A5101476654- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Neuroinflammation and Neurodegeneration Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Alzheimer's disease research and treatments
- Fatty Acid Research and Health
- Metabolism and Genetic Disorders
- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Sphingolipid Metabolism and Signaling
- Diet and metabolism studies
- Pharmacological Receptor Mechanisms and Effects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Spine and Intervertebral Disc Pathology
- Neonatal and fetal brain pathology
- Calcium signaling and nucleotide metabolism
- Cerebrovascular and Carotid Artery Diseases
- Genomics and Rare Diseases
- Galectins and Cancer Biology
- Blood Pressure and Hypertension Studies
- Ovarian cancer diagnosis and treatment
- Advanced Glycation End Products research
- Cognitive Abilities and Testing
- Cancer Treatment and Pharmacology
- Autophagy in Disease and Therapy
Qilu Hospital of Shandong University
2019-2025
Affiliated Hospital of Jining Medical University
2024
Third Xiangya Hospital
2024
Central South University
2024
Shuguang Hospital
2022
Shanghai University of Traditional Chinese Medicine
2022
Heilongjiang Provincial Hospital
2018-2021
Harbin Institute of Technology
2020
First Hospital of Jilin University
2018-2019
Jilin University
2018-2019
Alzheimer's disease (AD) is a chronic progressive neurodegenerative disorder. However, its pathogenetic mechanism still poorly understood. An increasing number of studies have evidenced the important role long noncoding RNAs (lncRNAs) in AD. The aim current study was to investigate effect and molecular lncRNA X-inactive specific transcript (XIST) Bilateral common carotid artery occlusion (2VO) used induce an AD model mice. Hydrogen peroxide (H2 O2 ) N2a cells. XIST, miR-124, BACE1 messenger...
Alzheimer's disease (AD) is one of the most common neurodegenerative and accumulating evidences suggest an active role inflammation in pathogenesis AD. Inflammation resolution process that terminates facilitates restoration inflamed tissue to homeostasis. Resolution has been shown be conducted by a group specialized pro-resolving lipid mediators (SPMs) including lipoxins, resolvins, protectins, maresins (MaRs). Recent studies have demonstrated failure can lead chronic and, hence, contribute...
Alzheimer's disease (AD) is the most prevalent neurodegenerative in elderly individuals and characterized by impaired cognition accumulation of β-amyloid (Aβ). Activating autophagy to clear Aβ a plausible approach for AD treatment. The levels signaling factors APP695/PS1-dE9 transgenic (APP/PS1) mice were detected immuno histological analysis, real-time PCR, western blotting assay. progression was determined levels, activated neurons (MAP2+), microglia (Iba-1+). learning ability measured...
Stroke remains a leading cause of death and disability. The low-density lipoprotein cholesterol to high-density (LDL-C/HDL-C ratio) ratio has been confirmed be predictor stroke. However, few studies have assessed the prognostic impact LDL-C/HDL-C for stroke patients. We aimed investigate relationship between prognosis following in Chinese A total 3,410 patients who had experienced their first ischemic was recruited this study within 72 h onset. were followed at least 12 months. multivariate...
Inflammation resolution is regulated by specialized pro-resolving lipid mediators (SPMs) and the levels of SPMs are found decreased in Alzheimer's disease (AD) brain. We have previously that one SPMs, Maresin1 (MaR1), improved neuronal survival increase microglial phagocytosis amyloid-β 1-42 (Aβ42); however, mechanisms underlying protective mechanism remain further investigation. aim to investigate effects MaR1 on chemotaxis activation this study. Both indirect direct primary neuron...
Abstract The neuroprotective effects of ethyl pyruvate (EP) have been proved in several brain injury models, yet very little is known about its action on neonatal white matter injury. To investigate the effect EP matte damage, a stereotactic intracerebral injection lipopolysaccharide (LPS, 1 mg/kg) was performed postnatal day 5 Sprague–Dawley rat pups, and administrated intraperitoneally at dose 40 mg/kg immediately, h 12 after LPS exposure. Significantly, treatment with reduced LPS‐induced...
Background: The purpose of the present study was to investigate effects Onjisaponin B (OB) in lipopolysaccharide (LPS)-induced cognitive deficits. Methods: rats were divided into four groups: sham group, LPS group (the model group), + OB (1 mg/kg) and (2 group. treated three days before surgery thereafter continuously for 7 days. Three later, intracerebroventricularly injected with LPS. levels inflammatory cytokines capability free radical scavenging serum hippocampus determined after...
The current study explored the influences of genetic and environmental factors on mental health twins between ages 6 16. A total 41 monozygotic (MZ) 35 dizygotic were recruited. psychological attributes information children evaluated. significant correlation was found in diagnostic categories any psychiatric disorder attention deficit/hyperactivity (ADHD)/hyperkinesis based Strengths Difficulties Questionnaire scale MZ twins. Furthermore, fathers' authoritarian parenting style positively...
Non-dipper blood pressure has been shown to affect cardiovascular outcomes and cognitive function in patients with hypertension. Although some studies have explored the influencing factors of non-dipper pressure, there is still relatively little research on constructing a prediction model. This study aimed develop validate simple practical nomogram model explore relevant elements that could dipper relationship A convenient sampling method was used select 356 inpatients hypertension who...
The objective of this paper was to study the effects PYR-ARG-PRO-ARG-LEU-SER-HIS-YSGLY-PRO-MET-PRO-PHE-OH (APELIN-13) on expression inflammatory factors interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) in rats with experimental autoimmune neuritis (EAN). A total 30 were divided into a control group, an EAN APELIN-13 group. Enzyme-linked immunosorbent assay (ELISA) used detect levels IL-6, TNF-α, IFN-γ rat plasma. Real-time quantitative Polymerase Chain Reaction...
Objective To systematically review the efficacy of hydromorphone hydrochloride injection for treatment chronic pain. Methods Web Science Proceedings and PubMed were searched clinical trials involving pain, with no language or time limit.Evaluation indexes included visual analogue scale (VAS) score rate pain control relief.The studies screened independently, data extracted by two researchers.Meta-analysis was conducted using Stata 10 software. Results Eleven 452 patients in our...
Objective To investigate clinical features and the early recurrence factors of watershed infarction(WSI).Methods Two hundred eighty-three patients with acute anterior circulation vascular infraction confirmed by CT or MRI were collected in Heilongjiang Province Hospital from January 2010 to December 2012.Patients' information including gender,sex,risk for stroke stenosis was colleced.Patients divided into lacunar infarction group (n =83),large group(n =60) WSI =140).All followed up 6 months...