A5103679861- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Liver physiology and pathology
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Organ Transplantation Techniques and Outcomes
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- Nanoparticle-Based Drug Delivery
- Amoebic Infections and Treatments
- Bamboo properties and applications
- Cancer, Hypoxia, and Metabolism
- Molecular Communication and Nanonetworks
- Nutrition and Health in Aging
- Advanced Proteomics Techniques and Applications
- Cinema and Media Studies
- Parasitic Infections and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
- thermodynamics and calorimetric analyses
- Folate and B Vitamins Research
- Heat shock proteins research
Peking University
2011-2021
Peking University People's Hospital
2011-2021
Yunnan Agricultural University
2020
Qilu Hospital of Shandong University
2014
Yanbian University
2009
The mechanism underlying sorafenib resistance in hepatocellular carcinoma (HCC) remains unclear. Accumulating evidence suggests that tumor-initiating cells (TICs) are a pivotal driving force. Both CD44 and Hedgehog signaling play crucial roles TIC properties HCC. In this study, we explored the of evaluated therapeutic effect cotreatment with inhibitors HCC patient-derived organoid (PDO) models to improve treatment efficacy.We collected specimens establish PDO models. Cell viability malignant...
Background: The aim of this study was to characterize the disorder lipid metabolism in hepatocellular carcinoma (HCC). HCC is a worldwide disease. research into very limited. Study liver cancer tissue may have potential provide new insight mechanisms. Methods: A lipidomics based on Ultra high performance liquid chromatography-electronic spray ionization-QTOF mass spectrometer (UPLC-ESI-QTOF MS) and Matrix assisted laser desorption ionization-fourier transform ion cyclotron resonance...
To investigate the value of chaperonin containing TCP1, subunit 3 (CCT3) to predict prognosis patients with hepatocellular carcinoma (HCC) and determine its function in HCC progression.CCT3 expression levels were examined human non-cancerous liver tissues a variety cell lines by quantitative real-time PCR immunoblotting. CCT3 was suppressed small interfering RNA. The effects reducing cells tested. 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT) assay, counting experiment,...
// Xiao Cui 1, 2, * , Zhao Li Jie Gao 1 Peng-Ji Yan-bing Ni Ji-Ye Zhu Department of Hepatobilliary Surgery, Beijing Key Surgical Basic Research Laboratory Liver Cirrhosis and Cancer, Peking University People's Hospital, 100044, China 2 General The Second Hospital Anhui Medical University, Hefei 230601, These authors contributed equally to this work Correspondence to: Zhu, email: zhujiye_bmu@163.com Keywords: CXCL1, carcinogenesis, hepatocellular carcinoma, miR-200a Received: May 26, 2016...
Organ-like microenviroment and 3-dimensional (3D) cell culture conformations have been suggested as promising approaches to mimic in a micro-scale whole organ cellular functions interactions present vivo. We used this approach examine biologic features of hepatocellular carcinoma (HCC) cells. In study, we demonstrate that cells, fibroblasts, endothelial cells extracellular matrix can generate organoid-like spheroids enhanced numerous human HCC observed show the addition non-parenchymal such...
To investigate molecular alteration and expression of phosphatase tensin homolog deleted on chromosome 10 (PTEN) gene in hepatocellular carcinoma (HCC), to evaluate the correlation between PTEN cancer stem cell (CSC) markers prognostic value these markers.We evaluated changes CSC (CD133, epithelial adhesion molecule (EpCAM) CK19) 183 resection specimens by immunohistochemistry (IHC) detected phosphoinositide-3-kinase catalytic-alpha (PIK3CA) fluorescence situ hybridisation (FISH) some...
EGFR is a promising cell surface target for in vivo imaging that highly overexpressed hepatocellular carcinoma (HCC), common cancer worldwide. Peptides penetrate easily into tumors deep imaging, and clear rapidly from the circulation to minimize background. We aim demonstrate use of an specific peptide detect HCC xenograft mice with photoacoustic imaging. Nude implanted human cells overexpress were injected intravenously Cy5.5-labeled scrambled control peptides respectively. Photoacoustic...
Purpose: The aim of this study is to evaluate the incidence de novo malignancy after liver transplantation (LT) and compare with those among general Chinese population.Methods: A total 466 patients who had a minimum follow-up time 6 months were enrolled in study.All data medical records follow up retrospectively reviewed.Results: rate was 3.0% (14 patients).The median elapsed from transplant diagnosis 42 (range, 106 months).The cumulative risk for development 1.6%, 2.7%, 8.2% at 3, 5 10...
Ovarian cancer causes more deaths than any other malignant tumor of the female reproductive system. This is because condition usually goes undetected until late stages. The purpose present study to identify alterations in serum proteome profile during development ovarian and provide an experimental basis for discovering new valuable biomarkers early detection carcinoma. Surface-enhanced laser desorption/ionization-time flight (SELDI-TOF-MS) was used changes Fischer 344 rats with progress...
Aims To evaluate stromal histopathological features and immunostaining expression for differential diagnosis of low- high-grade dysplastic nodules (HGDN) to early progressed hepatocellular carcinomas (eHCC, pHCC). Materials We evaluated sinusoid capillarisation (SC), solitary artery (SA), ductular reaction (DR), invasion six biomarkers (GPC3, HSP70, GS, CD34, CK19, EpCAM) in a series 97 cases. Results Stromal morphological changes, including SC, DR SA, exhibited significant differences...
Hepatocellular carcinoma (HCC) is rising steadily in incidence, and more effective methods are needed for early detection image-guided surgery. Glypican-3 (GPC3) a cell surface biomarker that overexpressed early-stage cancer but not cirrhosis. An IRDye800-labeled 12-mer amino acid sequence was identified, specific binding to GPC3 validated vitro orthotopically implanted HCC tumors vivo. Over 4-fold greater affinity 2-fold faster kinetics were measured by comparison with previous peptides....
Hepatocellular carcinoma (HCC) is still one of common malignant cancers worldwide, with increasing incidence and mortality rates. Early diagnosis effective treatment for HCC remain to be explored. This article introduces the research advances in early specific therapies 2016, such as molecular markers targeted therapy HCC, main therapeutic regimens, robot-assisted liver resection, no-touch radiofrequency...
Objective To investigate the relationship of nutritional status with liver function and clinical outcomes cancer patients treated surgery.Methods Altogether 112 hospitalized undergoing surgical treatments for were enrolled from October 2011 to 2013.Their general data collected,including creatinine-height index (CHI),arm circumference,grip strenghth,albumin,prealbumin,and transferrin.The was assessed using Patient-Generated Subjective Global Assessment (PG-SGA).The Child-Pugh...
Objective To observe the efficacy of using sorafenib in preventing and treating tumor recurrence after liver transplantation for patients with primary hepatic carcinoma exceeding Milan criteria.Methods From March 2008 to June 2010,30 criteria were randomized into 2 groups,each group 15 cases.The experimental received oral administration (400 mg bid) ; control capecitabine (1500 14 days every 4 weeks.The patient without 18 months stoped taking medication.The recurrent maintained original dose...
Objective To analyze clinical features,surgical treatment efficacy and prognostic factors of bone metastasis patients after liver transplantation for hepatocellular carcinoma.Methods A retrospective data 20 carcinoma from July 2000 to January 2010 were received.The effect surgery aimed at was evaluated.Univariate multivariate risk analyzed.Results The median survival time these 7.5 months 1-year rate only 20％.Surgical could relieve pain promote patients' peformance status...
Objective To observe the efficacy of Sorafenib in preventing and treating tumor recurrence after liver transplantation for patients with primary hepatic carcinoma beyond Milan criteria.Methods From March 2008 to June 2010,30 exceeding criteria were randomized into 2 groups,each group 15 cases.Beginning one month posttransplantatoin experimental received oral administration (400 mg bid),while those control Capecitabine ( 1500 bid) 14 days every 4 weeks.Drug was withdrawn without 18 months...
Objective To study the effect on humoral immunity with combination of CsA and IL-2 fusion protein. Methods Forty C57/B6 mice were evenly divided into four groups,after receiving skin graft from DBA mouse.Mice in experimental group was given CsA(30 mg/kg,ip) plus IL-2/Fc (1μg,ip) while control only CsA,each HBV vaccine after surgery (2 μg,im),while blank transplantation.The fourth left intact.Fourteen days later,the level HBSAb,IL-4,IL-10,IFN-γ,IL-2 measured ELISA IL-21and FoxP3 expression...