A5100673293- Medicinal Plant Pharmacodynamics Research
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Natural product bioactivities and synthesis
- Immune cells in cancer
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Phytochemical compounds biological activities
- Retinal Diseases and Treatments
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Bioactive Compounds and Antitumor Agents
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Angiogenesis and VEGF in Cancer
- Traditional Chinese Medicine Analysis
- Garlic and Onion Studies
- Nanoplatforms for cancer theranostics
- Mast cells and histamine
- Invertebrate Immune Response Mechanisms
- interferon and immune responses
- Calcium signaling and nucleotide metabolism
- Aquaculture disease management and microbiota
Nanjing University of Chinese Medicine
2016-2025
Jiangsu Provincial Academy of Traditional Chinese Medicine
2016-2025
Guangdong Academy of Agricultural Sciences
2024
Qingdao Agricultural University
2024
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2023
University of Electronic Science and Technology of China
2022-2023
Hebei Academy of Agriculture and Forestry Sciences
2022
Guangzhou Medical University
2022
Beijing University of Chinese Medicine
2022
East China University of Science and Technology
2020
Background Migration and invasion are two crucial steps of tumor metastasis. Blockage these may be an effective strategy to reduce the risk. The objective present study was investigate effects diallyl trisulfide (DATS), a natural organosulfuric compound with most sulfur atoms found in garlic, on migration triple negative breast cancer (TNBC) cells. Molecular mechanisms underlying anticancer DATS were further investigated. Methods Results MDA-MB-231 cells HS 578t treated different...
The active ingredient of the traditional Chinese medicine comfrey is shikonin, a naphthoquinone compound. focus this study was to investigate effect shikonin on proliferation, invasion, migration, and chemoresistance non-small cell lung cancer (NSCLC) cells, explore its underlying molecular biological mechanisms. results show that inhibited viability, migration NSCLC cells A549 PC9, induced apoptosis. As inhibitor pyruvate kinase M2 (PKM2), key enzyme in glycolysis, glucose uptake production...
Abstract Sustainable retinal codelivery poses significant challenges technically, although it is imperative for synergistic treatment of wet age‐related macular degeneration (wAMD). Here, a microemulsion‐doped hydrogel (Bor/PT‐M@TRG) engineered as an intravitreal depot composing temperature‐responsive (TRG) and borneol‐decorated paeoniflorin (PF) & tetramethylpyrazine (TMP)‐coloaded microemulsions (Bor/PT‐M). Bor/PT‐M@TRG, functioning the “ammunition depot”, resides in vitreous...
Intratumoral hypoxia promotes the distant metastasis of cancer subclones. The clinical expression level hypoxia‐inducible factor‐1α (HIF‐1α) reflects prognosis a variety cancers, especially breast cancer. Histone deacetylase (HDAC) inhibitors can target HIF‐1α protein due to von Hippel‐Lindau (VHL) protein‐dependent degradation. Dietary organosulfur compounds, such as those in garlic, have been reported HDAC inhibitors. effects diallyl sulfide (DAS), disulfide (DADS), and trisulfide (DATS)...
Cancer-associated fibroblasts (CAFs) deteriorate tumor microenvironment (TME) and hinder intra-tumoral drug delivery. Direct depleting CAFs exists unpredictable risks of metastasis. Epithelial-mesenchymal transition (EMT) is a critical process converted from hepatic stellate cells during hepatocellular tumorigenesis; however, until now the feasibility reversing EMT to battle carcinoma has not been comprehensively explored. In this study, we report CFH peptide (CFHKHKSPALSPVGGG)-decorated...
Programmed cell death protein 1 (PD-1) inhibitors are the most common immune-checkpoint and considered promising drugs for hepatocellular carcinoma (HCC). However, in clinical settings, they have a low objective response rate (15%–20%) patients with HCC; this is because of insufficient level activity tumor-infiltrating T lymphocytes (TILs). The combined administration oxymatrine (Om) astragaloside IV (As) can increase levels TILs by inhibiting activation cancer-associated fibroblasts (CAFs)...
Microsatellite-stable colorectal cancer (MSS-CRC) exhibits resistance to programmed cell death protein-1 (PD-1) therapy. Improving the infiltration and tumor recognition of cytotoxic T-lymphocytes (CTLs) is a promising strategy, but it encounters huge challenges from drug delivery mechanisms aspects. Here, zeolitic imidazolate framework (ZIF) coated with apoptotic body membranes derived MSS-CRC cells engineered for co-delivery ginsenoside Rg1 (Rg1) atractylenolide-I (Att) MSS-CRC, named as...
Sustained retina drug delivery and rational combination are considered essential for enhancing the efficacy of therapy wet age-related macular degeneration (wAMD) due to conservative structure posterior ocular segment multi-factorial pathological mechanism. Designing a co-delivery system that can simultaneously achieve deep penetration long-lasting retention in vitreous is highly desired, yet remains huge challenge. In this study, we fabricated Bor/RB-M@TRG as an intravitreal-injectable...
Abstract The insufficient abundance and weak activity of tumour-infiltrating lymphocytes (TILs) are two important reasons for the poor efficacy PD-1 inhibitors in hepatocellular carcinoma (HCC) treatment. combined administration tanshinone II A (TSA) astragaloside IV (As) can up-regulate TILs by normalising tumour blood vessels reducing levels immunosuppressive factors respectively. For enhancing antibody, a magnetic metal–organic framework (MOF) with homologous cell membrane (Hm) coating...
The response rate of programmed cell death protein-1 (PD-1) inhibitors in breast cancer remains unsatisfactory, primarily due to the limited infiltration and activity tumor-infiltrating T lymphocytes (TILs). Previous studies demonstrated that oxymatrine (Om) astragaloside IV (As) could enhance TIL function by inhibiting cancer-associated fibroblasts (CAFs) promoting mitochondrial TILs, respectively. Thus, combining Om As may be a promising strategy improve antitumor effects PD-1 cancer....
The aim of this study is to demonstrate the enhanced therapeutic efficacy anticancer drugs on drug-resistant breast cancer using multicomponent microemulsions (ECG-MEs) as an oral delivery system. etoposide-loaded ECG-MEs were composed coix seed oil and ginsenoside Rh2 (G-Rh2), both which possess not only synergistic antitumor effect with etoposide, but also have excipient-like properties. Orally administrated demonstrated be able accumulate at tumor site following crossing intestines intact...
A codelivery system that sequentially releases its contents is an effective strategy to enhance anticancer efficacy.
Cryptotanshinone (CPT), a fat-soluble phenanthraquinone from Salvia miltiorrhiza Bunge, has been demonstrated to inhibit phosphorylation of p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E binding protein (4E-BP1), couple direct downstream effectors the mammalian target rapamycin complex (mTORC1), resulting in cancer cell arrested G0 phase subsequent inhibition proliferation. However, its concrete molecular mechanism about how CPT inhibits mTORC1 signaling pathway is unclear. one...
The adaptive immune system plays an important role in defending against different kinds of diseases, including infection and cancer. There has been a longtime need for simple method to quantitatively evaluate the potency immunity our bodies. tremendously diversified T-cell receptor (TCR) repertoires are foundation system. In this study, we analyzed expressed TCRβ peripheral blood 582 healthy donors 60 cancer patients. TCR repertoire each individual is different, with usages Vβ Jβ genes....
Human uridine-5′-diphosphoglucuronosyltransferases (UGTs) are the major phase II metabolizing enzymes. In present study, five human UGTs (UGT1A1, 1A4, 1A6, 2B7, and 2B10) were individually expressed used to examine inhibition IC50 values of 20 selective substrates inhibitors cytochromes P450 (CYPs). The kinetics UGT1A1 was also analyzed. results showed that some compounds like α-naphthoflavone, paclitaxel, midazolam, cyclosporine A, ketoconazole displayed strong inhibitions on UGT activities...
Cryptotanshinone (CPT) has been demonstrated to inhibit proliferation and mammalian target of rapamycin (mTOR) pathway in MCF-7 breast cancer cells. However, the same results are unable be repeated MDA-MB-231 Given main difference oestrogen receptor α (ERα) between two types cells, It is possibly suggested that CPT inhibits mTOR dependent on ERα cancer. could significantly cell ERα-positive whereas ERα-negative cells insensitive CPT. The molecular docking indicated a high affinity with ERα,...
The aim of this study is to explore the influence Ganoderma lucidum-derived polysaccharides (GLP) coix oil-based microemulsion on pharmaceutical performance and anti-lung cancer treatment. GLP-integrated (MEs(PS-GLP)) exhibited a clear spherical shape, small particle size, good hydrodynamics similar microemulsion, but showed lower zeta potential better stability. Fluorescence resonance energy transfer analysis presented that GLP was integrated with as single system. Notably, average...