A5100430041- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- Circular RNAs in diseases
- Long-Term Effects of COVID-19
- Cancer-related gene regulation
- SARS-CoV-2 and COVID-19 Research
- RNA and protein synthesis mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Kruppel-like factors research
- RNA Interference and Gene Delivery
- COVID-19 diagnosis using AI
- Cancer, Hypoxia, and Metabolism
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Peptidase Inhibition and Analysis
- Extracellular vesicles in disease
- RNA Research and Splicing
- Dysphagia Assessment and Management
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- COVID-19 and healthcare impacts
- Neurological Disease Mechanisms and Treatments
- Cancer Mechanisms and Therapy
Shanghai East Hospital
2020-2025
China Agricultural University
2025
Ministry of Agriculture and Rural Affairs
2025
Zhejiang Provincial People's Hospital
2020-2025
Hangzhou Medical College
2020-2025
Wuchang University of Technology
2025
Fudan University
2024
Shanghai Stomatological Hospital
2024
Second Military Medical University
2007-2024
Changhai Hospital
2022-2024
Abstract Fatty acid-binding proteins (FABP) are known central regulators of both metabolic and inflammatory pathways, but their role in tumor development remains largely unexplored. Here, we report that host expression epidermal FABP (E-FABP) protects against mammary growth. We find E-FABP is highly expressed macrophages, particularly a specific subset, promoting antitumor activity. In the stroma, E-FABP–expressing tumor-associated macrophages (TAM) produce high levels IFN-β through...
Circular RNAs (circRNAs) are key regulators in the development and progression of human cancers, however its role non-small cell lung cancer (NSCLC) tumorigenesis is not well understood. The aim this study to identify expression level circPVT1 NSCLC further investigated functional relevance with both vitro vivo.Quantative real-time PCR was used for measurement specimens lines. Fluorescence situ hybridization analysis (FISH) assay identification sublocation cells. Bioinformatics analysis,...
Aim: This review aims to systematically describe the biogenesis and degradation of circular RNAs (circRNAs), discusses major functions circRNAs, introduces mechanisms by which circRNAs play a role in cancer, comprehensively summarize relationship between anticarcinogen resistance as well underlying specific multiple cancers. Materials & methods: We screened analyzed large quantity scientific papers associated with noncoding RNAs, function, drug chemoresistance, then summarized Figures 1 2...
Exosome-mediated delivery of circular RNAs (circRNAs) is implicated in cancer progression. However, the role exosomal circRNAs chemotherapy resistance tumours remains poorly understood. Here we identified a novel circRNA, circWDR62. It was found that circWDR62 expression upregulated TMZ-resistant glioma cells and cell-derived exosomes compared with their controls by using high-throughput microarray analysis quantitative real-time polymerase chain reaction, high associated poor prognosis...
Abstract Papillary thyroid carcinoma (PTC) stands as the leading cancer type among endocrine malignancies, and there exists a strong correlation between obesity. However, clinical significance molecular mechanism of lipid metabolism in development PTC remain unclear. In this study, it was demonstrated that downregulation METTL16 enhanced promoted malignant progression PTC. expressed at lower levels tissues because DNMT1-mediated hypermethylation its promoter. Loss- gain-of-function studies...
Abstract Background Isocitrate dehydrogenase 1/2 (IDH1/2), BAP1, ARID1A and PBRM1 have been reported as the most frequent mutant genes in intrahepatic cholangiocarcinoma (ICC), their relationships with clinicopathological features prognosis were researched this study. Methods We collected clinical data of 130 ICC patients from January 2012 to December 2017. The IDH1/2 mutation loss expressions detected by DNA sequencing or immunohistochemical methods, histological subtype ICCs was determined...
Although dysregulation of mitochondrial dynamics has been linked to cellular senescence, which contributes advanced age-related disorders, it is unclear how Krüppel-like factor 5 (Klf5), an essential transcriptional cardiovascular remodeling, mediates the link between and vascular smooth muscle cell (VSMC) senescence. Here, we show that Klf5 down-regulation in VSMCs correlated with rupture abdominal aortic aneurysm (AAA), disease. Mice lacking exacerbate senescence progression angiotensin II...
Abstract Background The aquaporins (AQPs) are a family of small membrane transport proteins whose overexpression has been implicated in tumorigenesis. However, the expression AQP5 and AQP8 colorectal cancer clinical significance remain unexplored. This study aimed to detect samples analyze correlations their with clinicopathological features cancer. Methods Forty pairs tissue paraneoplastic normal were obtained at time surgery from patients was detected by immunohistochemical staining...
MicroRNAs (miRNAs), a class of small non-coding RNAs, have been proved as novel and potent regulators adipogenesis. A previous study has found out that miR-144-3p was biomarker type 2 diabetes, but the role in regulating adipogenesis still unclear. In present study, expression increased obese mice during 3T3-L1 differentiation process. Overexpression suppressed cell cycle regulatory factors inhibited pre-adipocytes proliferation. Besides, overexpression accelerated lipid accumulation...
tRNA-derived fragments (tRFs), a novel type of non-coding RNA derived from tRNAs, play an important part in governing gene expressions at post-transcriptional level. To date, the regulatory mechanism tRFs fat deposition and adipogenesis is completely unknown. In this study, high diet was employed to induce obese rat model, transcriptome sequencing conducted identify differentially expressed that response obesity. We found out tRFGluTTC, which promoted preadipocyte proliferation by increasing...
Some studies have reported that activated ribosomes are positively associated with malignant tumors, especially in hepatocellular carcinoma (HCC). The RNA-binding protein PNO1 is a critical ribosome rarely human tumors. This study aimed to explore the molecular mechanisms of HCC. Using 150 formalin-fixed and paraffin-embedded samples 8 fresh samples, we found high expression HCC tumor tissues through Western blotting RT-PCR. Moreover, higher was poor prognosis patients. In vitro vivo...
Metastasis is a serious risk that may occur during the treatment of hepatocellular carcinoma ( HCC ), preventing many patients from being surgical candidates and contributing to poor prognosis. Hypoxia has been proved an important factor metastasis through epithelial–mesenchymal transition EMT ) pathway. Acetyl‐CoA synthase 2 ACSS 2) provides acetyl group for acetylation hypoxia‐inducible HIF )‐2α, this epigenetic modification affects activity ‐2α subsequent process. Here, we showed...
Abstract Many studies have shown that the hyperactivation of ribosome biogenesis plays essential roles in initiation and progression cancers. As a assembly factor, PNO1 an important role biogenesis. However, little is known about expression function human tumors. In our present study, we aimed to explore functional underlying molecular mechanisms lung adenocarcinoma (LUAD). Both bioinformatics databases tumor tissues demonstrated LUAD was higher than adjacent predicted poor survival...
Abstract Background Accurate risk prediction of clinical outcome would usefully inform decisions and intervention targeting in COVID-19. The aim this study was to derive validate models for poor death adult inpatients with Methods Model derivation using data from Wuhan, China used logistic regression (death or severe disease) as outcomes. Predictors were demographic, comorbidity, symptom laboratory test variables. best performing externally validated London, UK. Findings 4.3% the cohort...