering both. There three four cases early delayed respectively....
Objective To evaluate the therapeutic effect of microwave ablation in combination with TACE for treatment primary liver carcinoma (PLC). Methods From Jan. 2004 to Dec. 2008, 63 PLC patients underwent ultrasound-guided (percutaneous or open) under general anesthesia. Repeated was used when an incompleted recurrence found during postoperative regular follow-up. Results These have received a total 82 sessions procedure (1 5 each patient). There were 2 early deaths procedure-related mortality...
Objective To evaluate the therapeutic effect or safety of selective paraesophagogastric devascularization with without splenectomy for treatment esophagogastric variceal hemorrhage. Methods The clinical data 70 patients a history hemorrhage from 2009 to 2015 were analyzed. 29 cases received spleen preserving and 41 given portoazygous plus splenectomy. Results Postoperative portal pressure in spleen-preserving group decreased 14%, that 23% (t=2.87, P=0.01). The average blood loss...
Objective To investigate the clinical efficacy and prognostic factors for combined caudate lobectomy radical resection plus broad lymph node dissection in patients of hilar cholangiocarcinoma. Methods The data follow-up results with cholangiocarcinoma surgically treated from Feb 2008 to 2017 were retrospectively analyzed. Result The R0 rate[72.2%(13/18)vs 43.9%(18/41)], operation time[(433±136)min vs(302±122)min], intraoperative blood loss [(1 789±1 091)ml vs(776±755)ml]and...
Objective To investigate the diagnosis and treatment of upper gastrointestinal hemorrhage caused by pancreatic segmental portal hypertension. Methods The clinical follow-up data 13 patients with hypertension from Jan 2010 to Dec 2017 were retrospectively analyzed. Results Of patients, 5 had pseudocysts 8 chronic pancreatitis. All them a history hematemesis or (and) tarry feces, 2 hemorrhagic shock. isolated gastric varices, varicose veins in lower esophagus. splenomegaly...
Objective To investigate the effect of Roux-en-Y hilar-jejunum anastomosis in surgical resection hilar cholangiocarcinoma. Methods The clinical data 31 patients with cholangiocarcinoma admitted from Feb 2009 to 2017 who underwent after were retrospectively analyzed. Results According Bismuth-Corlette classification there 6 cases IIIa, IIIb and 19 type IV. These all successfully anastomosis, intraoperative blood loss 50-4000 ml (on average 1146±1082 ml). The operation time was...
Abstract BACKGROUND: Delayed gastric emptying (DGE) is one of the most common complications after pancreaticoduodenectomy (PD). There currently no widely accepted procedure for PD to reduce incidence DGE. Our institution attempts perform subtotal gastrectomy in patients undergoing Here we aimed evaluate effectiveness and safety with resection. METHODS: Patients who underwent between January 2014 December 2021 were reviewed. They stratified by extent into a conventional group (PD that...