A5056470465- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA modifications and cancer
- Fuel Cells and Related Materials
- Cardiac Fibrosis and Remodeling
- Plasma Diagnostics and Applications
- Mitochondrial Function and Pathology
- RNA regulation and disease
- Signaling Pathways in Disease
- Circular RNAs in diseases
- Electrohydrodynamics and Fluid Dynamics
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Peptidase Inhibition and Analysis
- Fault Detection and Control Systems
- Particle accelerators and beam dynamics
- Heat shock proteins research
- Sentiment Analysis and Opinion Mining
- Retinoids in leukemia and cellular processes
- Advanced Text Analysis Techniques
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cardiac Structural Anomalies and Repair
- Topic Modeling
- HVDC Systems and Fault Protection
- Cryptographic Implementations and Security
Harbin Medical University
2013-2025
Second Affiliated Hospital of Harbin Medical University
2019-2025
Ministry of Education of the People's Republic of China
2025
University of Strathclyde
2024
Institute of Physics
2020-2024
Hefei University of Technology
2022-2023
Linyi People's Hospital
2022
Yanshan University
2021
China Academy of Space Technology
2021
Justus-Liebig-Universität Gießen
2020
N6-methyladenosine (m6A) RNA modification, a dynamic and reversible process, is essential for tissue development pathogenesis. However, the potential involvement of m6A in regulation cardiomyocyte (CM) proliferation cardiac regeneration remains unclear. In this study, we aimed to investigate role modification heart during postnatal adult injury. Methods results: identified downregulation demethylase ALKBH5, an "eraser" that responsible increased methylation, after birth. Notably, ALKBH5...
Heart failure (HF) is a major cause of morbidity and mortality in patients with various cardiovascular diseases. Restoration cardiac function critical improving the clinical outcomes HF. Long noncoding RNAs are widely involved development multiple diseases, whereas their role regulating remains unclear. In this study, we found that expression long RNA-DACH1 (dachshund homolog 1) was upregulated failing hearts mice human. We tested hypothesis intronic RNA DACH1 (LncDACH1) can participate...
ASPP1 (apoptosis stimulating of p53 protein 1) is critical in regulating cell apoptosis as a cofactor to promote its transcriptional activity the nucleus. However, whether cytoplasmic affects nuclear trafficking and role cardiac diseases remains unknown. This study aims explore mechanism by which modulates subsequent contribution ischemia/reperfusion (I/R) injury.The immunofluorescent staining showed that under normal condition colocalized cytoplasm neonatal mouse ventricular cardiomyocytes,...
Nonalcoholic fatty liver disease (NAFLD) is the most common disorder with high morbidity and mortality. The current study aims to explore role of Cullin-associated neddylation-dissociated protein 1 (CAND1) in development NAFLD underlying mechanisms. CAND1 reduced male patients fat diet (HFD)-fed mice. alleviates palmitate (PA) induced lipid accumulation vitro. Hepatocyte-specific knockout exacerbates HFD-induced injury HFD-fed mice, while hepatocyte-specific knockin ameliorates these...
Background/Aims: Doxorubicin is a widely used chemotherapeutic agent, but its clinical use restricted because of high risk cardiotoxicity. Bone marrow-derived mesenchymal stem cells (BMSCs) may repair ischaemically damaged myocardium through transdifferentiation and paracrine action. The aim this study to investigate if doxorubicin causes the apoptosis BMSCs in turn impairs healing ability. Methods: were exposed doxorubicin, cell was determined by western blot stainings. Results: reduced...
Abstract Bone marrow-derived mesenchymal stem cells (BMSCs) have emerged as a promising therapeutic strategy for cardiovascular disease. However, there is no evidence so far that BMSCs can heal pathological myocardial hypertrophy. In this study, were indirectly cocultured with neonatal rat ventricular cardiomyocytes (NRVCs) in vitro or intramyocardially transplanted into hypertrophic hearts vivo. The results showed isoproterenol (ISO)-induced typical characteristics of prevented by the...
Dystrophin is a critical interacting protein of Nav1.5 that determines its membrane anchoring in cardiomyocytes. Long noncoding RNAs (lncRNAs) are involved the regulation cardiac ion channels, while their influence on sodium channels remains unexplored. Our preliminary data showed lncRNA- Dachshund homolog 1 ( lncDach1 ) can bind to dystrophin, which drove us investigate if regulate by interfering with dystrophin. Western blot and immunofluorescent staining cardiomyocyte-specific transgenic...
This study investigated Hippo signaling pathway-related biomarkers in acute myocardial infarction (AMI). First, differentially expressed genes (DEGs) between AMI patients and controls were identified. Consensus clustering then classified subtypes, followed by subtype-specific DEG screening. Candidate derived from intersecting initial DEGs with subtype-associated DEGs. Three machine-learning algorithms prioritized five (NAMPT, CXCL1, CREM, GIMAP6, GIMAP7), validated through multi-dataset...
Bone marrow mesenchymal stem cells (BMSCs) are capable of homing to and repair damaged myocardial tissues. Apoptosis BMSCs in response various pathological stimuli leads the attenuation healing ability BMSCs. Plenty evidence has shown that elevated homocysteine level is a novel independent risk factor cardiovascular diseases. The present study was aimed investigate whether may induce apoptosis its underlying mechanisms. Here we uncovered significantly inhibited cellular viability...
Background/Aims: Low ambient temperature is an important risk factor for cardiovascular diseases, and has been shown to lead cardiac hypertrophy. In this study, we aim investigate if Resveratrol may inhibit cold exposure-induced hypertrophy in mice, so clarify its molecular mechanism. Methods: Adult male mice were randomly assigned Control group (kept at room temperature), Cold low air range from 3°C 5°C) treatment (100mg/kg/day) eight weeks. HE staining, Masson staining Transmission...
Abstract Myocardial ischemia/reperfusion (MI/R) injury is a pathological process that seriously affects the health of patients with coronary artery disease. Long non-coding RNAs (lncRNAs) represents new class regulators diverse biological processes and disease conditions, study aims to discover pivotal lncRNA in MI/R injury. The microarray screening identifies down-regulated heart-enriched lncRNA-CIRPIL (Cardiac ischemia reperfusion associated p53 interacting lncRNA, lncCIRPIL) from hearts...
Arsenic trioxide (ATO) has been well recognized as an anti-tumor agent for various human cancers.Recently, the blue light emitting diodes (LEDs)-based therapy also demonstrated to be potential therapeutic strategies several cancers.However, combination effects of ATO and LED on tumor suppression are still unclear.In this study, we determined whether irradiation at 470 nm in wavelength exhibited superior activity osteosarcoma (OS).We observed that treatments much more significantly decreased...
NPC (nasopharyngeal carcinoma) is a common malignancy in southern China without defined aetiology. Recent studies have shown that TGFBR3 (transforming growth factor type III receptor, also known as betaglycan), exhibits anticancer activities. This study was to investigate the effects of on and mechanisms for its actions. Effects overexpression cell viability apoptosis were measured by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide], AO/EB (acridine orange/ethidium...
Cardiac ventricular arrhythmia triggered by acute myocardial infarction (AMI) is a major cause of sudden cardiac death. We have reported previously that an increased serum level circular RNA CDR1as potential biomarker AMI. However, the possible role in post-infarct remains unclear. This study MI mice investigated effects and underlying mechanism arrhythmias associated with MI. showed knockdown abbreviated duration abnormally prolonged QRS complex QTc intervals decreased susceptibility to...