A5088507691- Hepatitis B Virus Studies
- Hepatitis C virus research
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Hepatitis Viruses Studies and Epidemiology
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Gallbladder and Bile Duct Disorders
- Epigenetics and DNA Methylation
- Pancreatitis Pathology and Treatment
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Inflammatory Bowel Disease
- Renal cell carcinoma treatment
- Colorectal Cancer Screening and Detection
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Helicobacter pylori-related gastroenterology studies
- Pediatric Hepatobiliary Diseases and Treatments
Shenzhen Second People's Hospital
2018-2025
Jinan University
2016-2025
Southern University of Science and Technology
2019-2025
Shanghai Changzheng Hospital
2022-2025
ShenZhen People’s Hospital
2018-2025
University Gastroenterology
2025
First Affiliated Hospital of Henan University of Science and Technology
2025
Guangdong Medical College
2023-2025
The University of Texas MD Anderson Cancer Center
2025
Beike Biotechnology (China)
2025
Plant-derived exosome-like nanoparticles (PDENs) have been paid great attention in the treatment of ulcerative colitis (UC). As a proof concept, we isolated and identified Portulaca oleracea L-derived (PELNs) from edible L, which exhibited desirable nano-size (~ 160 nm) negative zeta potential value (-31.4 mV). Oral administration PELNs effectively suppressed expressions pro-inflammatory cytokines (TNF-α, IL-6, IL-12, IL-1β) myeloperoxidase (MPO), increased levels anti-inflammatory cytokine...
AIM:To determine the therapeutic efficacy of resveratrol on ulcerative colitis (UC) and its underlying mechanisms. METHODS:The mouse UC model was developed using 5% dextran sulfate sodium.Mice were randomly divided into four groups: normal control, group, low-dose group (RLD; 50 mg/kg per day), high-dose (RHD; 100 mg/ kg day). RESULTS:The results showed that RLD regulates Treg/Th17 balance mainly through reducing number Th17 cells, whereas RHD Treg/ both downregulating cells upregulating...
Probiotics have been proposed as a potential strategy for managing ulcerative colitis (UC). However, the underlying mechanisms mediating microbiota-host crosstalk remain largely elusive. Here, we report that Limosilactobacillus reuteri (L. reuteri), probiotic, secretes cytoplasmic membrane vesicles (CMVs) communicate with host cells, alter physiology, and alleviate dextran sulfate sodium (DSS)-induced colitis. First, L. reuteri-CMVs selectively promoted proliferation of beneficial bacterium...
AIM:To examine the effect of farnesoid X receptor (FXR) activation by GW4064 on endotoxin-induced hepatic inflammation in nonalcoholic fatty liver disease (NAFLD) and underlying mechanism. METHODS:Six-week-old male C57BL/6 mice were fed a normal diet or high-fat (HF) for 8 wk.HF dietfed intraperitoneally injected with (30 mg/kg) DMSO (vehicle) once daily week then sacrificed after lipopolysaccharide (LPS, 50 μg/mouse) administration.Hepatic inflammation, levels macrophage marker F4/80,...
Baicalin is a bioactive ingredient extracted from the root of Scutellariae radix, which used to treat ulcerative colitis (UC).We investigated activity baicalin on lipopolysaccharide-stimulated RAW264.7 cells and 2,4,6-trinitrobenzene sulfonic acid-induced rats, including attenuation oxidant stress apoptosis.The severity was assessed by disease index. The activities catalase (CAT), glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), content malondialdehyde (MDA) were determined their...
Tumstatin (Tum) is a powerful angiostatin that inhibits proliferation and induces apoptosis of tumorous vascular endothelial cells. A nonpathogenic anaerobic bacterium, Bifidobacterium longum ( BL), selectively localizes to proliferates in the hypoxia location within solid tumor. The aims this study were develop novel delivery system for Tum using engineered investigate inhibitory effect on tumor mice. vector enabled expression under control pBBADs promoter BL was constructed transformed...
Objective Adequate bowel preparation is essential for a successful colonoscopy; clinical studies suggest reinforced education can improve the process. However, there have been no trials to compare WeChat directions (the most widely used social media app in China) with those of short message service (SMS). This study was aimed assess effect and SMS on quality. Participants methods single-center, prospective, endoscopically blinded, randomized, controlled study. Patients groups received...