Bile acids (BAs) are a group of important physiological agents for cholesterol metabolism, intestinal nutrient absorption, and biliary secretion lipids, toxic metabolites, xenobiotics. Extensive research in the last two decades has unveiled new functions BAs as signaling molecules metabolic regulators that modulate hepatic lipid, glucose, energy homeostasis through activation nuclear receptors G-protein-coupled receptor gut-liver axis involving host-gut microbial co-metabolism. Therefore,...

α‑hederin, a monodesmosidic triterpenoid saponin, had previously demonstrated strong anticancer effects. In the current study, pharmacological mechanism of autophagic cell death induced by α‑hederin was investigated in human colorectal cancer cells. First, through counting kit‑8 and colony formation assays, it that could inhibit proliferation HCT116 HCT8 cell. Results flow cytometry using fluorescein isothiocyanate Annexin V/propidium iodide Hoechst 33258 staining indicated induce apoptosis....

Involvement of the RGS 17 oncogene in promotion non‐small‐cell lung cancer ( NSCLC ) has been reported, but regulation mechanism remains unclear. Micro RNA s (mi s) negatively regulate gene expression, and their dysregulation implicated tumorigenesis. To understand role mi Regulator G Protein Signaling 17)‐induced , we showed that miR‐203 was downregulated during tumorigenesis, inhibited proliferation invasion cells. We then determined whether regulated by targeting 17. characterize...

Abstract BACKGROUND Stevia has been proposed as a potential antidiabetic sweetener, mainly based on inconsistent results from stevioside or the plant extract, yet lacking relative experimental evidence individual steviol glycosides (SGs) and their metabolites. RESULTS The systematically revealed that typical SGs final metabolite (steviol) presented an effect streptozotocin (STZ) diabetic mice in all assayed aspects. In general, performance strength of samples followed sequence > glucosyl...

ObjectiveCytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is a standard treatment for pseudomyxoma peritonei (PMP) recommended by Peritoneal Surface Oncology Group International (PSOGI). The study to analyze the incidence of perioperative serious adverse events (SAEs) CRS + HIPEC treat PMP patients, identify risk factors, guiding prevention SAEs.MethodsThis retrospective on database established at our center. clinicopathological features, details SAEs...

Background: The emergence and wide global spread of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates are great concern, the aim this study was to investigate drug resistance, molecular epidemiology, genetic relationship CRKP from patients in Shanghai, China. Methods: A retrospective conducted April 2018 July 2019, a total 133 were collected. Antimicrobial susceptibility determined by VITEK-2 automated microbiology analyzer platform (bioMérieux, France) broth microdilution method....

Objective . We aimed to explore whether squamous cell carcinoma antigen (SCC), cytokeratin 19 fragment (Cyfra21-1), neuron-specific enolase (NSE), and carcinoembryonic (CEA) are elevated in diabetic nephropathy (DN) the association between urinary albumin-to-creatinine ratio (UACR) tumor markers patients. Methods Nondialysis patients with diabetes (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>261</mml:mn></mml:math>) 90 healthy...

The current study aimed to identify novel long non‑coding RNAs (lncRNAs) associated with gastric cancer (GC). Transcriptome sequencing of the lncRNAs and mRNAs from GC tissues normal adjacent was performed. data were analyzed using bioinformatics analysis, specifically analysis differentially expressed mRNA, target gene prediction functional enrichment analysis. A total 1,181 mRNA 390 identified. targets upregulated significantly enriched in functions collagen fibril organization, whereas...

This study aimed to investigate the antimicrobial susceptibility of Shigella isolated in Shanghai, China and determine genetic basis its resistance fluoroquinolones.A total 402 strains Shigella, including 145 flexneri 257 sonnei isolates, were analyzed. The Kirby-Bauer disk diffusion method was used 13 antimicrobials. Minimum inhibitory concentration ciprofloxacin determined by E-test. Mutations within quinolone resistance-determining regions (QRDRs) gyrA parC plasmid-mediated (PMQR) genes,...

The Glasgow Coma Scale (GCS) is widely used in neurosurgery to evaluate the depth of coma patients with brain injury. bispectral index (BIS) was developed primarily monitor unconsciousness. Recent evidence suggests that BIS may also help assessment This study explores correlation between GCS scores and values injury.Fifty were divided into 2 groups-moderate (GCS 9-12) severe 3-8)-in this prospective, double-blind, observational study. Bispectral data recorded when electromyography less than...

Abstract Background During the COVID − 19 outbreak, limited medical resources in short term and inadequate experience dealing with major new public health events may lead to neglect of some other infectious diseases, such as malaria, leading risk spread diseases.Therefore, it is particularly important formulate classified guidance, take scientific prevention control measures a comprehensive manner, strengthen screening malaria patients provide access treatment during outbreak. Methods...

Background To investigate the association between sex differences and end-stage kidney disease (ESKD) in patients with biopsy-confirmed diabetic (DKD). Method We performed a retrospective cohort study. A total of 336 DKD who were followed up for at least 12 months enrolled. Baseline clinical pathological data time biopsy collected. ESKD was defined by an estimated glomerular filtration rate &amp;lt;15 ml/min/1.73 m 2 or initiation renal replacement therapy. The assessed using log-rank test...

The present study aims to (1) evaluate the autoanalyser quality control (QC) module of Kehua Polaris c2000 automatic modularised biochemical analyser and (2) verify impact analyser's implementation internal QC (IQC) testing at a set time point on results IQC turnaround (TAT). For 5 consecutive days, three different methods were used conduct IQC. Method 1: Internal was carried out 8:00 every day. 2: products placed in instrument calibration plate afternoon, measure 7:00 next day...

Aim To investigate pepsinogen secretion from the neonatal stage to childhood and its diagnostic value for peptic ulcer (PU) in children. Methods In this study, 2114 ‘healthy’ children 51 with PUs undergoing a medical examination by gastroscopy were selected as subjects. The serum content of I (PGI) II (PGII) was tested each subjects using time‐resolved fluorescence immunoassay, which is characterised high sensitivity wide measuring range. Results PGI PGII levels found increase age, becoming...

OBJECTIVE To analyze the clinical and laboratory characteristics of coronavirus disease 2019 (COVID-19) patients with different prognosis, to provide evidence for diagnosis treatment COVID-19. METHODS The 215 cases confirmed COVID-19 admitted in First People's Hospital Tianmen City from January 18 March 10, 2020 were retrospectively analyzed, including blood cell indexes, inflammatory indexes [C-reactive protein (CRP) procalcitonin (PCT)], liver function, cardiac renal coagulation...

Abstract Background: To investigate the association between sex differences and end-stage kidney disease (ESKD) in patients with biopsy-confirmed diabetic (DKD). Method: We performed a retrospective cohort study. A total of 336 DKD who were followed up for at least 12 months enrolled. Baseline clinical pathological data collected. ESKD was defined by an estimated glomerular filtration rate &lt;15 mL/min/1.73m 2 or initiation renal replacement therapy. The assessed using log-rank test Cox...

Objective To analysis the frequency and mutational patterns of HBV (hepatitis B virus) S protein in different phases chronic hepatitis patients, exploring clinical implication these mutations CHB. Methods The difference mutation rates site among each groups were analyzed by cases-comparison. 112 cases patients Shanghai Shu-guang hospital enrolled this study; they divided into four groups, immune-tolerance group [IT, 36 cases, male 20 cases,female 16 cases,age 28.00...

Abstract Objective : This study aimed to investigate the feasibility of applying defect-size polyether ether ketone (PEEK) implant for treatment localized osteochondral defects in femoral head and compared it with cobalt chromium molybdenum (CoCrMo) alloy implant. Methods A defect model was created left hips goats (n=12). Defects were randomly treated by immediate placement a PEEK (n=6) or CoCrMo (n=6). The un-operated right hip joints served as control. Goats sacrificed at 12 weeks....