A5100386253- Genetic Neurodegenerative Diseases
- Microtubule and mitosis dynamics
- Immune cells in cancer
- Functional Brain Connectivity Studies
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Bacterial Infections and Vaccines
- Immunotherapy and Immune Responses
- Peroxisome Proliferator-Activated Receptors
- Parkinson's Disease Mechanisms and Treatments
- Ubiquitin and proteasome pathways
- Bacteriophages and microbial interactions
- Antimicrobial Peptides and Activities
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- RNA modifications and cancer
- Bacterial Genetics and Biotechnology
- Plant Gene Expression Analysis
- Antimicrobial Resistance in Staphylococcus
- Immune Cell Function and Interaction
- DNA Repair Mechanisms
University of Minnesota
2016-2025
University of Minnesota System
2022-2025
Tianjin Children's Hospital
2025
Tianjin University
2025
Shanghai University
2023-2025
Pittsburgh Supercomputing Center
2017-2024
MRC Weatherall Institute of Molecular Medicine
2024
University of Oxford
2010-2024
Eloxx Pharmaceuticals (United States)
2024
Fudan University
2022-2024
Subcortical dopamine D2 receptor (DRD2) signaling is implicated in cognitive processes and brain disorders, but the effect of DRD2 variants remains ambiguous. We measured allelic mRNA expression postmortem human striatum prefrontal cortex then performed single nucleotide polymorphism (SNP) scans locus. A previously uncharacterized promoter SNP (rs12364283) located a conserved suppressor region was associated with enhanced expression, whereas studied failed to affect expression. Moreover, two...
Our purpose is to identify cancer patients at highest risk of suicide compared the general population and other patients. This a retrospective, population-based study using nationally representative data from Surveillance, Epidemiology, End Results program, 1973-2014. Among 8,651,569 patients, 13,311 committed suicide; rate was 28.58/ 100,000-person years, standardized mortality ratio (SMR) 4.44 (95% CI, 4.33, 4.55). The predominant who were male (83%) white (92%). Cancers lung, head neck,...
There is growing consensus that intervention and treatment of Huntington disease (HD) should occur at the earliest stage possible. Various early-intervention methods for this fatal neurodegenerative have been identified, but preventive clinical trials HD are limited by a lack knowledge natural history dearth appropriate outcome measures. Objectives current study to document premanifest progression in largest cohort ever studied develop battery imaging markers can be used as measures trials....
Colorectal cancer (CRC) is one of the most common malignant tumors and associated with Fusobacterium nucleatum (F. nucleatum, Fn) infection. In this study, we explored role F. in CRC metastasis. Our results showed that abundance was enriched feces patients tended to increase stage IV compared I metastatic CRC. Tumor-derived CCL20 activated by not only increases metastasis, but also participates reprograming tumor microenvironment. promoted macrophage infiltration through activation...
Cancer vaccines show huge potential for cancer prevention and treatment. However, their efficacy remains limited due to weak immunogenicity regarding inefficient stimulation of cytotoxic T lymphocyte (CTL) responses. Inspired by the unique characteristic biological function high-density lipoprotein (HDL), we here develop an HDL-mimicking nanovaccine with commendable lymph-targeted capacity potently elicit antitumor immunity using lipid nanoparticle that is co-loaded specific cytomembrane...
Although it is well accepted that bone tissue metabolism regulated by external mechanical loads, remains unclear to what load-induced physical signals cells respond. In this study, a novel computer-controlled stretch device and parallel plate flow chamber were employed investigate cytosolic calcium Ca2+i mobilization in response range of dynamic substrate strain levels (0.1–10 percent, 1 Hz) oscillating fluid (2 N/m2, Hz). addition, we quantified the effect on expression mRNA for matrix...
A novel antigen that induces cross-reactive bactericidal antibodies against a number of Neisseria meningitidis strains is described. This antigen, approximately 28-kDa lipoprotein called LP2086, was first observed within complex mixture soluble outer membrane proteins (sOMPs) following series fractionation, protein purification, and proteomics steps. Approximately 95 different neisserial isolates tested positive by Western blotting PCR screening methods for the presence gene encoding LP2086....
Pyrazinamide (PZA) is a first-line drug for short-course tuberculosis therapy. Resistance to PZA usually accompanied by loss of pyrazinamidase (PZase) activity in Mycobacterium tuberculosis. PZase converts bactericidal pyrazinoic acid, and the associated with resistance. The gene (pncA) encoding M. has recently been sequenced, mutations pncA were previously found small number PZA-resistant strains. To further understand genetic basis resistance determine frequency strains having mutations,...
A gene (pncA) with mutations associated pyrazinamide resistance in Mycobacterium tuberculosis complex members was characterized 67 pyrazinamide-resistant and 51 pyrazinamide-susceptible isolates recovered from diverse geographic localities anatomic sites typed by IS6110 profiling. All organisms had identical pncA alleles. In striking contrast, 72% of the resistant that altered primary amino acid sequence pyrazinamidase. total 17 previously undescribed were found, including upstream...
The transcription factor GATA1 regulates an extensive program of gene activation and repression during erythroid development. However, the associated mechanisms, including contributions distal versus proximal cis -regulatory modules, co-occupancy with other factors, effects histone modifications, are poorly understood. We studied these problems genome-wide in a Gata1 knockout erythroblast cell line that undergoes GATA1-dependent terminal maturation, identifying 2616 GATA1-responsive genes...
Abstract The identification of clinical and biological markers disease in persons at risk for Huntington (HD) has increased efforts to better quantify characterize the epoch prodrome prior diagnosis. Such are critical design implementation trials HD so that interventions can occur a time most likely increase neuronal survival maximize daily functioning. A prime consideration examination prodromal individuals is their proximity It necessary individual differences key marker variables be...
Most human tumors have abnormal numbers of chromosomes, a condition known as aneuploidy. The mitotic checkpoint is an important mechanism that prevents aneuploidy by restraining the activity anaphase-promoting complex (APC). deubiquitinase USP44 was identified key regulator APC activation; however, physiological importance and its impact on cancer biology are unknown. To clarify role in mitosis, we engineered mouse lacking Usp44. We found regulated prevented chromosome lagging. Mice Usp44...
To evaluate the effects of a 26-week, high-intensity, parent-implemented Early Start Denver Model (P-ESDM) intervention on developmental outcomes, severity autism spectrum disorder (ASD), and parental stress ASD toddlers in China. Subjects P-ESDM group (n = 23) were recruited from 1.5- to 2.5-year-old who screened positive Xuhui Minhang Districts diagnosed with ASD. A community (comparison) age-matched 20) was other areas. attended 1.5-hr parent coaching per week for 26 weeks, those received...
Abstract Tumor-associated macrophages (TAM) play a critical role in cancer development and progression. However, the heterogeneity of TAM presents major challenge to identify clinically relevant markers for protumor TAM. Here, we report that expression adipocyte/macrophage fatty acid–binding protein (A-FABP) promotes breast Although upregulation A-FABP was inversely associated with survival, deficiency significantly reduced mammary tumor growth metastasis. Furthermore, effect mediated by...
Abstract Fatty acid-binding proteins (FABP) are known central regulators of both metabolic and inflammatory pathways, but their role in tumor development remains largely unexplored. Here, we report that host expression epidermal FABP (E-FABP) protects against mammary growth. We find E-FABP is highly expressed macrophages, particularly a specific subset, promoting antitumor activity. In the stroma, E-FABP–expressing tumor-associated macrophages (TAM) produce high levels IFN-β through...
The classical Bordetella subspecies are phylogenetically closely related, yet differ in some of the most interesting and important characteristics pathogens, such as host range, virulence persistence. compelling picture from previous comparisons three sequenced genomes was genome degradation, with substantial loss content (up to 24%) associated adaptation humans.For a more comprehensive lineage evolution, we employed comparative genomic phylogenomic analyses using seven additional diverse,...
Cannabis sativa is a well-known plant species that has great economic and ecological significance. An incomplete genome of cloned C. was obtained by using SOAPdenovo software in 2011. To further explore the utilization this resource, we generated an updated draft sequence for wild-type varieties China PacBio single-molecule sequencing Hi-C technology. Our assembled approximately 808 Mb, with scaffold contig N50 sizes 83.00 Mb 513.57 kb, respectively. Repetitive elements account 74.75%...