A5102850498- Phytochemistry and Biological Activities
- Bioactive natural compounds
- Natural product bioactivities and synthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Adipokines, Inflammation, and Metabolic Diseases
- Phytoestrogen effects and research
- Immunotherapy and Immune Responses
- Chromatography in Natural Products
- Neurological Disease Mechanisms and Treatments
- Mesenchymal stem cell research
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Alzheimer's disease research and treatments
- Retinoids in leukemia and cellular processes
- Soybean genetics and cultivation
- Advanced Glycation End Products research
- Mangiferin and Mango Extracts
- Traditional Chinese Medicine Analysis
- Diabetes and associated disorders
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- Biological and pharmacological studies of plants
- Metal-Organic Frameworks: Synthesis and Applications
Nanjing University of Chinese Medicine
2024
Jiangsu Provincial Academy of Traditional Chinese Medicine
2024
China Pharmaceutical University
2010-2022
Fujian Provincial Hospital
2021
Yunnan University
2020
Peking University People's Hospital
2004-2017
Peking University
2004-2017
Center for Life Sciences
2015
Wan Fang Hospital
2013
The disruption of the blood-brain barrier (BBB) plays a critical role in pathology ischemic stroke. p75 neurotrophin receptor (p75NTR ) contributes to blood-retinal retinal ischemia. However, whether p75NTR influences BBB permeability after acute cerebral ischemia remains unknown. present study investigated and underlying mechanism on integrity an stroke mouse model, middle artery occlusion (MCAO). After 24 h MCAO, astrocytes endothelial cells infarct-affected brain area up-regulated ....
Microsatellite-stable colorectal cancer (MSS-CRC) exhibits resistance to programmed cell death protein-1 (PD-1) therapy. Improving the infiltration and tumor recognition of cytotoxic T-lymphocytes (CTLs) is a promising strategy, but it encounters huge challenges from drug delivery mechanisms aspects. Here, zeolitic imidazolate framework (ZIF) coated with apoptotic body membranes derived MSS-CRC cells engineered for co-delivery ginsenoside Rg1 (Rg1) atractylenolide-I (Att) MSS-CRC, named as...
Abstract The insufficient abundance and weak activity of tumour-infiltrating lymphocytes (TILs) are two important reasons for the poor efficacy PD-1 inhibitors in hepatocellular carcinoma (HCC) treatment. combined administration tanshinone II A (TSA) astragaloside IV (As) can up-regulate TILs by normalising tumour blood vessels reducing levels immunosuppressive factors respectively. For enhancing antibody, a magnetic metal–organic framework (MOF) with homologous cell membrane (Hm) coating...
Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria thomsonii Benth. Although its anti-inflammatory and anti-hyperglycosemia effects have been well documented, effect tectorigenin on endothelial dysfunction insulin resistance involved has not yet reported. Herein, this study aims to investigate action amelioration in endothelium. Palmitic acid (PA) was chosen as stimulant induce ROS production cells successfully established evidenced by specific...
Alzheimer's disease (AD) is characterized by the progressive accumulation of β-amyloid (Aβ)-containing amyloid plaques, and microglia play a critical role in mediating Aβ clearance. Mounting evidence has confirmed that ability clearing decreased with aging AD progress, but underlying mechanisms are unclear. Previously, we have demonstrated Nogo receptor (NgR), for three axon growth inhibitors associated myelin, can decrease adhesion migration to fibrils aging. However, whether NgR expressed...
Two new compounds, 5-methoxy-3′,4′-dihydroxy-6,7-methylenedioxy-4H-1-benzo-pyran-4-one(iriskashmirianin A) (1) and 5,3′-dihydroxy-3-(4′-β-d-glucopyranosyl)-6,7-methylenedioxy-4H-1-benzo-pyran-4-one (germanaism H) (2), along with eight known compounds (3–10), were isolated from the rhizomes of Iris germanica L. The cytotoxicities these tested using Ehrlich's ascites carcinoma (EAC) cancer cell line by 3-(4, 5-dimethylthiazole-2-yl)-2, 5-diphenyltetrazoli-umbromide (MTT) ATP assays. results...
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been established as an effective treatment for patients with hematological malignancies. Disease relapse remains a major cause of transplant failure. T homeostasis is critical to determine the potency GVT effect. Recent studies have shown association CTLA-4 polymorphisms outcome after HLA-identical sibling allogeneic HSCT.In this study, we focused on four polymorphisms, and analyzed impact donor genotypes haplotypes...
Abstract Epigenetic diversity could play an important role in adaptive evolution of organisms, especially for plant species occurring new and stressful environments. Thlaspi arvense (field pennycress), a valuable oilseed crop, is widespread temperate regions the northern hemisphere. In this study, we investigated effect salinity stress on epigenetic variation DNA methylation memory pennycress using methylation‐sensitive amplification polymorphism (MSAP) markers. We examined how status...
The whole plant of Viola yedoensis Makino is used for the treatment of rhinitis, rheumatism, mastitis and acute pyogenic infections. A simple accurate HPLC-UV method was developed simultaneous determination six major constituents in ofV. yedoensis, comparison between its constituent profile eight other species genus Viola investigated. optimal chromatographic conditions were achieved on a Hedera ODS-2 (250 mm×4.6 mm, i.d. 5 μm) column with gradient elution using 0.4% acetic acid aqueous...
Preferentially expressed antigen of melanoma (PRAME), a tumor-associated antigen, is overexpressed in variety hematologic malignancies with great variation expression. The majority patients acute myeloid leukemia (AML) 1-eight-twenty one (ETO)+ AML and certain number myelodysplastic syndromes (MDS) have an abnormally high increase PRAME expression level. landscape methylation requires evaluation order to determine the most relevant sites exact association its level type disease. In present...
<title>Abstract</title> The insufficient abundance and weak activity of tumour-infiltrating lymphocytes (TILs) are two important reasons for the poor efficacy PD-1 inhibitors in hepatocellular carcinoma (HCC) treatment. combined administration tanshinone Ⅱ<sub>A</sub>(TSA) astragaloside IV (As) can up-regulate TILs by normalising tumour blood vessels reducing levels immunosuppressive factors respectively. For enhancing antibody, a magnetic metal–organic framework (MOF) with homologous cell...