A5074742106- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Advanced Drug Delivery Systems
- Cancer Cells and Metastasis
- Supramolecular Self-Assembly in Materials
- Wound Healing and Treatments
- Cutaneous Melanoma Detection and Management
- Acute Ischemic Stroke Management
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Lipid Membrane Structure and Behavior
- Drug Transport and Resistance Mechanisms
- Atrial Fibrillation Management and Outcomes
- Neurological Disease Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- Dendrimers and Hyperbranched Polymers
- Glycosylation and Glycoproteins Research
- Surgical site infection prevention
- Melanoma and MAPK Pathways
- Advancements in Transdermal Drug Delivery
- Pancreatic function and diabetes
- Hydrogels: synthesis, properties, applications
Capital Medical University
2023-2025
Southwest Minzu University
2022-2025
China Pharmaceutical University
2015-2024
State Key Laboratory of Natural Medicine
2015-2024
Nanjing Drum Tower Hospital
2016-2024
Nanjing Medical University
2014-2024
Huazhong University of Science and Technology
2017-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Advanced Pharma
2017-2020
Zhejiang University
2020
Cancer-associated stimuli-responsive nanosystems have been increasingly considered for the delivery of anticancer drugs, which primarily target tumor microenvironment and/or intracellular elements to enhance intratumoral accumulation and promote drug release at site. The signals facilitating include endocytic acidities, hypoxia, enzyme overexpression, as well high levels glutathione, reactive oxygen species, adenosine-5′-triphosphate. This article reviews current techniques ongoing...
A bioinspired cocoon-like anticancer drug delivery system consisting of a deoxyribonuclease (DNase)-degradable DNA nanoclew (NCl) embedded with an acid-responsive DNase I nanocapsule (NCa) was developed for targeted cancer treatment. The NCl assembled from long-chain single-stranded synthesized by rolling-circle amplification (RCA). Multiple GC-pair sequences were integrated into the enhanced loading capacity doxorubicin (DOX). Meanwhile, negatively charged encapsulated in positively...
A programmed drug‐delivery system that can transport different anticancer therapeutics to their distinct targets holds vast promise for cancer treatment. Herein, a core–shell‐based “nanodepot” consisting of liposomal core and crosslinked‐gel shell (designated Gelipo) is developed the sequential site‐specific delivery (SSSD) tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) doxorubicin (Dox). As small‐molecule drug intercalating nuclear DNA, Dox loaded in aqueous liposome, while...
Zwitterionic oligopeptide liposomes (HHG2C18-L) containing a smart lipid (1,5-dioctadecyl-L-glutamyl 2-histidyl-hexahydrobenzoic acid, HHG2C18) are developed to overcome the barriers faced by anticancer drugs on route from site of injection into body final antitumor target within transport steps with multiple physiological and biological barriers. HHG2C18-L show multistage pH-responsive tumor cell (the mitochondria in this case). Their pH response leads more effective entry cell, improved...
Topical administration of anticancer drugs provides a potential chemotherapeutic modality with high patient compliance for cutaneous melanoma. However, the drug delivery efficiency is highly limited by physiological barriers from skin to tumor, which cannot acquire desired therapeutic efficacy. Herein, we propose paintable oligopeptide hydrogel containing paclitaxel (PTX)-encapsulated cell-penetrating-peptide (CPP)-modified transfersomes (PTX-CTs) enhance transdermal PTX topical melanoma...
Abstract To achieve deep tumor penetration of large‐sized nanoparticles (NPs), we have developed a reversible swelling–shrinking nanogel in response to pH variation for sequential intra‐intercellular NP delivery. The had crosslinked polyelectrolyte core, consisting N ‐lysinal‐ ′‐succinyl chitosan and poly( ‐isopropylacrylamide), bovine serum albumin shell, which was able swell an acidic environment shrink back under neutral conditions. swelling resulted rapid release the encapsulated...
A cellular protease (furin)-mediated graphene-based nanosystem is developed for co-delivery of a membrane-associated cytokine (tumor-necrosis-factor-related apoptosis-inducing ligand, TRAIL) and an intracellular-acting small-molecule drug (Doxorubicin, DOX). TRAIL DOX can be sequentially released toward the plasma membrane nucleus, respectively.
Abstract A liposome‐based co‐delivery system composed of a fusogenic liposome encapsulating ATP‐responsive elements with chemotherapeutics and containing ATP was developed for ATP‐mediated drug release triggered by liposomal fusion. The had protein–DNA complex core an DNA scaffold doxorubicin (DOX) could DOX through conformational change from the duplex to aptamer/ATP in presence ATP. cell‐penetrating peptide‐modified membrane coated on core, which acid‐triggered potential ATP‐loaded...
Cancer vaccines show huge potential for cancer prevention and treatment. However, their efficacy remains limited due to weak immunogenicity regarding inefficient stimulation of cytotoxic T lymphocyte (CTL) responses. Inspired by the unique characteristic biological function high-density lipoprotein (HDL), we here develop an HDL-mimicking nanovaccine with commendable lymph-targeted capacity potently elicit antitumor immunity using lipid nanoparticle that is co-loaded specific cytomembrane...
A new glucose-responsive formulation for self-regulated insulin delivery was constructed by packing insulin, glucose-specific enzymes into pH-sensitive polymersome-based nanovesicles assembled a diblock copolymer. Glucose can passively transport across the bilayer membrane of nanovesicle and be oxidized gluconic acid glucose oxidase, thereby causing decrease in local pH. The acidic microenvironment causes hydrolysis pH sensitive that turn triggers release responsive fashion. In vitro studies...
Abstract Recent interest in the control of bone metabolism has focused on a specialized subset CD31 hi endomucin vessels, which are reported to couple angiogenesis with osteogenesis. However, underlying mechanisms that link these processes together remain largely undefined. Here we show zinc-finger transcription factor ZEB1 is predominantly expressed endothelium human and mouse bone. Endothelial cell-specific deletion mice impairs vessel formation bone, resulting reduced Mechanistically,...
A novel "collaborative assembly" approach was reported for the synthesis of an siRNA delivery system via a combination electrostatically driven physical assembly and facile click reaction-mediated chemical assembly, which showed various advantages more safety, efficiency, flexibility over conventional that is only based on assembly. This strategy remained high cationic property lipid-based complex loading capacity. The direct modification model polyanion, hyaluronic acid (HA) chemistry...
Abstract Development of a safe and effective carrier for systemic protein delivery is highly desirable, which depends on management the relationship among loading capacity, stability, efficiency, degradability. Here, tumor‐specific self‐degradable nanogel composed hyaluronidase (HAase)‐degradable hyaluronic acid (HA) matrices entrapping acid‐activatable HAase (aHAase) anticancer proteins reported. Collaboratively crosslinked nanogels (cNG) obtained by synthetic cholesteryl methacrylated HA...
Abstract Chemotherapeutics remain the first choice for advanced gastric cancers (GCs). However, drug resistance and unavoidable severe toxicity lead to chemotherapy failure poor prognosis. Long noncoding RNAs (lncRNAs) play critical roles in tumor progression many cancers, including GC. Here, through RNA screening, an apoptotic protease‐activating factor 1 (APAF1)‐binding lncRNA (ABL) that is significantly elevated cancerous GC tissues independent prognostic patients identified. Moreover,...