A5101608586- Neuroinflammation and Neurodegeneration Mechanisms
- Connexins and lens biology
- Neurological Disease Mechanisms and Treatments
- Peripheral Neuropathies and Disorders
- Neuroscience and Neuropharmacology Research
- Acute Ischemic Stroke Management
- Hereditary Neurological Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Heme Oxygenase-1 and Carbon Monoxide
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Ischemia and Reperfusion
- Prion Diseases and Protein Misfolding
- Heat shock proteins research
- Nerve injury and regeneration
- Alzheimer's disease research and treatments
- Anesthesia and Neurotoxicity Research
- Autophagy in Disease and Therapy
- Neurological Disorders and Treatments
- Traditional Chinese Medicine Analysis
- Neurological diseases and metabolism
- Barrier Structure and Function Studies
- Cerebrovascular and Carotid Artery Diseases
- Long-Term Effects of COVID-19
- Macrophage Migration Inhibitory Factor
- Inflammasome and immune disorders
First Hospital of Jilin University
2015-2025
Jilin University
2015-2025
First Bethune Hospital of Jilin University
2011-2023
Xiangya Hospital Central South University
2011
Sun Yat-sen University
2011
Norwegian University of Science and Technology
2011
Chinese PLA General Hospital
2011
Air Force Medical University
2011
Central South University
2011
Huashan Hospital
2011
Objectives.— In the absence of reliable data on prevalence and burden primary headache disorders in mainland China, a population‐based survey was initiated by Lifting The Burden : Global Campaign against Headache. Methods.— Throughout all regions 5041 non‐related adult respondents aged 18‐65 years were randomly sampled from general population according to expanded programme immunization method established World Health Organization. They visited door‐to‐door calling surveyed using structured...
Glia-mediated neuroinflammation is related to brain injury exacerbation after cerebral ischemia/reperfusion (I/R) injury. Astrocytic hemichannels or gap junctions, which were mainly formed by connexin-43, have been implicated in I/R damage. However, the exact roles of astrocytic and junction neuroinflammatory responses induced remain unknown. Primary cultured astrocytes subjected OGD/R injury, an vitro model Salvianolic acid B (SalB) carbenoxolone (CBX) applied for those astrocytes. Besides,...
The electrochemiluminescence (ECL) immunoassay with its visual and high-throughput detection has received considerable attention in the past decade. However, development of a facile cost-effective ECL device is still great challenge. Herein, single-electrode electrochemical system (SEES) for was developed. SEES designed by attaching plastic sticker multiple holes onto single carbon ink screen-printed electrode based on resistance-induced potential difference. Due to excellent properties...
Alzheimer's disease (AD) is one of the most common neurodegenerative and accumulating evidences suggest an active role inflammation in pathogenesis AD. Inflammation resolution process that terminates facilitates restoration inflamed tissue to homeostasis. Resolution has been shown be conducted by a group specialized pro-resolving lipid mediators (SPMs) including lipoxins, resolvins, protectins, maresins (MaRs). Recent studies have demonstrated failure can lead chronic and, hence, contribute...
Vinpocetine (Vinp) is known for its neuroprotective properties. However, the protective mechanism of Vinp against cerebral ischemia/reperfusion (I/R) injury should be further explored. This study was designed to investigate effects oxygen-glucose deprivation/reoxygenation (OGD/R) in vitro and I/R vivo explore whether this would involve enhancement astrocytic connexin 43 (Cx43) expression via phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway. In vitro, we detected viability...
To investigate the existence of an association between compensatory remodeling in symptomatic middle cerebral artery atherosclerotic stenosis with high-resolution magnetic resonance imaging (HR MRI) and transcranial color Doppler monitoring microembolic signals (MESs).A total 36 consecutive patients underwent MES by 3-T HR MRI. Proton density-weighted cross-sectional images submillimeter voxel size were obtained. The patterns plaque morphology sites maximal luminal narrowing analyzed terms...
This study investigated the neuroprotective effect of salvianolic acids (SA) against ischemia/reperfusion (I/R) injury, and explored whether neuroprotection was dependent on mitochondrial connexin43 (mtCx43) via phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway. In vitro, we measured astrocyte apoptosis, membrane potential, also evaluated morphology mitochondria with transmission electron microscopy. vivo, determined cerebral infarction volume superoxide dismutase (SOD)...
Stroke is the second leading cause of death worldwide and most common adult-acquired disability in many nations. Thus, attenuating damage after ischemic injury improving patient prognosis are great importance. We have indicated that preconditioning (IP) can effectively reduce ischemia reperfusion inhibition gap junctions may further this damage. Although we confirmed function closely associated with glutamate, did not investigate mechanism. In present study, aimed to clarify whether blockade...
Atherosclerosis is a common cardiovascular disease caused by the abnormal expression of multiple factors and genes influenced both environmental genetic factors. The primary manifestation atherosclerosis plaque formation, which occurs when inflammatory cells consume excess lipids, affecting their retention modification within arterial intima. This triggers endothelial cell (EC) activation, immune infiltration, vascular smooth muscle (VSMC) proliferation migration, foam lipid streaks, fibrous...
Epilepsy is a common neurological disorder characterized by naturally-occurring spontaneous recurrent seizures and comorbidities. Kindling has long been used to model epileptogenic mechanisms assess antiepileptic drugs. In particular, extended kindling can induce without gross brain lesions, as seen clinically. To date, the development of following kindling, effect drugs on these are not well understood. present study we aim develop mouse hippocampal for first time. Once established, plan...
As the first peripheral immune cells to enter brain after ischemic stroke, neutrophils are important participants in stroke-related neuroinflammation. Neutrophils quickly mobilized from periphery response a stroke episode and cross blood-brain barrier reach parenchyma. This process involves mobilization activation of organs (including bone marrow spleen), their chemotaxis blood, infiltration into parenchyma disruption barrier, inflammatory effects on tissue, interactions with other cell...
Neurological deterioration after intracerebral hemorrhage (ICH) is thought to be closely related increased intracranial pressure (ICP), decreased cerebral blood flow (CBF), and brain metabolism. Transcranial Doppler (TCD) increasingly used as an indirect measure of ICP, quantitative EEG (QEEG) can reflect the coupling CBF We aimed combine TCD QEEG comprehensively assess function ICH provide prognostic diagnosis.We prospectively enrolled patients with severe acute supratentorial (SAS)-ICH...
Connexin-43 (Cx43) is the most abundant gap junction protein in nervous system. It enables cell communication and has important physiological roles including ion transport substrate exchange, all of which have been implicated cerebral ischemia injury. Our previous vitro vivo studies demonstrated that Cx43 internalized degraded during stress. However, significance ischemia-induced degradation remains unclear. Herein, we injury mediated by selective autophagy; additionally, identified two...