A5034010284- Alzheimer's disease research and treatments
- Insect Resistance and Genetics
- RNA modifications and cancer
- MicroRNA in disease regulation
- Insect-Plant Interactions and Control
- Allelopathy and phytotoxic interactions
- Congenital heart defects research
- Cancer-related gene regulation
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Multiple Sclerosis Research Studies
- Protein Tyrosine Phosphatases
- Nerve injury and regeneration
- Cytokine Signaling Pathways and Interactions
- Seed Germination and Physiology
- Plant and Fungal Interactions Research
- Mosquito-borne diseases and control
- Molecular Biology Techniques and Applications
- Oral and gingival health research
- Signaling Pathways in Disease
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Insect symbiosis and bacterial influences
- Ginseng Biological Effects and Applications
- Cholinesterase and Neurodegenerative Diseases
- Developmental Biology and Gene Regulation
Shandong Provincial QianFoShan Hospital
2024
Shandong First Medical University
2024
Huazhong University of Science and Technology
2012-2023
Second Xiangya Hospital of Central South University
2022
Central South University
2022
Nanjing Medical University
2021
Harbin Medical University
2021
Nanjing University of Chinese Medicine
2021
Bengbu Medical College
2019-2020
Second Military Medical University
2019
Abstract Aberrant regulation of microRNAs (miRNAs) has been implicated in the pathogenesis Alzheimer’s disease (AD), but most abnormally expressed miRNAs found AD are not regulated by synaptic activity. Here we report that dysfunction miR-135a-5p/Rock2/Add1 results memory/synaptic disorder a mouse model AD. miR-135a-5p levels significantly reduced excitatory hippocampal neurons mice. This decrease is tau dependent and mediated Foxd3. Inhibition leads to memory impairments. Furthermore,...
The neuron-glia cross-talk is critical to brain homeostasis and particularly affected by neurodegenerative diseases. How neurons manipulate the neuron-astrocyte interaction under pathological conditions, such as hyperphosphorylated tau, a hallmark in Alzheimer’s disease (AD), remains elusive. In this study, we identified excessively elevated neuronal expression of adenosine receptor 1 (Adora1 or A1R) 3×Tg mice, MAPT P301L (rTg4510) patients with AD, patient-derived neurons. up-regulation A1R...
The population structure of the chestnut blight fungus, Cryphonectria parasitica was analyzed using restriction fragment length polymorphisms (RFLPs). A total 791 isolates were sampled from four regions, China, Japan, North America and Europe, assayed for alleles at eight RFLP loci. Alleles all loci segregated in simple Mendelian ratios, most unlinked. Gene diversity decomposed hierarchically: 56% gene attributable to within subpopulations, compared 7% among subpopulations 37% regions....
Abstract MicroRNAs have been implicated in diverse physiological and pathological processes. We previously reported that aberrant microRNA‐124 (miR‐124)/non‐receptor–type protein phosphatase 1 (PTPN1) signaling plays an important role the synaptic disorders associated with Alzheimer's disease (AD). In this study, we further investigated potential of miR‐124/PTPN1 tau pathology AD. first treated mice intra‐hippocampal stereotactic injections. Then, used quantitative real‐time reverse...
Cholinergic degeneration is one of the key pathological hallmarks Alzheimer’s disease (AD), a condition that characterized by synaptic disorders and memory impairments. Nerve growth factor (NGF) secreted in brain regions receive projections from basal forebrain cholinergic neurons. The trophic effects NGF rely on appropriate maturation its precursor, proNGF. ratio proNGF/NGF known to be increased patients with AD; however, mechanisms underlie this observation have yet elucidated. Here, we...
Background HES/HEY genes encode a family of basic helix-loop-helix (bHLH) transcription factors with both bHLH and Orange domain. proteins are direct targets the Notch signaling pathway play an essential role in developmental decisions, such as developments nervous system, somitogenesis, blood vessel heart. Despite their important functions, origin evolution this gene has yet to be elucidated. Methods Findings In study, we identified representative species performed evolutionary analysis...
Abstract Background Diamond–Blackfan anemia is a rare congenital red blood cell dysplasia that develops soon after birth. RPL11 mutations account for approximately 4.8% of human DBA cases with defective hematopoietic phenotypes. However, the mechanisms by which regulates hematopoiesis in remain elusive. In this study, we analyzed transcriptome using deep sequencing data from an Rpl11-deficient zebrafish model to identify Rpl11-mediated failure and investigate underlying mechanisms. Results...
Diamond-Blackfan anemia (DBA) is a rare inherited bone marrow failure syndrome that characterized by pure red-cell aplasia and associated physical deformities. It has been proven defects of ribosomal proteins can lead to this disease RPS19 the most frequently mutated gene in DBA patients. Previous studies suggest p53-dependent genes pathways play important roles RPS19-deficient embryos. However, whether there are other vital factors linked not fully clarified. In study, we compared whole...
本研究探讨了连续3年5种不同化感潜力水稻田间抑草效应、产量及其之间相互关系。结果表明, 不同种植时间, 不同化感潜力水稻田间种植过程中伴生杂草总生物量以非化感水稻"Lemont"最大, 化感水稻"PI-1"最小。化感潜力分析结果表明, 不同化感潜力水稻以化感水稻"PI-1"化感抑草潜力最强, 非化感水稻"Lemont"最弱。水稻产量分析结果表明, 不除草条件下, 不同种植时间均以化感水稻"PI-1"产量最高, 非化感水稻"Lemont"产量最低。除草条件下, 依然以化感水稻"PI-1"产量最高, 化感水稻"IAC47"产量最小。杂草生物量、水稻化感潜力与水稻产量的相关性分析结果表明, 不同化感潜力水稻产量的大小与田间杂草生物量存在极显著负相关, 与化感潜力大小存在极显著正相关。
Noma is a progressive infectious disease manifested by necrotic ulcer of the mouth and face. It usually occurs in poor, malnourished children, with about 30,000-140,000 cases each year low survival rate. The exact cause noma remains unclear, but bacterial infection has been postulated to be major this disease. Antibiotics improved nutrition could help inhibit progression noma, most patients still require oral surgery because infection-induced tissue damage. In study, we report an unusual...
// Yang Zhou 1 , Mingxun Li 1, 2 Xinde Hu 3, 4 Hanfang Cai Liushuai Hua 5 Jing Wang Yongzhen Huang Xianyong Lan Chuzhao Lei George E. Liu 6 Congjun Martin Plath and Hong Chen College of Animal Science Technology, Northwest A&F University, Shaanxi Key Laboratory Agricultural Molecular Biology, Yangling, 712100, China Yangzhou Yangzhou, Jiangsu 225009, 3 Institute Neuroscience, Chinese Academy Sciences, Shanghai 200031, Veterinary Medicine, Husbandry Science, Henan Breeding Nutritional...
Abstract The cuticle protein (CP) encoded by CPR63 plays a role in deltamethrin resistance Culex pipiens pallens . Herein, we investigated the distribution of transcripts this organism, and revealed high expression levels legs wings. Furthermore, deltamethrin-resistant (DR) strains were 1.79-fold higher than deltamethrin-susceptible (DS) strains. Cuticle analysis small interfering RNA (siRNA) groups scanning electron microscopy (SEM) significantly thinner procuticle tarsi siCPR63 group siNC...
Abstract Background MicroRNAs have been implicated in diverse physiological and pathological processes. Method Cell Culture Treatment, RNA Isolation Quantitative Real‐Time PCR (qRT‐PCR), Preparation of Soluble Insoluble Fraction. Result We demonstrated that disturbance the miR‐124/PTPN1 signal induced animbalance phosphatase/kinase system by enhancing tyrosine phosphorylation GSK‐3β PP2A, which then caused activation inactivation PP2A ultimately led to AD‐like tauopathy. Conclusion first...
Severe refractory anemia during pregnancy can cause serious maternal and fetal complications. If the cannot be identified in time accurately, blind symptomatic support treatment may economic burden. Thalassemia minor is commonly considered uneventful, condition of rarely progresses pregnancy. Autoimmune hemolytic (AIHA) rare with no exact incidence available.We report case a 30-year-old β-thalassemia multiparous patient experiencing severe throughout We monitored closely, carried out full...
Abstract Pathological cardiac hypertrophy is a process characterized by significant disturbance of protein turnover. Cullin-associated and Neddylation-dissociated 1 (CAND1) acts as coordinator to modulate substrate degradation promoting the formation specific cullin-based ubiquitin ligase 3 complex in response accumulation proteins, which thereby maintains normal homeostasis. However, whether CAND1 titrates hypertrophic related proteins manipulates remains unknown. In this study, we found...