A5036741732- Gut microbiota and health
- Diet and metabolism studies
- Alzheimer's disease research and treatments
- Genetics, Aging, and Longevity in Model Organisms
- MicroRNA in disease regulation
- Dietary Effects on Health
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Nutrition and Health in Aging
- Pesticide Residue Analysis and Safety
- Protein Tyrosine Phosphatases
- Fungal Plant Pathogen Control
- RNA regulation and disease
- RNA Research and Splicing
- Genomics, phytochemicals, and oxidative stress
- Telomeres, Telomerase, and Senescence
- Genetics and Neurodevelopmental Disorders
- Circadian rhythm and melatonin
- Clostridium difficile and Clostridium perfringens research
- Immune cells in cancer
- Digestive system and related health
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Research on scale insects
- Single-cell and spatial transcriptomics
Sir Run Run Shaw Hospital
2020-2024
Zhejiang University
2020-2024
Zhejiang Cancer Hospital
2022
Huazhong University of Science and Technology
2017-2020
Beijing University of Agriculture
2019
Colorectal cancer (CRC) is one of the most common malignant tumors and associated with Fusobacterium nucleatum (F. nucleatum, Fn) infection. In this study, we explored role F. in CRC metastasis. Our results showed that abundance was enriched feces patients tended to increase stage IV compared I metastatic CRC. Tumor-derived CCL20 activated by not only increases metastasis, but also participates reprograming tumor microenvironment. promoted macrophage infiltration through activation...
Inflammatory bowel disease (IBD) is defined as an immune dysregulation with poor prognosis. Various therapies based on gut microbe modulation have been proposed. In this study, we aim to explore the therapeutic effect of B. adolescentis IBD, well and microecology mechanism in IBD. The fecal level was decreased IBD patients compared normal people our cohort GMrepo database. To further clarify role induced chronic colitis three cycles dextran sulfate sodium (DSS). We found gavage exhibited...
Metastasis is the leading cause of death for colorectal cancer (CRC) patients, and spreading tumor cells adhesion to endothelial a critical step extravasation further distant metastasis. Previous studies have documented important roles gut microbiota-host interactions in CRC malignancy, Fusobacterium nucleatum (F. nucleatum) was reported increase proliferation invasive activities cells. However, potential functions underlying mechanisms F. between subsequent remain unclear. Here, we...
Abstract Aging‐induced cognitive impairment is associated with a loss of metabolic homeostasis and plasticity. An emerging idea that targeting key metabolites sufficient to impact the function other organisms. Therefore, more metabolism‐targeted therapeutic intervention needed improve impairment. We first conducted untargeted metabolomic analyses 16S rRNA identify aging‐associated adaption intestinal microbiome change. Untargeted plasma revealed L‐arginine was altered during aging process....
Abstract MicroRNAs have been implicated in diverse physiological and pathological processes. We previously reported that aberrant microRNA‐124 (miR‐124)/non‐receptor–type protein phosphatase 1 (PTPN1) signaling plays an important role the synaptic disorders associated with Alzheimer's disease (AD). In this study, we further investigated potential of miR‐124/PTPN1 tau pathology AD. first treated mice intra‐hippocampal stereotactic injections. Then, used quantitative real‐time reverse...
Recently, there has been an increase in the incidence of malignant tumors among older population. Moreover, is association between aging and cancer. During process senescence, human body suffers from a series imbalances, which have shown to further accelerate aging, trigger tumorigenesis, facilitate cancer progression. Therefore, exploring junctions searching for novel methods restore great importance intervene against aging-related cancers. In this review, we identified underlying...
Declined numbers and weakened functions of intestinal stem cells (ISCs) impair the integrity epithelium during aging. However, impact microbiota on ISCs in this process is unclear. Here, using premature aging mice (telomerase RNA component knockout, Terc-/-), natural mice, vitro colonoid models, we explore how heat-inactivated Bifidobacterium adolescentis (B. adolescentis) affects colon senescence. We find that B. could mitigate colonic senescence-related changes by enhancing stimulating...
Abstract The progression of colorectal cancer is closely associated with diet. Fasting-mimicking diet (FMD) a promising type dietary intervention that have beneficial effects in the prevention and treatment various cancers. We investigated therapeutic effect 4-day FMD against mice through immune cell analysis, microbiota composition analysis anti-PD-1 treatment. These cycles effectively suppressed growth, reduced proliferation angiogenesis, increased tumor-infiltration lymphocytes especially...
The relationship between skeletal muscle and cognitive disorders has drawn increasing attention. This study aims to examine the associations of sarcopenia with function dementia risk score. Data on 1978 participants (aged 65 years older) from 2011 wave China Health Retirement Longitudinal Study, four follow-up waves 2018, were used. Cognitive was assessed by dimensions, a lower score indicating function. Dementia using Rotterdam Study Basic Risk Model (BDRM), higher greater risk. Sarcopenia...
Abstract CDK5 activation promotes ischemic neuronal death in stroke, with the recognized mechanism being calpain-dependent p35 cleavage to p25. Here we reported that CDK5-Tyr15 phosphorylation by zinc induced brain injury. and were observed hippocampus of rats had been subjected middle cerebral artery occlusion, both which reversed pretreatment chelator; while calpain ischemia not reversed. Zinc incubation resulted activation, without increasing cultured cells. Site mutation experiment...
In this study, a rapid, sensitive, and selective method was established for the detection of oxathiapiprolin metabolite IN-E8S72, as well its glucose conjugate IN-SXS67 in cucumber using modified QuEChERS procedure combined with HPLC–MS/MS. The LOQs all compounds were 0.02 mg kg–1, average recoveries 77.4–111.3% RSDs 1.0–8.5%. Under optimized conditions, successfully used to determine field samples dissipation terminal residue studies. study results showed that dissipated rapidly half-lives...
NMN prolonged the life span and delayed senescence in premature ageing mice.
Tauopathies are a class of neurodegenerative diseases that characterized by pathological aggregation tau protein, which is accompanied synaptic disorders. However, the role in endocytosis, fundamental process transmission, remains elusive. Here, we report forced expression human (hTau) mouse cortical neurons impairs endocytosis decreasing level GTPase dynamin 1 via disruption miR-132-MeCP2 pathway; this can also be detected brains Alzheimer's patients and hTau mice. Our results provide...
Abstract BACKGROUND Several diseases and insects may cause damage to the normal growth of cucumber. Azoxystrobin meptyldinocap, because their novel mode action, are effective against pathogens that have developed reduced sensitivity other fungicides. is persistent in various crops environments. However, there a lack research on dissipation these two pesticides, especially meptyldinocap. RESULTS Analytes could be quantified with decent recoveries 90–101%, relative standard deviations (RSDs)...
FMD prolongs life, improves cognition and slows the ageing of intestines. Microbiota gut immunity may play a role.
Pathogenesis of AD is unclear, and the majority patients are non-familial AD. Moreover, current treatments targeting Aβ, tau, do not achieve satisfactory effects. Therefore, it necessary to investigate pathogenesis provide new strategies for from a field. Many studies indicate that aberrant expression functional alteration miRNAs may be involved in AD, but underling mechanisms unclear. 12-month Tg2576 model transgenic mice were used this study. array quantitative real time PCR (qRT-PCR)...
Abstract Microbiota-host interaction was involved in aging, while the specific bacterium undetermined. To identify candidate with we performed fecal microbiota sequencing. Less richness of gut microbial community, and a reduction B.adolescentis abundance observed elderly individuals. B. adolescentis supplement improved osteoporosis neurodegeneration telomerase RNA component deletion (Terc −/− ) aged mice. induced prolongevity healthspan improvement Drosophila melanogaster C. elegans ....
Background: The relationship between skeletal muscle and cognitive disorders has drawn increasing attention. This study aimed to examine the associations of sarcopenia with function dementia risk.Methods: Data on 8387 participants (aged 45 years older) from 2011 wave China Health Retirement Longitudinal Study, 4 follow-up waves 2018, were used. Cognitive was assessed by dimensions: orientation, attention & calculation, episodic memory, visuospatial ability, lower scores indicating function....