A5017413913- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Immune cells in cancer
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Orthopedic Surgery and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Shoulder Injury and Treatment
- Bone fractures and treatments
- Shoulder and Clavicle Injuries
- Hydrogen's biological and therapeutic effects
- Hip disorders and treatments
- Knee injuries and reconstruction techniques
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Orthopaedic implants and arthroplasty
- Cardiac Ischemia and Reperfusion
- Inflammasome and immune disorders
- Hip and Femur Fractures
- Hippo pathway signaling and YAP/TAZ
- Liver Disease and Transplantation
- Musculoskeletal Disorders and Rehabilitation
- PARP inhibition in cancer therapy
- Seaweed-derived Bioactive Compounds
Jiangnan University
2025
Tianjin Chest Hospital
2022-2024
Ministry of Education of the People's Republic of China
2024
Shandong University
2024
University of Rome Tor Vergata
2023-2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Hainan University
2020-2023
Soochow University
2020-2023
First Affiliated Hospital of Soochow University
2020-2023
Central South University
2011-2023
Abstract Despite the widespread use of blockade immune checkpoints, for a significant number cancer patients, these therapies have proven ineffective, presumably due to immunosuppressive nature tumor microenvironment (TME). Critical drivers escape in TME include tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), which not only mediate suppression, but also facilitate metastatic dissemination impart resistance immunotherapies. Thus, strategies that convert them...
Bone marrow-derived mesenchymal stem cells (BMSCs) have been suggested to possess the capacity differentiate into different cell lineages. Maintaining a balanced differentiation program is crucial bone microenvironment and development. MicroRNAs (miRNAs) played critical role in regulating of BMSCs particular lineage. However, miR-149-3p adipogenic osteogenic has not extensively discovered. In this study, we aimed detect expression levels during investigate whether participated lineage choice...
Abstract Bone marrow mesenchymal stem cells ( BMSC s) are an expandable population of which can differentiate into osteoblasts, chondrocytes and adipocytes. Dysfunction s in response to pathological stimuli contributes bone diseases. Melatonin, a hormone secreted from pineal gland, has been proved be important mediator formation mineralization. The aim this study was investigate whether melatonin protected against iron overload‐induced dysfunction its underlying mechanisms. Here, we found...
Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to differentiate into osteoblasts or adipocytes, and shift between osteogenic adipogenic differentiation determines bone mass. The aim of this study was identify whether lncRNAs are involved in commitment BMSCs during osteoporosis. Here, we found ORLNC1, a functionally undefined lncRNA that is highly conserved, which exhibited markedly higher expression levels BMSCs, tissue, serum OVX-induced osteoporotic mice than...
Distinct metabolic programs, either energy-consuming anabolism or energy-generating catabolism, were required for different biological functions. Macrophages can adopt immune phenotypes in response to various cues and exhibit anti- pro-inflammatory properties relying on catabolic pathways associated with oxidative phosphorylation (OXPHOS) glycolysis. Spermidine, a natural polyamine, has been reported regulate inflammation through inducing anti-inflammatory (M2) macrophages. However, the...
Mesenchymal stem/stromal cells (MSCs) acquire immunosuppressive capacity only in an inflammatory microenvironment. This can be recapitulated vitro by treating MSCs with cytokines TNFα and IFNγ, which induce indoleamine 2,3-dioxygenase (IDO) TNF-stimulated gene-6 (TSG-6). However, the signaling pathways downstream of remain to elucidated.Inflammatory bowel disease (IBD) mouse model was established subjecting mice dextran sulfate sodium (DSS) drinking water for 7 days. Human UC-MSCs were...
Background/Aims: Bone marrow-derived mesenchymal stem cells (BMSCs) have the ability to differentiate into multilineage such as osteoblasts, chondrocytes, and cardiomyocytes. Dysfunction of BMSCs in response pathological stimuli participates development diseases osteoporosis. Astragalus polysaccharide (APS) is a major active ingredient membranaceus, commonly used anti-aging herb traditional Chinese medicine. The aim this study was investigate whether APS protects against iron...
In recent years, microRNA-495 (miR-495) has been reported to be a tumor-suppressor miR that is down-modulated in cancers. However, its potential mechanism remains unknown. Therefore, this study aimed demonstrate the role of miR-495 cardiac microvascular endothelial cell (CMEC) injury and inflammatory reaction by mediating pyrin domain-containing 3 (NLRP3) inflammasome signaling pathway.Overall, 40 mice were assigned into myocardial ischemia/reperfusion (MIR) sham groups. After model...
Abstract Psoriasis is currently an incurable skin disorder mainly driven by a chronic inflammatory response. We found that subcutaneous application of umbilical cord- derived mesenchymal stem/stromal cells (MSCs) primed IFN-γ and TNF-α, referred to as MSCs-IT, exhibited remarkable therapeutic efficacy on imiquimod (IMQ)-induced psoriasis-like inflammation in mice. Neutrophil infiltration, hallmark psoriasis, was significantly reduced after treatment with MSCs-IT. further demonstrated the...
Osteoporosis is closely associated with the dysfunction of bone metabolism, which caused by imbalance between new formation and resorption. Osteogenic differentiation plays a vital role in maintaining balance microenvironment. The present study investigated whether melatonin participated osteogenic commitment marrow mesenchymal stem cells (BMSCs) further explored its underlying mechanisms. Our data showed that exhibited capacity regulating BMSCs, was blocked membrane receptor inhibitor...
Background/Aims: Blue light emitting diodes (LEDs) have been proven to affect the growth of several types cells. The effects blue LEDs not tested on bone marrow-derived mesenchymal stem cells (BMSCs), which are important for cell-based therapy in various medical fields. Therefore, aim this study was determine LED proliferation, apoptosis and osteogenic differentiation BMSCs. Methods: BMSCs were irradiated with a at 470 nm 1 min, 5 10 30 min 60 or irradiated. Cell proliferation measured by...
Abstract Background Muscle stem cells (MuSCs) are absolutely required for the formation, repair, and regeneration of skeletal muscle tissue. Increasing evidence demonstrated that tissue cells, especially mesenchymal (MSCs), can exert therapeutic effects on various degenerative inflammatory disorders based their immunoregulatory properties. Human (hMSCs) treated with interferon-γ (IFN-γ) tumor necrosis factor-α (TNF-α) were reported to possess anti-inflammatory functions by producing...
The structures and immunomodulatory activities of purified neutral polysaccharides from fresh (FLP) hot air-dried (DLP) longan were comparatively investigated. FLP was composed mannose glucose at a molar ratio 0.59:1 with average molecular weight 1.31 × 107 g/mol, DLP rhamnose, mannose, galactose 0.2:0.21:1:0.2 1.06 g/mol. Methylation NMR data showed that primarily →6)-α-D-Glcp-(1→, →3)-β-D-Glcp-(1→, →3)-β-D-Galp-(1→ →3)-α-L-Rhap-(1→. significantly enhanced lymphocyte proliferation,...
This study mainly explored the regulatory role and mechanism of MCCC2 in GBM. verified expression clinical samples GBM cell lines. CCK-8 cloning experiments, flow cytometry, scratch experiments Transwell chamber were used to detect effects on proliferation, apoptosis, migration invasion cells. A reduction could significantly lower protein levels ERK, decrease p-ERK levels, inhibit ERK phosphorylation. Ulixertinib, an inhibitor, was shown hinder migration, cells counteract impact...
// Fan Yang 2, * , Yuan Li Gege Yan 2 Tianyi Liu Chao Feng Rui Gong Ye 3 Fengzhi Ding Lai Zhang Elina Idiiatullina 4 Valentin Pavlov Zhenbo Han Wenya Ma Qi Huang Ying Yu Zhengyi Bao Xiuxiu Wang Bingjie Hua Zhimin Du Benzhi Cai Lei 1 Department of Orthopedics, The First Affiliated Hospital Harbin Medical University, 150001, China Pharmacology, College Pharmacy, 150081, Clinical Second 150086, Central Laboratory Scientific Research, Bashkir State Ufa 450008, Russia These authors contributed...
As a polyphenol, ellagic acid (EA) has shown potential antidepressant activity. In this study, the effects and serum metabolomic analysis of EA against depression were investigated using chronic unpredictable mild stress-induced (CUMS) model. (20 or 100 mg/kg body weight) significantly ameliorated CUMS-induced depression-like behaviors, including reduced weight, decreased sucrose preference, increased immobility time in both tail suspension test forced swimming test. Furthermore, attenuated...
Closed reduction and percutaneous pin fixation is the recommended treatment of displaced supracondylar humerus fractures. The optimal configurations in fractures with coronal lateral obliquity remain controversial. aim this study was to compare stability various oblique provide an acceptable placement.Nine third-generation synthetic composite humeri were osteotomized simulate a humeral fracture obliquity. Each reduced fixed using 2 or three 1.6-mm (0.062 in) Kirschner wires (K-wire) 3...
MicroRNAs (miRNAs) have been proven to regulate gene expression at the protein translation level. miRNA abnormal has associated with development of lung cancer. In present study, we aimed investigate mechanism miR-196 in non-small cell cancer (NSCLC). The miR-196b and GATA-6 (GATA6) levels were examined NSCLC by RT-qPCR western blot analysis. Transwell assay was used assess migration invasion. Moreover, specific target verified luciferase reporter assay. higher both tissues cells than normal...
Muscle stem cells (MuSCs) have been demonstrated to exert impressive therapeutic efficacy in disease settings through orchestrating inflammatory microenvironments. Nevertheless, the mechanisms underlying immunoregulatory property of MuSCs remain largely uncharacterized. Here, we showed that interleukin-4-induced-1 (IL4I1), an essential enzyme catalyzes indole metabolism humans, was highly expressed human exposed IFN-γ and TNF-α. Functionally, were found inhibit infiltration neutrophils into...