A5100690193- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- Hepatocellular Carcinoma Treatment and Prognosis
- Extracellular vesicles in disease
- Bladder and Urothelial Cancer Treatments
- Galectins and Cancer Biology
- Cytokine Signaling Pathways and Interactions
Fudan University
2002-2024
Zhongshan Hospital
2018-2024
Ningbo No. 2 Hospital
2020-2024
Chongqing University
2024
Shanghai Municipal Commission of Health and Family Planning
2023-2024
Zhengzhou Children's Hospital
2015-2024
Zhengzhou University
2006-2024
Sichuan Cancer Hospital
2022-2024
Qinghai University Affiliated Hospital
2024
Hubei Polytechnic University
2024
Sorafenib is a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC), but its clinical effects are still limited. In this study we identify Quiescin sulfhydryl oxidase 1 (QSOX1) acting as cellular pro-oxidant, specifically in the context of sorafenib treatment HCC. QSOX1 disrupts redox homoeostasis and sensitizes HCC cells to oxidative stress by inhibiting activation master antioxidant transcription factor NRF2. A negative correlation between NRF2 expression was...
Tumor-associated macrophages (TAMs), which form a large part of the tumor microenvironment, are normally regulated by metabolic reprogramming. However, potential mechanisms immune-metabolism interaction between hepatocellular carcinoma (HCC) cells and TAMs remain unclear.The candidate long non-coding RNAs (lncRNAs) were screened Smart-seq based scRNA-seq method then validated qPCR. Immunostaining analysis was done to examine levels markers for glycolysis. Exosomes from primary human HCC...
Abstract Background Although an abundance of evidence has indicated that tumor-associated macrophages (TAMs) are associated with a favorable prognosis in patients colon cancer, it is still unknown how TAMs exert protective effect. This study examined whether involved hepatic metastasis cancer. Materials and methods One hundred sixty cases pathologically-confirmed specimens were obtained from carcinoma TNM stage IIIB IV between January 1997 July 2004 at the Cancer Center Sun Yat-Sen...
Hepatocellular carcinoma (HCC) remains one of the most refractory malignancies worldwide. Schlafen family member 11 (SLFN11) has been reported to play an important role in inhibiting production human immunodeficiency virus 1 (HIV-1). However, whether SLFN11 also inhibits hepatitis B (HBV), and affects HBV-induced HCC remain be systematically investigated. Methods: qRT-PCR, western blot immunohistochemical (IHC) staining were conducted investigate potential prognostic value HCC. Then was...
Human papillomavirus (HPV) is a DNA virus that causes sexually transmitted infections.The HPV oncoprotein E7 plays critical role in the regulation of host immunity to promote immune escape and occurrence cervical cancer or genital warts.Pyroptosis, highly inflammatory form programmed cell death, can be induced by inflammasomes acts as defense against pathogenic infection.However, whether regulate pyroptosis evade surveillance has not been determined.In this study, we found could inhibit...
Guanosine triphosphate binding protein 4 (GTPBP4) is a key regulator of cell cycle progression and MAPK activation. However, how its biological properties intersect with cellular metabolism in hepatocellular carcinoma (HCC) development remains poorly unexplained. Here, high GTPBP4 expression found to be significantly associated worse clinical outcomes patients HCC. Moreover, upregulation paralleled by DNA promoter hypomethylation regulated DNMT3A, methyltransferase. Additionally, both gain-...
Background Hepatocellular carcinoma (HCC) is a malignancy with limited treatment options and poor prognosis. Macrophages are enriched in the HCC microenvironment have significant impact on disease progression therapy efficacy. We aim to identify critical macrophages subsets involved development. Methods Macrophage-specific marker genes were identified through single-cell RNA sequencing analyses. The clinical significance of palmitoyl-protein thioesterase 1 (PPT1) positive was investigated...
Within the immune system there is an exquisite ability to discriminate between "self" and "non-self" that orchestrated by T lymphocytes. Discriminatory pathways guide differentiation of these lymphocytes into either regulatory (Treg) or effector (Teff) cells, influenced cues from naïve cell's immediate micro-environment as it responds cognate antigen. Reciprocal may lead commitment cells protective tolerance-promoting Treg, pro-inflammatory Th17 phenotype. Primary activation CD4+ stimulates...
A growing amount of evidence supports that microRNA (miRNA) dysregulation is involved in cancer progression by directly downregulating multiple targets. Elucidating the underlying mechanism miRNA carcinogenesis may improve diagnostic and therapeutic strategies for malignancy. In current study, we found miR-105 expression was markedly downregulated both hepatocellular carcinoma (HCC) cell lines clinical HCC tissues, compared with normal human hepatocyte adjacent non-cancerous respectively....
Rationale: Glioblastoma (GBM) is the most common and aggressive brain tumor, characterized by its propensity to invade surrounding parenchyma. The effect of extracellular high-mobility group box 1 (HMGB1) protein on glioblastoma progression still controversial. p62 overexpressed in glioma cells, has been associated with malignant features poor prognosis GBM patients. Hence, this study aimed clarify role HMGB1-induced epithelial-mesenchymal transition (EMT) both vitro vivo. Methods:...
Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide owing to its high rates metastasis and recurrence. The oncogene IQ motif-containing GTPase activating protein 3 (IQGAP3) ubiquitously overexpressed in several human cancers, including liver, ovary, lung, large intestine, gastric, bone marrow, breast malignancies involved invasion cancer cells. Therefore, we aimed determine biological role molecular mechanism IQGAP3 HCC. We used 120 archived clinical HCC samples, 9...
Involvement of the RGS 17 oncogene in promotion non‐small‐cell lung cancer ( NSCLC ) has been reported, but regulation mechanism remains unclear. Micro RNA s (mi s) negatively regulate gene expression, and their dysregulation implicated tumorigenesis. To understand role mi Regulator G Protein Signaling 17)‐induced , we showed that miR‐203 was downregulated during tumorigenesis, inhibited proliferation invasion cells. We then determined whether regulated by targeting 17. characterize...
Epidermal growth factor-containing fibulin-like extracellular matrix protein 2 (EFEMP2), an protein, is highly associated with tumor invasion and metastasis.However, influenced by the microenvironment, EFEMP2 played different roles in tumors.The current study focused on exploring role of bladder cancer (BCa).The results suggested that expression was significantly higher normal tissues cells compared BCa samples cells.And we found a negative correlation between high stage, grade, patients low...
Cell division cycle associated 8 (CDCA8) overexpression is detected in various malignant tumors and closely with tumor growth. However, the correlations of CDCA8 expression clinicopathological factors prognosis bladder cancer (BC) remain unclear. The purpose this study was to identify its clinical relevance BC patients.GEO datasets were employed obtain data information samples. Real-time PCR (RT-PCR) performed detect adjacent normal tissues. Nonpaired t test used statistically analyze...
Abstract Olfactory ensheathing cells (OECs) are a unique type of macroglia with axonal growth‐promoting properties. The migrating ability OECs in CNS is essential for neural regeneration. However, little known about the extracellular and intracellular factors that regulate OEC migration. In present study, we examined effects glial cell line‐derived neurotrophic factor (GDNF) on Initially, “scratch” migration assay, Boyden chamber explant assay showed GDNF could promote vitro. Treatment also...
Foxp3(+) regulatory T cells (Tregs) express both ectoenzymes CD39 and CD73, which in tandem hydrolyze pericellular ATP into adenosine, an immunoinhibitory molecule that contributes to Treg suppressive function. Using Foxp3GFP knockin mice, we noted the mouse CD4(+)CD39(+) T-cell pool contains two roughly equal size Foxp3(-) populations. While Foxp3(+)CD39(+) are CD73(bright) bone fide Tregs, Foxp3(-)CD39(+) do not have activity CD44(+)CD62L(-)CD25(-)CD73(dim/-), exhibiting memory cell...
To observe the therapeutic effect of different dosages Gegen Qin Lian Decoction on type 2 diabetic patients.Fifty-four patients from low dosage group (20 cases), medium (19 cases) and high (15 were treated with for 12 weeks. Fasting blood-glucose (FBG), postprandial blood sugar (PBG) Hemoglobin A1c (HbA1c) determined before after treatment.With increase dosage, overall effective rate glycaemic control increased, FBG, PBG HbA1c decreased. The glucose 80%, 47%, 30% respectively, there...