A5103045094- Hereditary Neurological Disorders
- Plant Gene Expression Analysis
- Neurological diseases and metabolism
- Genetic Neurodegenerative Diseases
- Obstructive Sleep Apnea Research
- Amyotrophic Lateral Sclerosis Research
- Sphingolipid Metabolism and Signaling
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Calcium signaling and nucleotide metabolism
- Signaling Pathways in Disease
- Lysosomal Storage Disorders Research
- Immune cells in cancer
- Glycosylation and Glycoproteins Research
- Traditional Chinese Medicine Analysis
- Adenosine and Purinergic Signaling
- Cellular transport and secretion
- melanin and skin pigmentation
- Phagocytosis and Immune Regulation
- Peripheral Neuropathies and Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacological Receptor Mechanisms and Effects
- Phytochemical compounds biological activities
- Voice and Speech Disorders
- RNA and protein synthesis mechanisms
University of Science and Technology of China
2025
Chinese Academy of Sciences
2025
Peking University
2006-2025
Changchun Institute of Applied Chemistry
2025
Third Xiangya Hospital
2019-2024
Central South University
2019-2024
Chinese University of Hong Kong
2010-2023
Guangdong Provincial Hospital of Traditional Chinese Medicine
2021
Renmin Hospital of Wuhan University
2017-2018
Wuhan University
2017-2018
The R2R3-MYB transcription factor is one of the largest gene families in plants and involved regulation plant development, hormone signal transduction, biotic abiotic stresses. Tobacco most important model plants. Therefore, it will be great significance to investigate family their expression patterns under stress senescence tobacco.A total 174 genes were identified from tobacco (Nicotiana tabacum L.) genome divided into 24 subgroups based on phylogenetic analysis. Gene structure...
The impact of chirality on immune response has attracted great interest in cancer vaccine research recently. However, the study chiral synthetic polypeptide hydrogels as vaccines well biomaterials themselves for antitumor immunotherapy rarely been reported. Here, we show key role residue immunity and local microenvironment regulation. Compared to poly(γ-ethyl-L-glutamate)-based (L-Gel), poly(γ-ethyl-D-glutamate)-based (D-Gel) induces enhanced level cell infiltration. D-Gel causes higher...
In human pancreatic adenocarcinoma, nuclear factor-kappa-B (NF-kappaB) transcription factor is constitutively activated that contributes to the resistance of tumour cells induced apoptosis. our earlier studies, we have shown brucein D (BD) mediated apoptosis through activation p38-mitogen-activated protein kinase (MAPK) signalling pathway in cancer cells. This study investigated function reactive oxygen species (ROS) BD-mediated p38-MAPK and NF-kappaB pathways PANC-1 cells.Glutathione...
The purpose was to provide an overview of genotype and phenotype distribution in a cohort patients with Charcot-Marie-Tooth disease (CMT) related disorders from central south China.In all, 435 were enrolled detailed clinical data collected. Multiplex ligation-dependent probe amplification for PMP22 duplication/deletion CMT multi-gene panel sequencing performed. Whole exome further applied the remaining who failed achieve molecular diagnosis.Among patients, 216 had CMT1, 14 hereditary...
Our previous studies showed that the alcohol extract of fruit Brucea javanica (Fructus Bruceae) possessed significant cytotoxicity in pancreatic adenocarcinoma cell lines. A bioassay-guided fractionation and purification resulted isolation characterization seven quassinoids including brusatol, bruceine D, H, yadanzioside A, G, javanicoside C bruceantinoside A. Among them, brusatol exhibited most potent vitro antipancreatic cancer action, with IC(50) values 0.36 µm 0.10 on PANC-1 SW1990...
Abstract Distal hereditary motor neuropathy (dHMN) is a clinically and genetically heterogeneous group of inherited neuropathies characterized by distal limb muscle wasting weakness with no or minimal sensory abnormalities. To investigate the clinical genetic features dHMN caused WARS mutations in mainland China, we performed Sanger sequencing coding untranslated region (UTR) regions 160 unresolved Charcot‐Marie‐Tooth (CMT) index patients. We detected novel heterozygous variant c.941A>G...
Growing evidence proves that amino acid restriction can reverse obesity by reducing adipose tissue mass. Amino acids are not only the building blocks of proteins but also serve as signaling molecules in multiple biological pathways. The study adipocytes' response to level changes is crucial. It has been reported a low concentration lysine suppresses lipid accumulation and transcription several adipogenic genes 3T3-L1 preadipocytes. However, detailed lysine-deprivation-induced cellular...
Background and Objectives: Distal hereditary motor neuropathy (dHMN) is a clinically genetically heterogeneous group of inherited neuropathies. The objectives this study were to report the clinical genetic features dHMN patients in Chinese cohort. Aims Methods: We performed assessments whole-exome sequencing 24 families from Mainland China. conducted retrospective analysis data investigated frequency with confirmed mutation. Results: Two novel heterozygous mutations GARS , c.373G>C...
Charcot-Marie-Tooth (CMT) disease is a clinically and genetically heterogeneous group of inherited peripheral neuropathies. The wide phenotypic variability may not be completely explained by single mutation.To explore the existence concomitant variants in CMT, we enrolled 189 patients performed molecular diagnosis application next-generation sequencing combined with multiplex ligation-dependent probe amplification. We conducted retrospective analysis harboring coinherited different...
Abstract Background and Aims Biallelic variants in the sorbitol dehydrogenase ( SORD ) gene have been identified as genetic cause of autosomal recessive (AR) peripheral neuropathy (PN) manifesting Charcot–Marie–Tooth disease type 2 (CMT2) or distal hereditary motor (dHMN). We aim to observe clinical spectrum a cohort patients with SORD‐related PN (SORD‐PN). Methods A total 107 AR sporadic CMT2/dHMN underwent molecular diagnosis by whole‐exome sequencing subsequent Sanger validation....
Abstract Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neuromuscular disease. Recently, several gain-of-function mutations in SPTLC1 were associated with juvenile ALS. encodes for subunit of the serine-palmitoyltransferase (SPT) - rate-limiting enzyme de novo synthesis sphingolipids (SL). Here we identified novel SPTLC1p . L38R mutation young Chinese girl signature The patient presented muscular weakness atrophy, tongue tremor fasciculation, breathing problems positive...
Objectives/Hypothesis To evaluate changes in pharyngeal wall floppiness (PWF) between patients with obstructive sleep apnea‐hypopnea syndrome induced by non–upper‐airway structural factors and normal subjects, as well the clinical significance using acoustic pharyngealmetry technology. Study Design Cohort study. Methods The apnea (OSA) group (n = 102) control 50) were identified Eccovision Acoustic Pharyngometer measuring instrument. volume of cavity sitting supine positions during...
Objective: Acoustic pharyngealmetry technology is utilized to evaluate the change and clinical significance of obstructive sleep apnea-hypopnea syndrome (OSAHS) patients caused by non-upper airway structural factor normal individuals' PWF(pharyngeal wall floppiness). Methods: instrument Ecconvision was examine 102 OSAHS 50 individuals, separately recorded their volume pharyngeal cavity in sit or supine position, calculated PWF SPSS 12.0 tware used analyze data. Results: 0.14±0.09 position...