A5053576258- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Nitrogen and Sulfur Effects on Brassica
- Natural product bioactivities and synthesis
- Medical Imaging Techniques and Applications
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Complexity and Algorithms in Graphs
- Optimization and Packing Problems
- Cancer, Hypoxia, and Metabolism
- Optimization and Search Problems
- Genomics, phytochemicals, and oxidative stress
- Spinal Cord Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Bioactive Compounds and Antitumor Agents
- Healthcare and Venom Research
- GDF15 and Related Biomarkers
- Advanced Glycation End Products research
- Advanced SAR Imaging Techniques
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
Shanghai University of Medicine and Health Sciences
2019-2025
Shanghai University of Traditional Chinese Medicine
2019-2025
Beijing Forestry University
2024
Jiading District Central Hospital
2022-2024
Beihang University
2023-2024
Huazhong University of Science and Technology
2022-2024
Wenzhou Medical University
2024
University of Shanghai for Science and Technology
2021-2023
Tongji University
2023
Zhengzhou University
2023
Background/Aims: Recent studies have indicated that exosomes secreted from adipose-derived stem cells (ADSCs) important effects in the treatment of ischemic injury. However, mechanism is unclear. This study aimed to investigate whether ADSC-derived enriched with microRNA (miR)-30d-5p a protective effect on acute stroke (AIS). Methods: In current study, inflammatory factors and miR-30d-5p expression were assessed 70 subjects AIS 35 healthy controls. Exosomes characterized by transmission...
Recent studies have indicated that exosomes play an important role in adipose-derived stem cell (ADSC) transplant-mediated ischaemic heart disease therapy. However, the treatment effect is not obvious. The aim of this study to investigate whether ADSC-derived enriched with microRNA (miR)-126 a more protective on acute myocardial infarction (AMI).Exosomes were characterized by transmission electron microscopy, and exosome particles further examined using nanoparticle tracking analyses. A rat...
Abstract Background Long non-coding RNAs (lncRNAs) have been associated with non-small cell lung cancer (NSCLC), but the underlying molecular mechanisms of their specific roles in mediating aerobic glycolysis poorly explored. Methods Next-generation RNA sequencing assay was performed to identify differentially expressed between NSCLC tissues high 18 F-fluorodeoxyglucose (FDG) uptake and adjacent normal tissues. LINC01123 expression measured by real-time PCR situ hybridization (ISH) assay....
Adipose-derived stromal cells (ADSCs) have been considered as an attractive therapeutic tool. Accumulating evidence indicates that the healing effects of ADSCs are mainly related to paracrine action rather than transdifferentiation. Data show expression miR-93-5p has a cardio-protective effect after acute myocardial infarction (AMI). To identify whether miR-93-5p-encapsulating exosomes form better effect, we investigated inflammatory factors and miR-30d-5p in clinical levels. A rat model AMI...
Hypoxia is commonly observed in solid tumors and contributes to the resistance of DNA damage drugs. However, mechanisms behind this are still unclear. In study, we aimed explore effects hypoxia-induced exosomes on non-small cell lung cancer (NSCLC). Methods: NSCLC cells were subjected either normoxic or hypoxic conditions assess survival changes expression levels key proteins. Comparative proteomics performed identify exosomal PKM2 cisplatin-resistant cells-derived exosomes. Functions...
Acute ischemic stroke (AIS) is the most common type of cerebrovascular disease and a leading cause disability death worldwide. Recently, study suggested that transformation microglia from pro-inflammatory M1 state to anti-inflammatory tissue-reparative M2 phenotype may be an effective therapeutic strategy for stroke. Celastrol, traditional oriental medicine, have neuroprotective effects. However, underlying mechanisms remain unknown. We first determined expression levels inflammatory factors...
Solasonine is a compound isolated from Solanum melongena that has anti-infection properties, and promotes neurogenesis. However, the use of solasonine for treatment hepatocellular carcinoma (HCC) not yet been reported. So, aim this study was to assess efficacy HCC. The effects were tested using HCC cell lines HepG2 HepRG. Metabolomics analysis conducted on tumor growth nude mice xenografts cells. data demonstrated significantly suppressed proliferation HepRG A mouse xenograft model formation...
Circular RNAs (circRNAs) have an important function in human diseases, especially cancer. circRNA hsa_circ_0014130 (circPIP5K1A), a particularly abundant circRNA, participates the tumorigenesis of non-small cell lung cancer (NSCLC), although underlying regulatory mechanism remains unclear. Here, we investigated circPIP5K1A role NSCLC. Expression NSCLC lines was explored with quantitative real-time PCR. The effect on evaluated silencing, miR-600 mimic transfection, and hypoxia-inducible...
The active ingredient of the traditional Chinese medicine comfrey is shikonin, a naphthoquinone compound. focus this study was to investigate effect shikonin on proliferation, invasion, migration, and chemoresistance non-small cell lung cancer (NSCLC) cells, explore its underlying molecular biological mechanisms. results show that inhibited viability, migration NSCLC cells A549 PC9, induced apoptosis. As inhibitor pyruvate kinase M2 (PKM2), key enzyme in glycolysis, glucose uptake production...
Background: Hypoxia plays an important role in the lung metastasis of hepatocellular carcinoma (HCC). However, process by which hypoxia promotes formation a pre-metastatic niche (PMN) and its underlying mechanism remain unclear. Methods: Exosomes derived from normoxic hypoxic HCC cells were collected to induce fibroblast activation vitro PMN vivo. The micro RNA (miR) profiles exosomes sequenced identify differentially expressed miRNAs. Gain- loss-of-function analyses performed investigate...
Abstract Intercellular communication often relies on exosomes as messengers and is critical for cancer metastasis in hypoxic tumor microenvironment. Some circular RNAs (circRNAs) are enriched cell‐derived exosomes, but little known about their ability to regulate intercellular metastasis. Here, by systematically analyzing secreted non‐small cell lung (NSCLC) cells, a hypoxia‐induced exosomal circPLEKHM1 identified that drives NSCLC through polarizing macrophages toward M2 type....
Non-small-cell lung cancer (NSCLC) is one of the deadliest cancers in world. Circular RNA (circRNA) has been shown to participate oncogenesis regulation, including cancer. Although involvement circRNAs reported, regulatory mechanisms NSCLC remain poorly understood. Thus, present study aims at investigating role circARHGAP10 progression, which observed be significantly upregulated both tissues and cell lines with profile analysis. A higher expression also leads a poor prognosis patients...
The circular RNA RAPGEF5 (circRAPGEF5) is generated from five exons of the gene and abnormal expression in papillary thyroid cancer (PTC). However, whether circRAPGEF5 plays a role PTC tumorigenesis remains unclear. aim present study was to investigate PTC. results showed that upregulated tissues cell lines. knockdown inhibited proliferation, migration, invasion vitro; silencing downregulated fibroblast growth factor receptor 1 (FGFR1) by "sponging" miR-198, suppressing aggressive biological...
Alzheimer's disease (AD) is the most common dementia in world. Increasing evidence has shown that exosomes from hypoxic pretreated adipose-derived stem cells (ADSCs) could be an effective cognitive function therapeutic AD-associated pathophysiology. However, their role and regulatory mechanism remain largely unknown. High-throughput sequencing was used to identify differentially expressed circRNAs ADSCs or hypoxia ADSC exosomes. Luciferase reporter assays RT-qPCR were investigate...
Involvement of the RGS 17 oncogene in promotion non‐small‐cell lung cancer ( NSCLC ) has been reported, but regulation mechanism remains unclear. Micro RNA s (mi s) negatively regulate gene expression, and their dysregulation implicated tumorigenesis. To understand role mi Regulator G Protein Signaling 17)‐induced , we showed that miR‐203 was downregulated during tumorigenesis, inhibited proliferation invasion cells. We then determined whether regulated by targeting 17. characterize...
Acetaminophen (APAP) overdose is the main cause of acute liver failure. Apigenin (API) a natural dietary flavonol with high antioxidant capacity. Herein, we investigated protection by API against APAP-induced injury in mice, and explored potential mechanism. Cell viability assays mice were used to evaluate effects injury. Western blotting, immunofluorescence staining, RT-PCR, Transmission Electron Microscope carried out determine signalling pathways affected API. Analysis mouse serum levels...
Emerging studies showed that α-hederin induced autophagic cell death in different cancers via reactive oxygen species. Nevertheless, role non-small-cell lung cancer (NSCLC) remains unknown. So, the aim of this study was to explain whether ferroptosis is a therapeutic strategy NSCLC, and explore effect on NSCLC ferroptosis. Current investigation found inhibited proliferation, invasion, migration vitro vivo at toxic doses. The treatment also increased chemosensitivity cisplatin promoted...
Ginsenoside Rh2 (G-Rh2), a steroidal compound extracted from roots of ginseng, has been extensively studied in tumor therapy. However, its specific regulatory mechanism non-small cell lung cancer (NSCLC) is not well understood. Pyruvate dehydrogenase kinase 4 (PDK4), central regulator cellular energy metabolism, highly expressed various malignant tumors. We investigated the impact G-Rh2 on progression NSCLC and how it regulated PDK4 to influence aerobic glycolysis mitochondrial function.
Background: Lung cancer (LC) is the second most lethal and efficient treatments are missing. Our understanding of underlying pathogenic mechanisms remains limited. Oridonin a compound extracted from Chinese herb Rabdosia rubescens with anticancer properties. Nevertheless, its effects on LC remain unknown. Methods: In current research, A549 Hcc1833 cells were treated different doses oridonin, cell proliferation migration detected using CCK8, EdU, Transwell, wound healing assays. A...
Introduction: Non-small cell lung cancer (NSCLC) is a lethal type of (LC) with 5-year survival rate 19%. Because drug resistance typically develops following chemotherapy, radiotherapy, and immunotherapy, novel NSCLC therapeutic strategy urgently demanded. Gambogenic acid (GNA), major bioactive ingredient isolated from gamboge, has multipotent antitumor effects, although activity against unknown. Methods: CCK8, ethynyl deoxyuridine (EdU), the plate colony formation assay, transwell wound...