A5100651520- RNA modifications and cancer
- MicroRNA in disease regulation
- Supramolecular Chemistry and Complexes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Virus-based gene therapy research
- Mechanisms of cancer metastasis
- Epigenetics and DNA Methylation
- Cultural Heritage Materials Analysis
- RNA Interference and Gene Delivery
- Cancer Research and Treatments
- CRISPR and Genetic Engineering
- Neuroscience and Neural Engineering
- Esophageal Cancer Research and Treatment
- CAR-T cell therapy research
- Microbial Metabolism and Applications
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- Molecular Sensors and Ion Detection
- Cancer-related molecular mechanisms research
- Advanced Memory and Neural Computing
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Mechanisms and Therapy
- Fibroblast Growth Factor Research
University of Macau
2018-2025
Peking University
2019-2024
Peking University People's Hospital
2019-2024
Wuhan University
2001-2024
Wuhan University of Science and Technology
2023
South Central Minzu University
2023
Institute of Archaeology
2023
University of Chinese Academy of Sciences
2023
Yunnan University
2023
State Key Laboratory of Transducer Technology
2023
Dysbiosis of gut microbiota are commonly reported in autism spectrum disorder (ASD) and may contribute to behavioral impairment. Vitamin A (VA) plays a role regulation microbiota. This study was performed investigate the VA changes functions children with ASD. Sixty four, aged 1 8 years old ASD completed 6-month follow-up intervention. High-performance liquid chromatography used assess plasma retinol levels. The Autism Behaviour Checklist (ABC), Childhood Rating Scale (CARS) Social...
The mechanism underlying sorafenib resistance in hepatocellular carcinoma (HCC) remains unclear. Accumulating evidence suggests that tumor-initiating cells (TICs) are a pivotal driving force. Both CD44 and Hedgehog signaling play crucial roles TIC properties HCC. In this study, we explored the of evaluated therapeutic effect cotreatment with inhibitors HCC patient-derived organoid (PDO) models to improve treatment efficacy.We collected specimens establish PDO models. Cell viability malignant...
Open AccessCCS ChemistryRESEARCH ARTICLE6 Jun 2022Biomimetic Recognition-Based Bioorthogonal Host–Guest Pairs for Cell Targeting and Tissue Imaging in Living Animals Yan-Long Ma†, Chen Sun†, Zeshun Li, Ziyi Wang, Jianwen Wei, Qian Cheng, Li-Shuo Zheng, Xiao-Yong Chang, Kai Ruibing Wang Wei Jiang Ma† Shenzhen Grubbs Institute, Guangdong Provincial Key Laboratory of Catalysis, Department Chemistry, Southern University Science Technology, 518055 , Sun† State Quality Research Chinese Medicine,...
Allosteric stiffening of a portion protein surface is strategy used in nature to regulate oligomerization and provide crucial functions for cells. However, similar selectively control part compound dynamics remains elusive. Here we show that cucurbit[n]uril (CB[n]) macrocycles can bind almost all portions tetratopic guest molecule, the different parts extents. “Host‐guest” interactions were found be instrumental “freezing” molecular motions. The combination 1H‐NMR (1D, 2D), DOSY, VT‐NMR,...
Allosteric stiffening of a portion protein surface is strategy used in nature to regulate oligomerization and provide crucial functions for cells. However, similar selectively control part compound dynamics remains elusive. Here we show that cucurbit[n]uril (CB[n]) macrocycles can bind almost all portions tetratopic guest molecule, the different parts extents. “Host‐guest” interactions were found be instrumental “freezing” molecular motions. The combination 1H‐NMR (1D, 2D), DOSY, VT‐NMR,...
Runt-related transcription factor 3 (RUNX3) is a tumor suppressor in many human solid tumors. In this study, renal cell carcinoma (RCC) microarray analysis showed that the level of RUNX3 expression was lower RCC tissue than adjacent normal tissues, and correlated with depth invasion (pT stage) (P<0.001) Tumor Node Metastasis (TNM) stage (P<0.001). negatively poor 5-year overall disease-free patient survival. suppressed metastasis increased levels E-cadherin, an important marker...
WW domain-containing E3 ubiquitin protein ligase1 (WWP1) is reported to be upregulated in many types of human cancers; however, its expression and function intrahepatic cholangiocarcinoma (ICC) remain unknown. Here, this study we investigated the pattern, clinical prognosis, tumor biological functions, molecular mechanisms WWP1 ICC. The patient tissues was detected by western blotting, immunohistochemistry (IHC), immunofluorescence. CCK-8, colony formation, EdU, transwell, xenograft models...
A viologen derivative carrying a benzimidazole group (V-P-I 2+ ; viologen-phenylene-imidazole V-P-I) can be dimerized in water using cucurbit[8]uril (CB[8]) the form of 2:2 complex resulting negative shift guest pKa , by more than 1 pH unit, contrasting with positive usually observed for CB-based complexes. Whereas protonation is unclear NMR, silver cations have been used probing accessibility imidazole groups The capacity buried reduced, suggesting that CB[8] could trigger proton release...
A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound has showed pH actuated ring translocation high fatigue resistance promising features against cancer cells.
Abstract Cancerous inhibitor of protein phosphatase 2A (CIP2A), an endogenous (PP2A) inhibitor, has been identified as oncoprotein in promoting cancer initiation and progression several types cancer. However, the expression role played by CIP2A pathogenesis multiple myeloma (MM) remain unclear. In this study, we showed that was overexpressed human MM cell lines patients’ bone marrow tissues. Clinicopathologic analysis significantly correlated with clinical stage percent plasma cells marrow....
Off-pump coronary artery bypass grafting (OPCAB) is a popular treatment for patients with ischemic heart disease, especially high-risk patients. However, whether OPCAB can lead to better clinical outcomes than on-pump (ONCAB) in enlarged ventricles remains controversial. This prospective randomized study was designed characterize comparison of early outcome and mid-term follow-up following ONCAB versus triple-vessel disease ventricles.Prospective trial treated at The First Affiliated...
Replication‐competent adenovirus ( RCA d) has been used extensively in cancer gene therapy, and tumor‐selection is critical for the use of replication‐competent adenovirus. Here we investigated anti‐tumor characterization oncolytic virus, whose E 1 A under control a renal cell carcinoma specific promoter – G 250 promoter. The constructed virus 250‐ K i67 armed with transgene i67‐si RNA , ZD 55‐ also B ‐55 KD deleted. tumor‐specific expression was demonstrated by W estern blot...
// Jun Yin 1, 2, * , Weifeng Tang Tao Long Huiwen Pan 1 Jianchao Liu Lu Lv Chao Yijun Shi Jingfeng Zhu Yangyong Sun Aizhong Shao Qiang Zhou Zhengbing Ren Guowen Ding Suocheng Chen Yan 3 Yao 4 Hao 5 Yulan Haiyong Gu 6 Cheng Qian 2 Liming Wang 7 Qun and Lijie Tan Department of Cardiothoracic Surgery, Affiliated People’s Hospital Jiangsu University, Zhenjiang, Jiangsu, 212002, China Thoracic Zhongshan Fudan Shanghai, 200032, Genesky Biotechnologies Inc., 201315, Gastroenterology,...
Abstract Epilepsy, a prevalent neurological disorder, necessitates precise and reliable electrophysiological recording for accurate study diagnosis. Although traditional stereo‐electroencephalography micro‐wire probes are widely used in epilepsy research, they limited by site numbers mechanical properties. This explores the use of high‐density, ultra‐flexible neural monitoring, highlighting their advantages terms performance, scalability, tissue compatibility. work validates effectiveness...
Flexible Neural Probes The cover image portrays a flexible electrode strategically positioned within the biological brain, surrounded by numerous neurons. These electrodes exhibit natural curvature and torsion in cerebral spinal fluid, highlighting their remarkable flexibility demonstrating high level of biocompatibility. Notably, during epileptic seizures, neurons surrounding continuously transmit signals, interactions ions inside outside cells create distinct electric potentials. intricate...
ASBTARCT Adenoviruses mediated cancer gene therapies are widely investigated and show a promising effect on treatment. However, efficient transfer varies among different cell lines based the expression of coxsakie adenovirus receptor (CAR). Hep27, member dehydrogenase/reductase (SDR) family, can bind to Mdm2, resulting in attenuation Mdm2-mediated p53 degradation. Here we constructed fiber chimeric carrying hep27 (F5/35-ZD55-Hep27), which protein 5-serotype (Ad5) was substituted by that...
ABSTRACTPeach gum was the most common and widely used exudate in ancient China. In this study, polyclonal antibodies to peach were prepared using protein of as antigen. The identify with high sensitivity specificity by biotin–streptavidin-enzyme-linked immunosorbent assay (BA-ELISA). binders paintings Forbidden City Dazu Rock Carvings detected enzyme-linked (ELISA). results showed that diverse, including collagen, ovalbumin, casein, gum, lacquer, collagen coexisted samples City. This study...
Abstract Black glazed wares ( Wujin wares) and hare fur's decorated black (HF are ones of typical production Jian kilns, China during Song Dynasty. In this work, HF excavated in kiln complex (Yulinting Daluhoumen kilns Luhuaping kilns) were systematically analyzed by optical microscope, X‐ray fluorescence spectroscopy micro‐Raman spectroscopy. The results show that the index glassy polymerization (Ip) is smaller than areas wares, indicating higher firing temperature used for wares. Several...
The incidence of intrahepatic cholangiocarcinoma (ICC) is increasing globally, and its prognosis has not improved substantially in recent years. Understanding the pathogenesis ICC may provide a theoretical basis for treatment. In this study, we investigated effects underlying mechanisms fucosyltransferase 5 (FUT5) on malignant progression ICC.FUT5 expression samples adjacent nontumor tissues was compared using quantitative real-time polymerase chain reaction immunohistochemical assays. We...
Esophageal cancer (EC) remains one of the major causes incidence and mortality worldwide. Genetic factors, such as single nucleotide polymorphisms (SNPs), may contribute to carcinogenesis EC.We conducted a hospital based case-control study evaluate genetic susceptibility SNPs on development EC. A total 629 esophageal squamous cell carcinoma (ESCC) cases 686 controls were enrolled for this study. Seven PADI4 determined by ligation detection reaction method.Our findings suggested that...